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Volumn 7, Issue 4, 2008, Pages 633-640

Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms

Author keywords

Checkpoint; DNA damage response; Expansion; Replicational coupling; Trinucleotide repeat

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CSM3 PROTEIN; DDC1 PROTEIN; DDC2 PROTEIN; DNA POLYMERASE; HELICASE; MEC1 PROTEIN; MEC3 PROTEIN; MRC1 PROTEIN; PROTEIN; PROTEIN DERIVATIVE; PROTEIN RAD9; RAD17 PROTEIN; RAD24 PROTEIN; SINGLE STRANDED DNA; TOF1 PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CSM3P PROTEIN, S CEREVISIAE; DNA BINDING PROTEIN; MRC1 PROTEIN, S CEREVISIAE; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEIN; TOF1 PROTEIN, S CEREVISIAE;

EID: 40649114958     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.01.009     Document Type: Article
Times cited : (38)

References (41)
  • 1
  • 2
    • 34250878426 scopus 로고    scopus 로고
    • Expandable DNA repeats and human disease
    • S.M. Mirkin Expandable DNA repeats and human disease Nature 447 2007 932 940
    • (2007) Nature , vol.447 , pp. 932-940
    • Mirkin, S.M.1
  • 3
    • 0026767610 scopus 로고
    • Dynamic mutations: a new class of mutations causing human disease
    • R.I. Richards G.R. Sutherland Dynamic mutations: a new class of mutations causing human disease Cell 70 1992 709 712
    • (1992) Cell , vol.70 , pp. 709-712
    • Richards, R.I.1    Sutherland, G.R.2
  • 4
    • 0029053371 scopus 로고
    • Trinucleotide repeats that expand in human disease form hairpin structure in vitro
    • A.M. Gacy G. Goellner N. Juranic S. Macura C.T. McMurray Trinucleotide repeats that expand in human disease form hairpin structure in vitro Cell 81 1995 533 540
    • (1995) Cell , vol.81 , pp. 533-540
    • Gacy, A.M.1    Goellner, G.2    Juranic, N.3    Macura, S.4    McMurray, C.T.5
  • 5
    • 0029883805 scopus 로고    scopus 로고
    • Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci
    • C.E. Pearson R.R. Sinden Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci Biochemistry 35 1996 5041 5053
    • (1996) Biochemistry , vol.35 , pp. 5041-5053
    • Pearson, C.E.1    Sinden, R.R.2
  • 6
    • 0032570797 scopus 로고    scopus 로고
    • Analysis of strand slippage in DNA polymerase expansions of CAG/CTG triplet repeats associated with neurodegenerative diseases
    • J. Petruska M.J. Hartenstine M.F. Goodman Analysis of strand slippage in DNA polymerase expansions of CAG/CTG triplet repeats associated with neurodegenerative diseases J. Biol. Chem. 273 1998 5204 5210
    • (1998) J. Biol. Chem. , vol.273 , pp. 5204-5210
    • Petruska, J.1    Hartenstine, M.J.2    Goodman, M.F.3
  • 7
    • 0030725454 scopus 로고    scopus 로고
    • Trinucleotide repeats affect DNA replication in vivo
    • G.M. Samadashwily G. Raca S.M. Mirkin Trinucleotide repeats affect DNA replication in vivo Nature Genet. 17 1997 298 304
    • (1997) Nature Genet. , vol.17 , pp. 298-304
    • Samadashwily, G.M.1    Raca, G.2    Mirkin, S.M.3
  • 9
    • 0029035379 scopus 로고
    • Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli
    • S. Kang A. Jaworski K. Ohshima R.D. Wells Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli Nat. Genet. 10 1995 213 218
    • (1995) Nat. Genet. , vol.10 , pp. 213-218
    • Kang, S.1    Jaworski, A.2    Ohshima, K.3    Wells, R.D.4
  • 10
    • 0028873248 scopus 로고
    • Somatic mosaicism, germline expansions, germline reversions and intergenerational reductions in myotonic dystrophy males: small pool PCR analyses
    • D.G. Monckton L.J. Wong T. Ashizawa C.T. Caskey Somatic mosaicism, germline expansions, germline reversions and intergenerational reductions in myotonic dystrophy males: small pool PCR analyses Hum. Mol. Genet. 4 1995 1 8
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1-8
    • Monckton, D.G.1    Wong, L.J.2    Ashizawa, T.3    Caskey, C.T.4
  • 11
    • 0034639711 scopus 로고    scopus 로고
    • Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability
    • M.T. Fortune C. Vassilopoulos M.I. Coolbaugh M.J. Siciliano D.G. Monckton Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability Hum. Mol. Genet. 9 2000 439 445
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 439-445
    • Fortune, M.T.1    Vassilopoulos, C.2    Coolbaugh, M.I.3    Siciliano, M.J.4    Monckton, D.G.5
