(Z,Z)-2,7-Bis(4-amidinobenzylidene)cyclo-heptan-1-one: Identification of a highly active inhibitor of blood coagulation factor Xa [1]

Journal of Medicinal Chemistry

Volumn 41, Issue 19, 1998, Pages 3551-3556

  Shaw, K J ^a   Guilford, W J ^a   Dallas, J L ^a   Koovakkaat, S K ^a   McCarrick, M A ^a   Liang, A ^a   Light, D R ^a   Morrissey, M M ^a  

^a Discovery Research Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,7 BIS(4 AMIDINOBENZYLIDENE)CYCLOHEPTAN 1 ONE; AMIDINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

BLOOD CLOTTING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; INHIBITION KINETICS; LETTER; NONHUMAN;

AMIDINES; ANIMALS; BENZYLIDENE COMPOUNDS; BINDING SITES; CATTLE; FACTOR XA; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOTOCHEMISTRY; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; THROMBIN; TRYPSIN INHIBITORS;

EID: 0032505133     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980281+     Document Type: Letter

References (34)