The human carcinoembryonic antigen (CEA) GPI anchor mediates anoikis inhibition by inactivation of the intrinsic death pathway

Oncogene

Volumn 27, Issue 11, 2008, Pages 1545-1553

  Camacho Leal, P ^a,b   Stanners, C P ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF TURIN   (Italy)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Anoikis; Caspases; CEA; Molecular mechanism

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CASPASE; CASPASE 8; CASPASE 9; CHIMERIC PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B;

ANIMAL CELL; ANOIKIS; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANOIKIS; APOPTOSIS; BLOTTING, WESTERN; CARCINOEMBRYONIC ANTIGEN; CASPASE 9; CELLS, CULTURED; CYTOCHROMES C; ENZYME ACTIVATION; GLYCOSYLPHOSPHATIDYLINOSITOLS; IN SITU NICK-END LABELING; MAP KINASE SIGNALING SYSTEM; MYOBLASTS; NEURAL CELL ADHESION MOLECULES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 40449140034     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210789     Document Type: Article

References (39)

1. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. (1989). Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334.
2. Boatright KM, Salvesen GS. (2003). Mechanisms of caspase activation. Curr Opin Cell Biol 15: 725-731.
3. Camacho-Leal P, Zhai A, Stanners CP. (2007). A co-clustering model involving α5β1 integrin for the biological effects of GPI-anchored human Carcinoembryonic Antigen (CEA). J Cell Physiol 211: 791-802.
4. Cha YJ, Kim HS, Rhim H, Kim BE, Jeong SW, Kim IK. (2001). Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction. Exp Mol Med 33: 28492.
5. Deng Y, Lin Y, Wu X. (2002). TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev 16: 33-45.
6. Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. (2004). CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells. Oncogene 23: 465-473.
7. Eidelman FJ, Fuks A, DeMarte L, Taheri M, Stanners CP. (1993). Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. J Cell Biol 123: 467-475.
8. Frisch SM. (1999). Evidence for a function of death-receptor-related, death-domain containing proteins in anoikis. Curr Biol 9: 1047-1049.
9. Frisch SM, Ruoslahti E. (1997). Integrins and anoikis. Curr Opin Cell Biol 9: 701-706.
10. Frisch SM, Screaton RA. (2001). Anoikis mechanisms. Curr Opin Cell Biol 13: 555-562.
11. Giancotti FG, Ruoslahti E. (1999). Integrin signaling. Science 285: 1028-1032.
12. Gilmore AP. (2005). Anoikis. Cell Death Differ 12(Suppl 2): 1473-1477.
13. Grossmann J. (2002). Molecular mechanisms of 'detachment-induced apoptosis - Anoikis'. Apoptosis 7: 247-260.
14. Hammarstrom S. (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 9: 67-81.
15. Ilantzis C, DeMarte L, Screaton RA, Stanners CP. (2002). Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia 4: 151-163.
16. Li H, Zhu H, Xu CJ, Yuan J. (1998). Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501.
17. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. (1998). Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490.
18. Marconi A, Atzei P, Panza C, Fila C, Tiberio R, Truzzi F et al. (2004). FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes. J Cell Sci 117: 5815-5823.
19. Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA. (2005). Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. J Biol Chem 280: 26630-26639.
20. Nollau P, Scheller H, Kona-Horstmann M, Rohde S, Hagenmuller F, Wagener C et al. (1997). Expression of CD66a (human C-CAM) and other members of the carcino-embryonic antigen gene family of adhesion molecules in human colorectal adenomas. Cancer Res 57: 2354-2357.
21. Oikawa S, Inuzuka C, Kuroki M, Matsuoka Y, Kosaki G, Nakazato H. (1989). Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun 164: 39-45.
22. Ordonez C, Screaton RA, Ilantzis C, Stanners CP. (2000). Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res 60: 3419-3424.
23. Ordonez C, Zhai A, Camacho-Leal MP, Fan M, Stanners CP. (2007). GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through activation of integrin α5β1. J Cell Physiol 210: 757-765.
24. Reddig PJ, Juliano RL. (2005). Clinging to life: cell to matrix adhesion and cell survival. Cancer Metast Rev 24: 425-439.
25. Rennebeck G, Martelli M, Kyprianou N. (2005). Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer Res 65: 11230-11235.
26. Rojas M, DeMarte L, Screaton RA, Stanners CP. (1996). Radical differences in functions of closely related members of the human carcinoembryonic antigen gene family. Cell Growth Differ 7: 655-662.
27. Rosenberg M, Nedellec P, Jothy S, Fleiszer D, Turbide C, Beauchemin N. (1993). The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues. Cancer Res 53: 4938-4945.
28. Rytomaa M, Lehmann K, Downward J. (2000). Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene 19: 4461-4468.
29. Screaton RA, DeMarte L, Draber P, Stanners CP. (2000). The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidylinositol anchor. J Cell Biol 150: 613-626.
30. Screaton RA, Penn LZ, Stanners CP. (1997). Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation. J Cell Biol 137: 939-952.
31. Soeth E, Wirth T, List HJ, Kumbhani S, Petersen A, Neumaier M et al. (2001). Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells. Clin Cancer Res 7: 2022-2030.
32. Stanners CP, Fuks A. (1998). Properties of adhesion mediated by the human CEA family. In: Stanners CP (ed). Cell Adhesion and Communication Mediated by the CEA Family: Basic and Clinical Perspectives. Harwood Academic Publishers: Amsterdam, The Netherlands, Chapter 3, pp 57-71.
33. Stupack DG, Cheresh DA. (2002). Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 115: 3729-3738.
34. Taheri M, Saragovi HU, Stanners CP. (2003). The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked. J Biol Chem 278: 14632-14639.
35. Tian B, Lessan K, Kahm J, Kleidon J, Henke C. (2002). Beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway. J Biol Chem 277: 24667-24675.
36. Tiberio R, Marconi A, Fila C, Fumelli C, Pignatti M, Krajewski S et al. (2002). Keratinocytes enriched for stem cells are protected from anoikis via an integrin signaling pathway in a Bcl-2 dependent manner. FEBS Lett 524: 139-144.
37. Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F et al. (2001). Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci 21: 9519-9528.
38. Wang P, Valentijn AJ, Gilmore AP, Streuli CH. (2003). Early events in the anoikis program occur in the absence of caspase activation. J Biol Chem 278: 19917-19925.
39. Yaffe D. (1968). Retention of differentiation potentialities during prolonged cultivation of myogenic cells. Proc Natl Acad Sci USA 61: 477-483.