  • 12
    • 0034194141 scopus 로고    scopus 로고
    • Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability
    • H. Seznec A.-S. Lia-Baldini C. Duros C. Fouquet C. Lacroix H. Hofmann-Radvanyi C. Junien G. Gourdon Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability Hum. Mol. Genet. 9 2000 1185 1194
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1185-1194
    • Seznec, H.1    Lia-Baldini, A.-S.2    Duros, C.3    Fouquet, C.4    Lacroix, C.5    Hofmann-Radvanyi, H.6    Junien, C.7    Gourdon, G.8
  • 13
    • 0037081784 scopus 로고    scopus 로고
    • Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins
    • W.J.A.A. van den Broek M.R. Nelen D.G. Wansink M.M. Coerwinkel H. te Riele P.J.T.A. Groenen B. Wieringa Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins Hum. Mol. Genet. 11 2002 191 198
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 191-198
    • van den Broek, W.J.A.A.1    Nelen, M.R.2    Wansink, D.G.3    Coerwinkel, M.M.4    te Riele, H.5    Groenen, P.J.T.A.6    Wieringa, B.7
  • 14
    • 0031965224 scopus 로고    scopus 로고
    • Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation
    • J.K. Schweitzer D.M. Livingston Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation Hum. Mol. Genet. 7 1998 69 74
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 69-74
    • Schweitzer, J.K.1    Livingston, D.M.2
  • 15
    • 0032488872 scopus 로고    scopus 로고
    • Expansion and length-dependent fragility of CTG repeats in yeast
    • C.H. Freudenreich S.M. Kantrow V.A. Zakian Expansion and length-dependent fragility of CTG repeats in yeast Science 279 1998 853 856
    • (1998) Science , vol.279 , pp. 853-856
    • Freudenreich, C.H.1    Kantrow, S.M.2    Zakian, V.A.3
  • 17
    • 4344636050 scopus 로고    scopus 로고
    • Yeast Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats
    • S. Bhattacharyya R.S. Lahue Yeast Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats Mol. Cell. Biol. 24 2004 7324 7330
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7324-7330
    • Bhattacharyya, S.1    Lahue, R.S.2
  • 18
    • 33845785225 scopus 로고    scopus 로고
    • Postreplication repair inhibits CAG·CTG repeat expansions in Saccharomyces cerevisiae
    • D.L. Daee T. Mertz R.S. Lahue Postreplication repair inhibits CAG·CTG repeat expansions in Saccharomyces cerevisiae Mol. Cell. Biol. 27 2007 102 110
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 102-110
    • Daee, D.L.1    Mertz, T.2    Lahue, R.S.3
  • 20
    • 13444253858 scopus 로고    scopus 로고
    • Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases
    • C.H. Freudenreich M. Lahiri Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases Cell Cycle 3 2004 1370 1374
    • (2004) Cell Cycle , vol.3 , pp. 1370-1374
    • Freudenreich, C.H.1    Lahiri, M.2
  • 22
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • L. Zou D. Liu S.J. Elledge Replication protein A-mediated recruitment and activation of Rad17 complexes Proc. Natl. Acad. Sci. U.S.A. 100 2003 13827 13832
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 23
    • 33845607102 scopus 로고    scopus 로고
    • The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
    • J. Majka A. Niedziela-Majka P.M. Burgers The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint Mol. Cell 24 2006 891 901
    • (2006) Mol. Cell , vol.24 , pp. 891-901
    • Majka, J.1    Niedziela-Majka, A.2    Burgers, P.M.3
  • 24
    • 33746816108 scopus 로고    scopus 로고
    • The Rad53 signal transduction pathway: replication fork stabilization, DNA repair, and adaptation
    • D. Branzei M. Foiani The Rad53 signal transduction pathway: replication fork stabilization, DNA repair, and adaptation Exp. Cell Res. 312 2006 2654 2659
    • (2006) Exp. Cell Res. , vol.312 , pp. 2654-2659
    • Branzei, D.1    Foiani, M.2
  • 25
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • J.M. Sogo M. Lopes M. Foiani Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects Science 297 2002 599 602
    • (2002) Science , vol.297 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 26
    • 0344413642 scopus 로고    scopus 로고
    • The S-phase checkpoint and its regulation in Saccharomyces cerevisiae
    • M.P. Longhese M. Clerici G. Lucchini The S-phase checkpoint and its regulation in Saccharomyces cerevisiae Mutat. Res. 532 2003 41 58
    • (2003) Mutat. Res. , vol.532 , pp. 41-58
    • Longhese, M.P.1    Clerici, M.2    Lucchini, G.3
  • 27
    • 24044463869 scopus 로고    scopus 로고
    • Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae
    • S.J. Szyjka C.J. Viggiani O.M. Aparicio Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae Mol. Cell 19 2005 691 697
    • (2005) Mol. Cell , vol.19 , pp. 691-697
    • Szyjka, S.J.1    Viggiani, C.J.2    Aparicio, O.M.3
  • 29
    • 34249935010 scopus 로고    scopus 로고
    • Maintenance of fork integrity at damaged DNA and natural pause sites
    • H. Tourrière P. Pasero Maintenance of fork integrity at damaged DNA and natural pause sites DNA Repair 6 2007 900 913
    • (2007) DNA Repair , vol.6 , pp. 900-913
    • Tourrière, H.1    Pasero, P.2
  • 33
    • 0026769505 scopus 로고
    • Instability of simple sequence DNA in Saccharomyces cerevisiae
    • S.T. Henderson T.D. Petes Instability of simple sequence DNA in Saccharomyces cerevisiae Mol. Cell. Biol. 12 1992 2749 2757
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2749-2757
    • Henderson, S.T.1    Petes, T.D.2
  • 34
    • 0038506000 scopus 로고    scopus 로고
    • Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
    • A.J. Osborn S.J. Elledge Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53 Genes Dev. 17 2003 1755 1767
    • (2003) Genes Dev. , vol.17 , pp. 1755-1767
    • Osborn, A.J.1    Elledge, S.J.2
  • 35
    • 0001313535 scopus 로고
    • The distribution of the number of mutants in bacterial populations
    • D.E. Lea C.A. Coulson The distribution of the number of mutants in bacterial populations J. Genet. 49 1948 264 284
    • (1948) J. Genet. , vol.49 , pp. 264-284
    • Lea, D.E.1    Coulson, C.A.2
  • 36
    • 0032514711 scopus 로고    scopus 로고
    • Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae
    • J.J. Miret L. Pessoa-Brandao R.S. Lahue Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae Proc. Natl. Acad. Sci. U.S.A. 95 1998 12438 12443
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 12438-12443
    • Miret, J.J.1    Pessoa-Brandao, L.2    Lahue, R.S.3
  • 37
    • 0028215472 scopus 로고
    • Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae
    • N. Burns B. Grimwade P.B. Ross-Macdonald E.-Y. Choi K. Finberg G.S. Roeder M. Snyder Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae Genes Dev. 8 1994 1087 1105
    • (1994) Genes Dev. , vol.8 , pp. 1087-1105
    • Burns, N.1    Grimwade, B.2    Ross-Macdonald, P.B.3    Choi, E.-Y.4    Finberg, K.5    Roeder, G.S.6    Snyder, M.7
  • 38
    • 0036811767 scopus 로고    scopus 로고
    • Identification of RTG2 as a modifier gene for CAG·CTG repeat instability in Saccharomyces cerevisiae
    • S. Bhattacharyya M.L. Rolfsmeier M.J. Dixon K. Wagoner R.S. Lahue Identification of RTG2 as a modifier gene for CAG·CTG repeat instability in Saccharomyces cerevisiae Genetics 162 2002 579 589
    • (2002) Genetics , vol.162 , pp. 579-589
    • Bhattacharyya, S.1    Rolfsmeier, M.L.2    Dixon, M.J.3    Wagoner, K.4    Lahue, R.S.5
  • 39
    • 2542560500 scopus 로고    scopus 로고
    • DNA elements important for CAG·CTG repeat thresholds in Saccharomyces cerevisiae
    • M.J. Dixon R.S. Lahue DNA elements important for CAG·CTG repeat thresholds in Saccharomyces cerevisiae Nucleic Acids Res. 32 2004 1289 1297
    • (2004) Nucleic Acids Res. , vol.32 , pp. 1289-1297
    • Dixon, M.J.1    Lahue, R.S.2
  • 40
    • 0031442653 scopus 로고    scopus 로고
    • A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
    • D.X. Tishkoff N. Filosi G.M. Gaida R.D. Kolodner A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair Cell 88 1997 253 263
    • (1997) Cell , vol.88 , pp. 253-263
    • Tishkoff, D.X.1    Filosi, N.2    Gaida, G.M.3    Kolodner, R.D.4
  • 41
    • 0030947319 scopus 로고    scopus 로고
    • Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae
    • J.J. Miret L. Pessoa-Brandao R.S. Lahue Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae Mol. Cell. Biol. 17 1997 3382 3387
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3382-3387
    • Miret, J.J.1    Pessoa-Brandao, L.2    Lahue, R.S.3


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