Antitumour polycyclic acridines. Part 1. Synthesis of 7H-pyrido- and 8H-quino-[4,3,2-kl]acridines by Graebe-Ullmann thermolysis of 9-(1,2,3-triazol-1-yl)acridines: Application of differential scanning calorimetry to predict optimum cyclisation conditions

Journal of the Chemical Society - Perkin Transactions 1

Volumn , Issue 18, 1997, Pages 2739-2746

  Hagan, Damien J ^a   Giménez Arnau, Elena ^a   Schwalbe, Carl H ^b   Stevens, Malcolm F G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33748587608     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/a702299i     Document Type: Article

References (25)

1. A. Albert, The Acridines, Edward Arnold (Publishers) Ltd., London, UK, 2nd edn., 1966.
2. A. Albert, Selective Toxicity, Chapman and Hall, London, 7th edn., 1985, p. 379.
3. A. C. Mair and M. F. G. Stevens, J. Chem. Soc., Perkin Trans. 1, 1972, 161.
4. W. A. Denny, in The Search for New Anticancer Drugs, ed. M. J. Waring and B. A. J. Ponder, Kluwer Academic Publishers, Dordrecht, 1992, pp. 19-54.
5. G. J. Finlay, J.-F. Riou and B. C. Baguley, Eur. J. Cancer, Part A, 1996, 32, 708.
6. B. C. Baguley, Anti-Cancer Drug Des., 1991, 6, 1.
7. W. A. Denny and B. C. Baguley, in Molecular Aspects of Anti-cancer Drug-DNA Interaction, ed. S. Neidle and M. J. Waring, Macmillan, London, 1994, pp. 270-311.
8. S. Houlbrook, C. M. Addison, S. L. Davies, J. Carmichael, I. J. Stratford, A. L. Harris and I. D. Hickson, Br. J. Cancer, 1995, 72, 1454.
9. F. H. Drake, G. A. Hoffmann, H. F. Bartus, M. R. Mattern, S. T. Crooke and C. K. Mirabelli, Biochemistry, 1989, 28, 8154.
10. M. I. Sandri, D. Hochhauser, P. Ayton, R. C. Camplejohn, R. Whitehouse, H. Turley, K. Gatter, I. D. Hickson and A. L. Harris, Br. J. Cancer, 1996, 73, 1518.
11. L. F. Liu, Annu. Rev. Biochem., 1989, 58, 351.
12. L. A. McDonald, G. S. Eldredge, L. R. Barrows and C. M. Ireland, J. Med. Chem. 1994, 37, 3819.
13. T. F. Molinski, Chem. Rev., 1993, 93, 1825.
14. C. K. Wong, PhD Thesis, Aston University, UK, 1980.
15. G. Mitchell and C. W. Rees, J. Chem. Soc., Perkin Trans. 1, 1987, 403.
16. G. Mitchell and C. W. Rees, J. Chem. Soc., Perkin Trans. 1, 1987, 413.
17. G. A. Reynolds, J. Org. Chem., 1964, 29, 3733.
18. J. L. Ford and P. Timmis, Pharmaceutical Thermal Analysis, Ellis Horwood, 1988.
19. A. Molina, J. J. Vaquero, J. L. García-Navio and J. Alvarez-Builla, Tetrahedron Lett., 1993, 34, 2673.
20. W. A. Denny, G. J. Atwell and B. C. Baguley, J. Med. Chem., 1983, 26, 1625.
21. M. W. Schmidt, K. K. Baldridge, J. A. Boatz, J. H. Jensen, S. Koseki, M. S. Gordon, K. A. Nguyen, T. L. Windus and S. T. Elbert, QCPE Bulletin, 1990, 10, 52.
22. C. K. Johnson, ORTEP, Report ORNL-5136, Oak Ridge National Laboratory, Tennessee, USA, 1976.
23. K. Gleu and S. Nitzsche, J. Prakt. Chem., 1939, 153, 200.
24. P. Main, G. Germain and M. M. Woolfson, MULTAN84, A System of Computer Programs for the Automatic Solution of Crystal Structures from X-ray Diffraction Data, Universities of York, England, and Louvain, Belgium, 1984.
25. G. M. Sheldrick, SHELXL93, Program for the Refinement of Crystal Structures, University of Göttingen, Germany, 1993.