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Volumn 10, Issue 8, 2002, Pages 2597-2610

Design, synthesis and biological activity of YM-60828 derivatives: Potent and orally-bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates

(17) Hirayama, Fukushi a Koshio, Hiroyuki a Ishihara, Tsukasa a Watanuki, Susumu a Hachiya, Shunichiro a Kaizawa, Hiroyuki a Kuramochi, Takahiro a Katayama, Naoko a Kurihara, Hiroyuki a Taniuchi, Yuta a Sato, Kazuo a Sakai Moritani, Yumiko a Kaku, Seiji a Kawasaki, Tomihisa a Matsumoto, Yuzo a Sakamoto, Shuichi a Tsukamoto, Shin ichi a

a ASTELLAS PHARMA INC (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL] N [(7 AMIDINO 2 NAPHTHYL)METHYL]SULFAMOYL]ACETIC ACID; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING INHIBITOR; N [2 (5 AMIDINO 2 HYDROXYPHENOXY) 3,5 DIFLUORO 6 [3 (1 METHYL 1H 2 IMIDAZOLIN 2 YL)PHENOXY] 4 PYRIDINYL] N METHYLGLYCINE; NAPHTHALENE DERIVATIVE; NAPHTHOL DERIVATIVE; UNCLASSIFIED DRUG; ANILIDE; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; PIPERIDINE DERIVATIVE; SERINE PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IC 50; MALE; MOUSE; NONHUMAN; PROTHROMBIN TIME; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BIOAVAILABILITY; CEBIDAE; DRUG ANTAGONISM; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

SAIMIRI; SCIURIDAE;

ADMINISTRATION, ORAL; ANILIDES; ANIMALS; ANTICOAGULANTS; BIOLOGICAL AVAILABILITY; DRUG DESIGN; FACTOR XA; FEMALE; MALE; MICE; NAPHTHALENES; PIPERIDINES; PROTHROMBIN TIME; SAIMIRI; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036285561 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(02)00106-2 Document Type: Article

Times cited : (25)

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