The nature of sites of general anaesthetic action

British Journal of Anaesthesia

Volumn 89, Issue 1, 2002, Pages 17-31

  Miller, K W ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anaesthesia, binding sites; Anaesthesia, general

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; AMOBARBITAL; ANESTHETIC AGENT; CHOLINERGIC RECEPTOR; GLYCINE RECEPTOR; HALOTHANE; ION CHANNEL; ISOFLURANE; MEMBRANE PROTEIN; PROPOFOL; SOLVENT;

ALPHA HELIX; ANESTHESIA MECHANISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CRYSTALLIZATION; CRYSTALLOGRAPHY; DRUG CONFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG TARGETING; GENERAL ANESTHESIA; IN VIVO STUDY; KINETICS; MEDICAL RESEARCH; PHOTOAFFINITY LABELING; POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0036069233     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aef167     Document Type: Article

References (74)

1. Geometric isomers of a photoactivatible general anaesthetic delineate a binding site on adenylate kinase
2. Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel
3. Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions
4. Binding of the general anaesthetics propofol and halothane to human serum albumin. High resolution crystal structures
5. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
6. New photolabeling and crosslinking methods
7. Breaking the Meyer-Overton rule: Predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anaesthetics
8. Allosteric receptors after 30 years
9. A binding site for the volatile anaesthetic halothane within the nicotnic acetylcholne receptor identified by photoaffinity labeling
10. The inhalation convulsants: A pharmacodynamic approach
11. 125l]azido-cholesterol
12. Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors
13. Behavioral effects of volatile anaesthetics in Caenorhabditis elegans
14. Effects of general anaesthetics on the bacterial luciferase enzyme from Vibrio harveyi: An anaesthetic target site with differential sensitivity
15. Barbiturate action is dependent on the conformational state of the acetylcholine receptor
16. The effects of general anaesthetics on ligand-gated on channels
17. Barbiturates bind to an allosteric regulatory site on nicotinic acetylcholine receptor-rich membranes
18. 3H]Ro 15-4513
19. Amino acid resolution of halothane binding sites in serum albumin
20. An inhalational anaesthetic binding domain in the nicotinic acetylcholine receptor
21. Promiscuous ligands and attractive cavities
22. Halogenated diazirines as photolabel mimics of the inhaled haloalkane anaesthetics
23. Hypothesis: Inhaled anaesthetics produce immobility and amnesia by different mechanisms at different sites
24. Access of ligands to cavities within the core of a protein is rapid
25. A discrete site for general anaesthetics on a postsynaptic receptor
26. Nonanaesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models
27. How does xenon produce anaesthesia?
28. Structural basis for the inhibition of firefly luciferase by a general anaesthetic
29. Do general anaesthetics act by competitive binding to specific receptors?
30. Mapping the conformational wave of acetylcholine receptor channel gating
31. Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment
32. Structural biology of key nervous system proteins
33. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photo-activable activable general anaesthetic
34. Evidence for a common binding cavity for three general anaesthetics within the GABAA receptor
35. Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue
36. Propofol and other intravenous anaesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
37. Modeling protein-small molecule interactions: Structure and thermodynamics of noble gases binding in a cavity in mutant phage T4 lysozyme L99A
38. Zur Theorie der Alkoholnarkose. Der Einfluss wechselnder Temperatur auf Wirkungsstärke und Theilungscoefficient der Narcotica
39. General anaesthetics and bacterial luminescence. II. The effect of diethyl ether on the in vitro light emission of Vibrio fischeri
40. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors
41. The nature of the site of general anaesthesia
42. Approaches to proving there are general anaesthetic sites on ligand gated ion channels
43. Physico-chemical approaches to the mode of action of general anaesthetics
44. Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme
45. Some physical mechanisms of narcosis
46. Barbiturate enhancement of γ-aminobutyric acid receptor binding and function as a mechanism of anaesthesia
47. Studies of narcosis and a contribution to general pharmacology
48. Barbiturates and the brain
49. A and glycine receptors expressed in Xenopus laevis oocytes: A comparative study
50. Exploring hydrophobic sites in proteins with xenon or krypton
51. Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anaesthetic
52. Size versus polarizability in protein-ligand interactions: Binding of noble gases within engineered cavities in phage T4 lysozyme
53. Nonhalogenated alkane anaesthetics fail to potentiate agonist actions on two ligand-gated ion channels
54. The cholesterol dependence of activation and fast desensitization of the nicotinic acetylcholine receptor
55. Actions of pentobarbital enantiomers on nicotinic cholinergic receptors
56. Halothane binds in the adenine-specific niche of crystalline adenylate kinase
57. Binding of cyclopropane to sperm whale myoglobin
58. Binding of xenon to sperm whale myoglobin
59. Model organisms: New insights into ion channel and transporter function. Stomatin homologues interact in Caenorhabditis elegans
60. A receptors
61. General anaesthetic binding to gramicidin A: The structural requirements
62. Cavities in proteins: Structure of a metmyoglobin-xenon complex solved to 1.9 A
63. Protein-ligand dynamics: A picosecond simulation of a myoglobin-xenon complex
64. Molecular modelling of specific and non-specific anaesthetic interactions
65. The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission
66. Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases
67. Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo
68. Cycloalkanemethanols discriminate between volume- and length-dependent loss of activity of alkanols at the Torpedo nicotinic acetylcholine receptor
69. Channel inhibition by alkanols occurs at a binding site on the nicotinic acetylcholine receptor
70. Nucleoside monophosphate kinases: Structure, mechanism, and substrate specificity
71. The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch
72. Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anaesthetic potency