메뉴 건너뛰기




Volumn 131, Issue 13, 2004, Pages 3229-3236

Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons

Author keywords

Neurodegenerative disease; Neuronal differentition; Neuronal survival; Transcription factors; Ventral tegmentum

Indexed keywords

CASPASE 3; HOMEODOMAIN PROTEIN; PROTEIN ENGRAILED; RNA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 4043165474     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01128     Document Type: Article
Times cited : (158)

References (53)
  • 1
    • 0019425974 scopus 로고
    • Development of the brain stem in the rat. V. Thymidine-radiographic study of the time of origin of neurons in the midbrain tegmentum
    • Altman, J. and Bayer, S. A. (1981). Development of the brain stem in the rat. V. Thymidine-radiographic study of the time of origin of neurons in the midbrain tegmentum. J. Comp. Neurol. 198, 677-716.
    • (1981) J. Comp. Neurol. , vol.198 , pp. 677-716
    • Altman, J.1    Bayer, S.A.2
  • 2
    • 0034926105 scopus 로고    scopus 로고
    • Does neuronal loss in Parkinson's disease involve programmed cell death?
    • Andersen, J. K. (2001). Does neuronal loss in Parkinson's disease involve programmed cell death? BioEssays 23, 640-646.
    • (2001) BioEssays , vol.23 , pp. 640-646
    • Andersen, J.K.1
  • 4
    • 0032152482 scopus 로고    scopus 로고
    • A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra
    • Blum, M. (1998). A null mutation in TGF-alpha leads to a reduction in midbrain dopaminergic neurons in the substantia nigra. Nat. Neurosci. 1, 374-377.
    • (1998) Nat. Neurosci. , vol.1 , pp. 374-377
    • Blum, M.1
  • 5
    • 0031783647 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture
    • Burke, R. E., Antonelli, M. and Sulzer, D. (1998). Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture. J. Neurochem. 71, 517-525.
    • (1998) J. Neurochem. , vol.71 , pp. 517-525
    • Burke, R.E.1    Antonelli, M.2    Sulzer, D.3
  • 6
    • 0036178992 scopus 로고    scopus 로고
    • Marked dopaminergic cell loss subsequent to developmental, intranigral expression of glial cell line-derived neurotrophic factor
    • Chun, H. S., Yoo, M. S., DeGiorgio, L. A., Volpe, B. T., Peng, D., Baker, H., Peng, C. and Son, J. H. (2002). Marked dopaminergic cell loss subsequent to developmental, intranigral expression of glial cell line-derived neurotrophic factor. Exp. Neurol. 173, 235-244.
    • (2002) Exp. Neurol. , vol.173 , pp. 235-244
    • Chun, H.S.1    Yoo, M.S.2    DeGiorgio, L.A.3    Volpe, B.T.4    Peng, D.5    Baker, H.6    Peng, C.7    Son, J.H.8
  • 7
    • 0027485950 scopus 로고
    • Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
    • Deckwerth, T. L. and Johnson, E. M., Jr (1993). Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123, 1207-1222.
    • (1993) J. Cell Biol. , vol.123 , pp. 1207-1222
    • Deckwerth, T.L.1    Johnson Jr., E.M.2
  • 8
    • 0025001744 scopus 로고
    • Early appearance of tyrosine hydroxylase immunoreactive cells in the mesencephalon of mouse embryos
    • Di Porzio, U., Zuddas, A., Cosenza-Murphy, D. B. and Barker, J. L. (1990). Early appearance of tyrosine hydroxylase immunoreactive cells in the mesencephalon of mouse embryos. Int. J. Dev. Neurosci. 8, 523-532.
    • (1990) Int. J. Dev. Neurosci. , vol.8 , pp. 523-532
    • Di Porzio, U.1    Zuddas, A.2    Cosenza-Murphy, D.B.3    Barker, J.L.4
  • 9
    • 0037037438 scopus 로고    scopus 로고
    • Medial forebrain bundle axotomy during development induces apoptosis in dopamine neurons of the substantia nigra and activation of caspases in their degenerating axons
    • El-Khodor, B. F. and Burke, R. E. (2002). Medial forebrain bundle axotomy during development induces apoptosis in dopamine neurons of the substantia nigra and activation of caspases in their degenerating axons. J. Comp. Neurol. 452, 65-79.
    • (2002) J. Comp. Neurol. , vol.452 , pp. 65-79
    • El-Khodor, B.F.1    Burke, R.E.2
  • 10
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001a). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 11
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir, S. M., Lendeckel, W. and Tuschl, T. (2001b). RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 12
    • 0035872292 scopus 로고    scopus 로고
    • Antibody to the extracellular domain of the low affinity NGF receptor stimulates p75(NGFR)-mediated apoptosis in cultured sympathetic neurons
    • Freidin, M. M. (2001). Antibody to the extracellular domain of the low affinity NGF receptor stimulates p75(NGFR)-mediated apoptosis in cultured sympathetic neurons. J. Neurosci. Res. 64, 331-340.
    • (2001) J. Neurosci. Res. , vol.64 , pp. 331-340
    • Freidin, M.M.1
  • 14
    • 0032544268 scopus 로고    scopus 로고
    • Apoptotic pathways: The roads to ruin
    • Green, D. R. (1998). Apoptotic pathways: the roads to ruin. Cell 94, 695-698.
    • (1998) Cell , vol.94 , pp. 695-698
    • Green, D.R.1
  • 15
    • 0029059790 scopus 로고
    • Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2
    • Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B. and Joyner, A. L. (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682.
    • (1995) Science , vol.269 , pp. 679-682
    • Hanks, M.1    Wurst, W.2    Anson-Cartwright, L.3    Auerbach, A.B.4    Joyner, A.L.5
  • 16
    • 0035224695 scopus 로고    scopus 로고
    • Parkinson's disease. The apoptosis hypothesis revisited
    • Hartmann, A. and Hirsch, E. C. (2001). Parkinson's disease. The apoptosis hypothesis revisited. Adv. Neurol. 86, 143-153.
    • (2001) Adv. Neurol. , vol.86 , pp. 143-153
    • Hartmann, A.1    Hirsch, E.C.2
  • 19
    • 0033955925 scopus 로고    scopus 로고
    • 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra
    • He, Y., Lee, T. and Leong, S. K. (2000). 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain Res. 858, 163-166.
    • (2000) Brain Res. , vol.858 , pp. 163-166
    • He, Y.1    Lee, T.2    Leong, S.K.3
  • 20
    • 0030045624 scopus 로고    scopus 로고
    • The roles of engrailed
    • Hidalgo, A. (1996). The roles of engrailed. Trends Genet. 12, 1-4.
    • (1996) Trends Genet. , vol.12 , pp. 1-4
    • Hidalgo, A.1
  • 22
    • 0029018424 scopus 로고
    • 6-Hydroxydopamine lesion of the rat substantia nigra: Time course and morphology of cell death
    • Jeon, B. S., Jackson-Lewis, V. and Burke, R. E. (1995). 6-Hydroxydopamine lesion of the rat substantia nigra: time course and morphology of cell death. Neurodegeneration 4, 131-137.
    • (1995) Neurodegeneration , vol.4 , pp. 131-137
    • Jeon, B.S.1    Jackson-Lewis, V.2    Burke, R.E.3
  • 23
    • 0030069671 scopus 로고    scopus 로고
    • Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development
    • Joyner, A. L. (1996). Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet. 12, 15-20.
    • (1996) Trends Genet. , vol.12 , pp. 15-20
    • Joyner, A.L.1
  • 24
    • 0028986656 scopus 로고
    • TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity
    • Krieglstein, K., Suter-Crazzolara, C., Fischer, W. H. and Unsicker, K. (1995). TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J. 14, 736-742.
    • (1995) EMBO J. , vol.14 , pp. 736-742
    • Krieglstein, K.1    Suter-Crazzolara, C.2    Fischer, W.H.3    Unsicker, K.4
  • 26
    • 0035141207 scopus 로고    scopus 로고
    • EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
    • Liu, A. and Joyner, A. L. (2001). EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development 128, 181-191.
    • (2001) Development , vol.128 , pp. 181-191
    • Liu, A.1    Joyner, A.L.2
  • 28
    • 0029913105 scopus 로고    scopus 로고
    • The engrailed and huckebein genes are essential for development of serotonin neurons in the Drosophila CNS
    • Lundell, M. J., Chu-LaGraff, Q., Doe, C. Q. and Hirsh, J. (1996). The engrailed and huckebein genes are essential for development of serotonin neurons in the Drosophila CNS. Mol. Cell Neurosci. 7, 46-61.
    • (1996) Mol. Cell Neurosci. , vol.7 , pp. 46-61
    • Lundell, M.J.1    Chu-LaGraff, Q.2    Doe, C.Q.3    Hirsh, J.4
  • 29
    • 0027956162 scopus 로고
    • Apoptosis in substantia nigra following developmental striatal excitotoxic injury
    • Macaya, A., Munell, F., Gubits, R. M. and Burke, R. E. (1994). Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc. Natl. Acad. Sci. USA 91, 8117-8121.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8117-8121
    • Macaya, A.1    Munell, F.2    Gubits, R.M.3    Burke, R.E.4
  • 30
    • 0036469291 scopus 로고    scopus 로고
    • Persistent engrailed expression is required to determine sensory axon trajectory, branching, and target choice
    • Marie, B., Cruz-Orengo, L. and Blagburn, J. M. (2002). Persistent engrailed expression is required to determine sensory axon trajectory, branching, and target choice. J. Neurosci. 22, 832-841.
    • (2002) J. Neurosci. , vol.22 , pp. 832-841
    • Marie, B.1    Cruz-Orengo, L.2    Blagburn, J.M.3
  • 31
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • Mochizuki, H., Goto, K., Mori, H. and Mizuno, Y. (1996). Histochemical detection of apoptosis in Parkinson's disease. J. Neurol. Sci. 137, 120-123.
    • (1996) J. Neurol. Sci. , vol.137 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 33
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Olanow, C. W. and Tatton, W. G. (1999). Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 22, 123-144.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 123-144
    • Olanow, C.W.1    Tatton, W.G.2
  • 34
    • 0032055973 scopus 로고    scopus 로고
    • Neuronal cell death
    • Pettmann, B. and Henderson, C. E. (1998). Neuronal cell death. Neuron 20, 633-647.
    • (1998) Neuron , vol.20 , pp. 633-647
    • Pettmann, B.1    Henderson, C.E.2
  • 35
    • 0032913951 scopus 로고    scopus 로고
    • The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins
    • Piccini, P., Burn, D. J., Ceravolo, R., Maraganore, D. and Brooks, D. J. (1999). The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann. Neurol. 45, 577-582.
    • (1999) Ann. Neurol. , vol.45 , pp. 577-582
    • Piccini, P.1    Burn, D.J.2    Ceravolo, R.3    Maraganore, D.4    Brooks, D.J.5
  • 36
    • 0032584085 scopus 로고    scopus 로고
    • Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    • Saucedo-Cardenas, O., Quintana-Hau, J. D., Le, W. D., Smidt, M. P., Cox, J. J., de Mayo, F., Burbach, J. P. and Conneely, O. M. (1998). Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4013-4018
    • Saucedo-Cardenas, O.1    Quintana-Hau, J.D.2    Le, W.D.3    Smidt, M.P.4    Cox, J.J.5    de Mayo, F.6    Burbach, J.P.7    Conneely, O.M.8
  • 37
    • 0032709502 scopus 로고    scopus 로고
    • Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons
    • Saueressig, H., Burrill, J. and Goulding, M. (1999). Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. Development 126, 4201-4212.
    • (1999) Development , vol.126 , pp. 4201-4212
    • Saueressig, H.1    Burrill, J.2    Goulding, M.3
  • 38
    • 0034234546 scopus 로고    scopus 로고
    • Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice
    • Semina, E. V., Murray, J. C., Reiter, R., Hrstka, R. F. and Graw, J. (2000). Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice. Hum. Mol. Genet. 9, 1575-1585.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1575-1585
    • Semina, E.V.1    Murray, J.C.2    Reiter, R.3    Hrstka, R.F.4    Graw, J.5
  • 39
    • 0035341443 scopus 로고    scopus 로고
    • Fate of midbrain dopaminergic neurons controlled by the Engrailed genes
    • Simon, H. H., Saueressig, H., Wurst, W., Goulding, M. D. and O'Leary, D. D. (2001). Fate of midbrain dopaminergic neurons controlled by the Engrailed genes. J. Neurosci. 21, 3126-3134.
    • (2001) J. Neurosci. , vol.21 , pp. 3126-3134
    • Simon, H.H.1    Saueressig, H.2    Wurst, W.3    Goulding, M.D.4    O'Leary, D.D.5
  • 40
    • 0034034739 scopus 로고    scopus 로고
    • A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    • Smidt, M. P., Asbreuk, C. H., Cox, J. J., Chen, H., Johnson, R. L. and Burbach, J. P. (2000). A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat. Neurosci. 3, 337-341.
    • (2000) Nat. Neurosci. , vol.3 , pp. 337-341
    • Smidt, M.P.1    Asbreuk, C.H.2    Cox, J.J.3    Chen, H.4    Johnson, R.L.5    Burbach, J.P.6
  • 42
    • 0024157413 scopus 로고
    • Time course of MPTP-induced degeneration of the nigrostriatal dopamine system in C57 BL/6 mice
    • Sundstrom, E., Luthman, J., Goldstein, M. and Jonsson, G. (1988). Time course of MPTP-induced degeneration of the nigrostriatal dopamine system in C57 BL/6 mice. Brain Res. Bull. 21, 257-263.
    • (1988) Brain Res. Bull. , vol.21 , pp. 257-263
    • Sundstrom, E.1    Luthman, J.2    Goldstein, M.3    Jonsson, G.4
  • 43
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining
    • Tattoo, N. A. and Kish, S. J. (1997). In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77, 1037-1048.
    • (1997) Neuroscience , vol.77 , pp. 1037-1048
    • Tattoo, N.A.1    Kish, S.J.2
  • 44
    • 0031696403 scopus 로고    scopus 로고
    • A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease
    • Tatton, N. A., Maclean-Fraser, A., Tatton, W. G., Perl, D. P. and Olanow, C. W. (1998). A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Ann. Neurol. 44, S142-S148.
    • (1998) Ann. Neurol. , vol.44
    • Tatton, N.A.1    Maclean-Fraser, A.2    Tatton, W.G.3    Perl, D.P.4    Olanow, C.W.5
  • 45
    • 0031013141 scopus 로고    scopus 로고
    • Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
    • Tompkins, M. M., Basgall, E. J., Zamrini, E. and Hill, W. D. (1997) Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am. J. Pathol. 150, 119-131.
    • (1997) Am. J. Pathol. , vol.150 , pp. 119-131
    • Tompkins, M.M.1    Basgall, E.J.2    Zamrini, E.3    Hill, W.D.4
  • 47
    • 0038205745 scopus 로고    scopus 로고
    • Neurological diseases: Targeting programmed cell death in neurodegenerative diseases
    • Vila, M. and Przedborski, S. (2003). Neurological diseases: Targeting programmed cell death in neurodegenerative diseases. Nat. Rev. Neurosci. 4, 365-375.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 365-375
    • Vila, M.1    Przedborski, S.2
  • 48
  • 49
    • 0038526314 scopus 로고    scopus 로고
    • Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
    • Wang, Z., Benoit, G., Liu, J., Prasad, S., Aarnisalo, P., Liu, X., Xu, H., Walker, N. P. and Perlmann, T. (2003). Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 423, 555-560.
    • (2003) Nature , vol.423 , pp. 555-560
    • Wang, Z.1    Benoit, G.2    Liu, J.3    Prasad, S.4    Aarnisalo, P.5    Liu, X.6    Xu, H.7    Walker, N.P.8    Perlmann, T.9
  • 50
    • 0027481926 scopus 로고
    • Differential reaction of crossing and non-crossing rat retinal axons on cell membrane preparations from the chiasm midline: An in vitro study
    • Wizenmann, A., Thanos, S., von Boxberg, Y. and Bonhoeffer, F. (1993). Differential reaction of crossing and non-crossing rat retinal axons on cell membrane preparations from the chiasm midline: an in vitro study. Development 117, 725-735.
    • (1993) Development , vol.117 , pp. 725-735
    • Wizenmann, A.1    Thanos, S.2    von Boxberg, Y.3    Bonhoeffer, F.4
  • 51
    • 0033230199 scopus 로고    scopus 로고
    • Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1
    • Yee, K. T., Simon, H. H., Tessier-Lavigne, M. and O'Leary, D. M. (1999). Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1. Neuron 24, 607-622.
    • (1999) Neuron , vol.24 , pp. 607-622
    • Yee, K.T.1    Simon, H.H.2    Tessier-Lavigne, M.3    O'Leary, D.M.4
  • 53
    • 0034694199 scopus 로고    scopus 로고
    • Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion
    • Zuch, C. L., Nordstroem, V. K., Briedrick, L. A., Hoernig, G. R., Granholm, A. C. and Bickford, P. C. (2000). Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. J. Comp. Neurol. 427, 440-454.
    • (2000) J. Comp. Neurol. , vol.427 , pp. 440-454
    • Zuch, C.L.1    Nordstroem, V.K.2    Briedrick, L.A.3    Hoernig, G.R.4    Granholm, A.C.5    Bickford, P.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.