RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 5, 2001, Pages 693-696

  Collis, Alan J ^a   Foster, Martyn L ^a   Halley, Frank ^a   Maslen, Christopher ^a   McLay, Iain M ^a   Page, Kenneth M ^a   Redford, E J ^a   Souness, John E ^a   Wilsher, Nicola E ^a  

^a Aventis Pharma Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (5 METHYL 5 MORPHOLINOCARBONYL 1,3 DIOXAN 2 YL) 5 (4 PYRIDINYL)IMIDAZOLE; AMINOPYRIMIDINE DERIVATIVE; CYTOCHROME P450; CYTOKINE; PYRIMIDINE DERIVATIVE; RPR 203494; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANKLE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; EDEMA; ENZYME INHIBITION; MONOCYTE; NONHUMAN; RAT; RHEUMATOID ARTHRITIS;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIMIDINES; RANDOM ALLOCATION; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035848384     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00034-8     Document Type: Article

References (9)