Discovery of N-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-3,5- difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy] pyridin-4-yl]- n-methylglycine (ZK-807834): A potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa [2]

Journal of Medicinal Chemistry

Volumn 41, Issue 19, 1998, Pages 3557-3562

  Phillips, G B ^a   Buckman, B O ^a   Davey, D D ^a   Eagen, K A ^a   Guilford, W J ^a   Hinchman, J ^a   Ho, E ^a   Koovakkat, S ^a   Liang, A ^a   Light, D R ^a   Mohan, R ^a   Ng, H P ^a   Post, J M ^a   Shaw, K J ^a   Smith, D ^a   Subramanyam, B ^a   Sullivan, M E ^a   Trinh, L ^a   Vergona, R ^a   Walters, J ^a   White, K ^a   Whitlow, M ^a   Wu, S ^a   Xu, W ^a   Morrissey, M M ^a   more..

^a Discovery Research Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; N [2 [5 [AMINO(IMINO)METHYL] 2 HYDROXYPHENOXY] 3,5 DIFLUORO 6 [3 (4,5 DIHYDRO 1 METHYL 1H IMIDAZOL 2 YL)PHENOXY]PYRIDIN 4 YL] N METHYLGLYCINE; PROTHROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; BABOON; BLOOD CLOTTING TIME; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; LETTER; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PROTHROMBIN TIME;

ADMINISTRATION, ORAL; AMIDINES; ANIMALS; ANTICOAGULANTS; BENZYLIDENE COMPOUNDS; BINDING SITES; BIOLOGICAL AVAILABILITY; CATTLE; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG EVALUATION, PRECLINICAL; FACTOR XA; HUMANS; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PAPIO; PYRIDINES; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN INHIBITORS;

EID: 0032505156     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980280h     Document Type: Letter

References (23)