Synthesis of RHPS4 via an anionic ring closing cascade

Tetrahedron Letters

Volumn 49, Issue 15, 2008, Pages 2351-2354

  Kristensen, Jesper Langgaard ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antitumour agents; Cyclizations; Fused ring systems; Nucleophilic aromatic substitutions; Ring closure

Indexed keywords

TELOMERASE ANTAGONIST RHPS4; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DIMERIZATION; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; METHYLATION; RING CLOSING METATHESIS;

EID: 40649123276     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.02.074     Document Type: Article

References (19)

1. (a) T.R. Cech Angew. Chem., Int. Ed. 39 2000 34
2. (b) L.R. Kelland Eur. J. Cancer 41 2005 971
3. R.A. Heald C. Modi J.C. Cookson I. Hutchinson C.A. Laughton S.M. Gowan L.R. Kelland M.F. Stevens J. Med. Chem. 45 2002 590
4. (a) E. Gavathiotis R.A. Heald M.F.G. Stevens M.S. Searle Angew. Chem., Int. Ed. 40 2001 4749
5. (b) S.M. Gowan R. Heald M.F.G. Stevens L.R. Kelland Mol. Pharm. 60 2001 981
6. (c) E. Gavathiotis R.A. Heald M.F.G. Stevens M.S. Searle J. Mol. Biol. 334 2003 25
7. J.C. Cookson R.A. Heald M.F.G. Stevens J. Med. Chem. 48 2005 7198
8. J. Oszczapowicz J. Jaroszewska-Manaj E. Ciszak M. Gdaniec Tetrahedron 44 1988 6645
9. D.J. Hagan E. Giménez-Arnau C.H. Schwalbe M.F. Stevens J. Chem. Soc., Perkin Trans. 1 1997 2739
10. (a) R.A. Heald C. Modi J.C. Cookson I. Hutchinson C.A. Laughton S.M. Gowan L.R. Kelland M.F. Stevens J. Med. Chem. 45 2002 590
11. (b) I. Hutchinson M.F.G. Stevens Org. Biomol. Chem. 5 2007 114
12. J.L. Kristensen P. Vedso M. Begtrup J. Org. Chem. 68 2003 4091
13. (a) N. Miyaura T. Yanagi A. Suzuki Synth. Commun. 11 1981 513
14. (b) N. Miyaura A. Suzuki Chem. Rev. 95 1995 2457
15. J.H. Gorvin J. Chem. Soc., Perkin Trans. 1 1988 1331
16. D.J. Blears S.S. Danyluk T. Schaeffe J. Chem. Phys. 47 1967 5037
17. S.C. Goodacre L.J. Street D.J. Hallett J.M. Crawforth S. Kelly A.P. Owens W.P. Blackaby R.T. Lewis J. Stanley A.J. Smith P. Ferris B. Sohal S.M. Cook A. Pike N. Brown K.A. Wafford G. Marshall J.L. Castro J.R. Atack J. Med. Chem. 49 2006 35
18. W.E. Parham C.K. Bradsher Acc. Chem. Res. 15 1982 300
19. K. Paek C.B. Knobler E.F. Maverick D.J. Cram J. Am. Chem. Soc. 111 1989 8662