Optimization of the MHC class I peptide cargo is dependent on tapasin

Immunity

Volumn 16, Issue 4, 2002, Pages 509-520

  Williams, Anthony P ^a,b   Peh, Chen Au ^a   Purcell, Anthony W ^c   McCluskey, James ^c   Elliott, Tim ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; TAPASIN;

ALLELE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA POLYMORPHISM; ENDOPLASMIC RETICULUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN ASSEMBLY;

EID: 0036230677     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00304-7     Document Type: Article

References (41)

1. Dendritic cells and the control of immunity
2. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex
3. Cutting edge: Adenovirus E19 has two mechanisms for affecting class I MHC expression
4. Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules
5. MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum
6. Intracellular surveillance: Controlling the assembly of MHC class I-peptide complexes
7. The nature of the MHC class I peptide loading complex
8. Thermodynamic stability of HLA-B*2705. Peptide complexes. Effect of peptide and major histocompatibility complex protein mutations
9. HLA-DM induces CLIP dissociation from MHC class II dimers and facilitates peptide loading
10. Identification of the peptide binding motif for HLA-B44, one of the most common HLA-B alleles in the Caucasian population
11. How does TAP associate with MHC class I molecules?
12. Peptide-induced conformational change of the class I heavy chain
13. Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule
14. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
15. A comparison of viral immune escape strategies targeting the MHC class I assembly pathway
16. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
17. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin
18. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
19. Tapasin: An ER chaperone that controls MHC class I assembly with peptide
20. Dependence of peptide binding by MHC class I molecules on their interaction with TAP
21. Impaired assembly yet normal trafficking of MHC class I molecules in tapasin mutant mice
22. Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line
23. Herpes simplex virus turns off the TAP to evade host immunity
24. Editing of the HLA-DR-peptide repertoire by HLA-DM
25. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line 220
26. Evidence for successive peptide binding and quality control stages during MHC class I assembly
27. Tapasin is required for efficient peptide binding to transporter associated with antigen processing
28. Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide
29. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing
30. Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction
31. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes
32. HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading
33. Quantitative and qualitative influences of tapasin on the class I peptide repertoire
34. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: Coordinate up-regulation of peptide transporters and HLA-class I antigen expression
35. Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro
36. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules
37. Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: A mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes
38. Trimming of antigenic peptides in an early secretory compartment
39. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
40. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability
41. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM