Tempol reduces the activation of nuclear factor-κB in acute inflammation

Free Radical Research

Volumn 38, Issue 8, 2004, Pages 813-819

  Cuzzocrea, Salvatore ^a   Pisano, Barbara ^b   Dugo, Laura ^c   Ianaro, Angelica ^b   Patel, Nimesh S A ^c   Caputi, Achille P ^a   Thiemermann, Christoph ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Cytokines; Inflammation; NF B; Pleurisy; Tempol

Indexed keywords

ANTIINFLAMMATORY AGENT; CARRAGEENAN; DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; SCAVENGER; TEMPOL; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE INDUCTION; IN VIVO STUDY; INFLAMMATION; LUNG HOMOGENATE; MALE; MEMBRANE PERMEABILITY; MOUSE; NEUTROPHIL; NONHUMAN; PLEURA CAVITY; PLEURA FLUID; PLEURISY; PROTEIN DEGRADATION; SHOCK; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; CARRAGEENAN; CYCLIC N-OXIDES; DNA; I-KAPPA B KINASE; INFLAMMATION; INTERLEUKIN-1; LUNG; MALE; MICE; NF-KAPPA B; PLEURISY; PROTEIN-SERINE-THREONINE KINASES; SPIN LABELS; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4043130209     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760410001710829     Document Type: Article

References (48)

1. Peters, R.T., Liao, S.M. and Maniatis, T. (2000) "IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex", Mol. Cell 5, 513-522.
2. Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J., Tatsumi, Y., Kanamaru, A. and Akira, S. (1999) "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases", Int. Immunol. 11, 1357-1362.
3. Piette, J., Piret, B., Bonizzi, G., Schoonbroodt, S., Merville, M.P., Legrand-Poels, S. and Bours, V. (1997) "Multiple redox regulation in NF-kappaB transcription factor activation", Biol. Chem. 378, 1237-1245.
4. Gius, D., Botero, A., Shah, S. and Curry, H.A. (1999) "Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1", Toxicol. Lett. 106, 93-106.
5. Bowie, A. and O'Neill, L.A. (2000) "Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries", Biochem. Pharmacol. 59, 13-23.
6. 2-induced injury", Lens Eye Toxicol. Res. 9, 385-393.
7. Laight, D.W., Andrews, T.J. and Haj-Yehia, A.I. (1997) "Microassay of superoxide anion scavenging activity in vitro" Environ. Toxicol. Pharm. 3, 65-68.
8. Mitchell, J.B., Samuni, A. and Krishna, M.C. (1990) "Biologically active metal-independent superoxide dismutase mimics", Biochemistry 29, 2802-2807.
9. Bowes, J., McDonald, M.C., Piper, J. and Thiemermann, C. (1999) "Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress", Cardiovasc. Res. 1, 126-134.
10. Carroll, R.T., Galatsis, P., Borosky, S., Kopec, K.K., Kumar, V., Althaus, J.S. and Hall, E.D. (2000) "4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration", Chem. Res. Toxicol. 13, 294-300.
11. Sledzinski, Z., Wozniak, M., Antosiewicz, J., Lezoche, E., Familiari, M., Bertoli, E., Greci, L., Brunelli, A., Mazera, N. and Wajda, Z. (1995) "Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis", Int. J. Pancreatol. 18, 153-160.
12. Rahman, I., Skwarska, E. and Macnee, W. (1997) "Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease", Thorax 52, 565-568.
13. Repine, J.E., Bast, A. and Lankhrst, I. (1997) "The oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease", Am. J. Respir. Crit. Care Med. 156, 341-357.
14. Postma, D.S., Renkema, E.J., Noordhoek, J.A., Faber, H., Sluiter, H.J. and Kauffman, H. (1988) "Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic airflow obstruction", Am. Rev. Respir. Dis. 137, 57-61.
15. Dawson, J., Sedgwick, A.D., Edwards, J.C. and Lees, P.A. (1991) "Comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse", Int. J. Tissue React. 13, 171-185.
16. Cuzzocrea, S., Zingarelli, B., Gilard, E., Hake, P., Salzman, A.L. and Szabó, C. (1998) "Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation", Free Radic. Biol. Med. 24, 450-459.
17. Cuzzocrea, S., Zingarelli, B., Gilard, E., Hake, P., Salzman, A.L. and Szabó, C. (1997) "Protective effect of melatonin in carrageenan-induced models of local inflammation", J. Pineal. Res. 23, 106-116.
18. G-monomethylarginine, reduces carrageenan-induced pleurisy in the rat", J. Pharmacol. Exp. Ther. 273, 1295-1299.
19. Droy-Lefaix, M.T., Drouet, Y., Geraud, G., Hosfod, D. and Braquet, P. (1991) "Superoxide dimutase (SOD) and the PAF-antagonist (BN 52021) reduce small intestinal damage induced by ischemia-reperfusion", Free Radic. Res. Commun. 12, 725-735.
20. Haglind, E., Xia, G. and Rylander, R. (1994) "Effects of antioxidants and PAF receptor antagonist in intestinal shock in the rat", Circ. Shock 42, 83-91.
21. Fantone, J.C. and Ward, P.A. (1982) "A review: role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions", Am. J. Pathol. 107, 395-418.
22. Deitch, E.A., Bridges, W., Berg, R., Specian, R.D. and Granger, N. (1990) "Hernorrhagic shock-induced bacterial translocation: the role of neutrophils and hydroxyl radicals", J. Trauma 30, 942-951.
23. Boughton-Smith, N.K., Evans, S.M., Laszlo, F., Whittle, B.J. and Moncada, S. (1993) "The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat", Br. J. Pharmacol. 110, 1189-1195.
24. Salvemini, D., Riley, D.P., Lennon, P.J., Wang, Z.Q., Currie, M.G., Macarthur, H. and Misko, T.P. (1999) "Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage", Br. J. Pharmacol. 127, 685-692.
25. Dix, T.A., Hess, K.M., Medina, M.A., Sullivan, R.W., Tilly, S.L. and Webb, T.L. (1996) "Mechanism of site-selective DNA nicking by the hydrodioxyl (perhydroxyl) radical", Biochemistry 35, 4578-4583.
26. Ischiropoulos, H., Zhu, L. and Beckman, I.S. (1992) "Peroxynitrite formation from macrophage-derived nitric oxide" , Arch. Biochem. Biophys. 298, 446-451.
27. Salvemini, D., Jensen, M.P., Riley, D.P. and Misko, T.P. (1998) "Therapeutic manipulations of peroxynitrite", Drug News Perspect. 11, 204-214.
28. Kamata, H. and Hirata, H. (1999) "Redox regulation of cellular signaling", Cell. Signal. 11, 1-14.
29. Roberts, M.L. and Cowsert, L.M. (1998) "Interleukin-1 beta and reactive oxygen species mediate activation of c-Jun NH2-terminal kinases, in human epithelial cells, by two independent pathways", Biochem. Biophys. Res. Commun. 251, 166-172.
30. Chen, Z.J., Parent, L. and Maniatis, T. (1996) "Site-specific phosphorylation of I kappa B alpha by a novel ubiquitination-dependent protein kinase activity", Cell 84, 853-862.
31. Flohe, L., Brigelius-Flohe, R., Saliou, C., Traber, M.G. and Packer, L. (1997) "Redox regulation of NF-kB activation", Free Radic. Biol. Med. 22, 1115-1126.
32. Barnes, P.J. and Adcock, I.M. (1997) "NF-kappa B: a pivotal role in asthma and a new target for therapy", Trends Pharmacol. Sci. 18, 46-50.
33. Chen, F., Castranova, V., Shi, X. and Demers, L.M. (1999) "New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases", Clin. Chem. 45, 7-17.
34. Siebenlist, U., Franzoso, G. and Brown, K. (1994) "Structure, regulation and function of NF-kappa B", Annu. Rev. Cell Biol. 10, 405-455.
35. Blackwell, T.S., Blackwell, T.R., Holden, E.P., Christman, B.W. and Christman, J.W. (1996) "In vivo antioxidant treatment suppresses nuclear factor-kappa B activation an neutrophilic lung inflammation", J. Immunol. 157, 1630-1637.
36. Chandrasekar, B., Streitman, J.E., Colston, J.T. and Freeman, G.L. (1998) "Inhibition of nuclear factor kappa B attenuates proinflammatory cytokine and inducible nitric-oxide synthase expression in postischemic myocardium", Biochim. Biophys. Acta 1406, 91-106.
37. Lentsch, A.B., Shanley, T.P., Sarma, V. and Ward, P.A. (1997) "In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13", J. Clin. Investig. 100, 2443-2448.
38. Liu, S.F., Ye, X. and Malik, A.B. (1997) "In vivo inhibition of nuclear factor-kB activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock" , J. Immunol. 159, 3976-3983.
39. Munoz, C., Pascual-Salcedo, D., Castellanos, M.C., Alfranca, A., Aragones, J. and Vara, A. (1996) "Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kB and AP-1 transcription factors activity", Blood 88, 3482-3490.
40. Xie, Q.W., Kashiwabara, Y. and Nathan, C. (1994) "Role of transcription factor NF-kB/Rel in induction of nitric oxide synthase", J. Biol. Chem. 269, 4705-4708.
41. Ghosh, S. and Baltimore, D. (1990) "Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB", Nature 344, 678-682.
42. Kolesnick, R. and Goled, D.W. (1994) "The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling", Cell 77, 325-328.
43. Novogrodsky, A., Vanichkin, A., Patya, M., Gazit, A., Osherov, N. and Levitzki, A. (1994) "Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors", Science 264, 1319-1322.
44. Schultze, S., Machleid, T. and Kronke, M. (1994) "The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction", J. Leukoc. Biol. 56, 533-541.
45. Piguet, P.F., Grau, G.E., Vesin, C., Loetscher, H., Genz, R. and Lesslauer, W. (1992) "Evolution of collagen arthritis is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor", J. Immunol. 77, 510-514.
46. Saklatvala, J. (1986) "Tumour necrosis factor a stimulates resorption and inhibits synthesis of proteoglycan in cartilage", Nature 322, 547-549.
47. Yoshizumi, M., Fujita, Y., Izawa, Y., Suzaki, Y., Kyaw, M., Ali, N., Tsuchiya, K., Kagami, S., Yano, S., Sone, S. and Tamaki, T. (2004) "Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells", Exp. Cell Res. 292, 1-10.
48. Zhang, H.G., Hyde, K., Page, G.P., Brand, J.P., Zhou, J., Yu, S., Allison, D.B., Hsu, H.C. and Mountz, J.D. (2004) "Novel tumor necrosis factor alpha-regulated genes in rheumatoid arthritis", Arthritis Rheum. 50(2), 420-431.