-
1
-
-
0029888319
-
Management of deep-vein thrombosis and pulmonary embolism. A statement for healthcare professionals. Council on Thrombosis
-
(in consultation with the Council on Cardiovascular Radiology), American Heart Association
-
Hirsh J, Hoak J. Management of deep-vein thrombosis and pulmonary embolism. A statement for healthcare professionals. Council on Thrombosis (in consultation with the Council on Cardiovascular Radiology), American Heart Association. Circulation 93, 2212-2245 (1996).
-
(1996)
Circulation
, vol.93
, pp. 2212-2245
-
-
Hirsh, J.1
Hoak, J.2
-
2
-
-
0027123107
-
Molecular and cellular biology of blood coagulation
-
Furie B, Furie BC. Molecular and cellular biology of blood coagulation. N. Engl. J. Med. 326, 800-806 (1992).
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 800-806
-
-
Furie, B.1
Furie, B.C.2
-
3
-
-
0141862288
-
Novel anticoagulant agents: Introduction
-
Schulman S. Novel anticoagulant agents: introduction. J. Intern. Med. 254, 308-312 (2003).
-
(2003)
J. Intern. Med.
, vol.254
, pp. 308-312
-
-
Schulman, S.1
-
4
-
-
0141862287
-
Recombinant nematode anticoagulant protein C2 and other inhibitors targeting blood coagulation Factor VIIa/tissue factor
-
Lee AY, Vlasuk GP. Recombinant nematode anticoagulant protein C2 and other inhibitors targeting blood coagulation Factor VIIa/tissue factor. J. Intern. Med. 254, 313-321 (2003).
-
(2003)
J. Intern. Med.
, vol.254
, pp. 313-321
-
-
Lee, A.Y.1
Vlasuk, G.P.2
-
5
-
-
0141750717
-
Oral direct thrombin inhibitors in clinical development
-
Gustafsson D. Oral direct thrombin inhibitors in clinical development. J. Intern. Med. 254, 322-334 (2003).
-
(2003)
J. Intern. Med.
, vol.254
, pp. 322-334
-
-
Gustafsson, D.1
-
6
-
-
0026434005
-
Heparin
-
Hirsh J. Heparin. N. Engl. J. Med. 324, 1565-1574 (1991).
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 1565-1574
-
-
Hirsh, J.1
-
7
-
-
0026432629
-
Oral anticoagulant drugs
-
Hirsh J. Oral anticoagulant drugs. N. Engl. J. Med. 324, 1865-1875 (1991).
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 1865-1875
-
-
Hirsh, J.1
-
8
-
-
0031729679
-
Oral anticoagulants: Mechanism of action, clinical effectiveness and optimal therapeutic range
-
Hirsh J, Dalen JE, Anderson DR et al. Oral anticoagulants: mechanism of action, clinical effectiveness and optimal therapeutic range. Chest 114, S445-S469 (1998).
-
(1998)
Chest
, vol.114
-
-
Hirsh, J.1
Dalen, J.E.2
Anderson, D.R.3
-
9
-
-
0028785452
-
Heparin: Mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy and safety
-
Hirsh J, Raschke R, Warkentin TE et al. Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy and safety. Chest 108, S258-S275 (1995).
-
(1995)
Chest
, vol.108
-
-
Hirsh, J.1
Raschke, R.2
Warkentin, T.E.3
-
10
-
-
15844427401
-
Bleeding complications of oral anticoagulant treatment: Inception-cohort, prospective collaborative study (ISCOAT)
-
Palareti G, Leali N. Bleeding complications of oral anticoagulant treatment: inception-cohort, prospective collaborative study (ISCOAT). Lancet 348, 423-428 (1996).
-
(1996)
Lancet
, vol.348
, pp. 423-428
-
-
Palareti, G.1
Leali, N.2
-
11
-
-
0034723739
-
Oral anticoagulation treatment in the elderly: A nested, prospective, case-control study
-
Palareti G, Hirsh J, Legnani C et al. Oral anticoagulation treatment in the elderly: a nested, prospective, case-control study. Arch. Intern. Med. 28, 470-478 (2000).
-
(2000)
Arch. Intern. Med.
, vol.28
, pp. 470-478
-
-
Palareti, G.1
Hirsh, J.2
Legnani, C.3
-
12
-
-
0029969612
-
Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administrated at home
-
The Tasman Study Group
-
Koopman MM, Prandoni P, Piovella F et al. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administrated at home. The Tasman Study Group. N. Engl. J. Med. 334, 682-687 (1996).
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 682-687
-
-
Koopman, M.M.1
Prandoni, P.2
Piovella, F.3
-
13
-
-
0006590545
-
A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis
-
Levine M, Gent M, Hirsh J et al. A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N. Engl. J. Med. 334, 677-681 (1996).
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 677-681
-
-
Levine, M.1
Gent, M.2
Hirsh, J.3
-
14
-
-
0025146426
-
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors
-
Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J. Clin. Invest. 86, 385-391 (1990).
-
(1990)
J. Clin. Invest.
, vol.86
, pp. 385-391
-
-
Weitz, J.I.1
Hudoba, M.2
Massel, D.3
Maraganore, J.4
Hirsh, J.5
-
15
-
-
0346969977
-
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
-
Girardi G, Berman J, Redecha P et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J. Clin. Invest. 112, 1644-1654 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1644-1654
-
-
Girardi, G.1
Berman, J.2
Redecha, P.3
-
16
-
-
0026762705
-
Lower mortality in cancer patients treated with low-molecular-weight versus standard heparin
-
Green D, Hull RD, Brant R, Pineo GF. Lower mortality in cancer patients treated with low-molecular-weight versus standard heparin. Lancet 339, 1476 (1992).
-
(1992)
Lancet
, vol.339
, pp. 1476
-
-
Green, D.1
Hull, R.D.2
Brant, R.3
Pineo, G.F.4
-
17
-
-
0026569416
-
Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis
-
Prandoni P, Lensing AW, Buller HR et al. Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis. Lancet 339, 441-445 (1992).
-
(1992)
Lancet
, vol.339
, pp. 441-445
-
-
Prandoni, P.1
Lensing, A.W.2
Buller, H.R.3
-
18
-
-
0029925784
-
Low-molecular-weight heparins and unfractionated heparin in the treatment of patients with acute venous thromboembolism: Results of a meta-analysis
-
Siragusa S, Cosmi B, Piovella F, Hirsh J, Ginsberg JS. Low-molecular-weight heparins and unfractionated heparin in the treatment of patients with acute venous thromboembolism: results of a meta-analysis. Am. J. Med. 100, 269-277 (1996).
-
(1996)
Am. J. Med.
, vol.100
, pp. 269-277
-
-
Siragusa, S.1
Cosmi, B.2
Piovella, F.3
Hirsh, J.4
Ginsberg, J.S.5
-
19
-
-
0032955744
-
Low-molecular-weight hepatitis compared with unfractionated heparin for treatment of acute deep-venous thrombosis: A meta-analysis of randomized, controlled trials
-
Gould MK, Dembitzer AD, Doyle RL, Hastie TJ, Garber AM. Low-molecular-weight hepatitis compared with unfractionated heparin for treatment of acute deep-venous thrombosis: a meta-analysis of randomized, controlled trials. Ann. Intern. Med. 130, 800-809 (1999).
-
(1999)
Ann. Intern. Med.
, vol.130
, pp. 800-809
-
-
Gould, M.K.1
Dembitzer, A.D.2
Doyle, R.L.3
Hastie, T.J.4
Garber, A.M.5
-
20
-
-
0242469234
-
Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight
-
Khorana AA, Sahni A, Aldand OD, Francis CW. Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight. Arterioscler. Thromb. Vasc. Biol. 23, 2110-2115 (2003).
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 2110-2115
-
-
Khorana, A.A.1
Sahni, A.2
Aldand, O.D.3
Francis, C.W.4
-
21
-
-
0000983222
-
The thromboplastic action of cephalin
-
McLean J. The thromboplastic action of cephalin. Am. J. Physiol. 41, 250-257 (1916).
-
(1916)
Am. J. Physiol.
, vol.41
, pp. 250-257
-
-
McLean, J.1
-
22
-
-
0000420311
-
Two new factors in blood coagulation - Heparin and proantithrombin
-
Howell WH, Holt E. Two new factors in blood coagulation - heparin and proantithrombin. Am. J. Physiol. 47, 328-341 (1918).
-
(1918)
Am. J. Physiol.
, vol.47
, pp. 328-341
-
-
Howell, W.H.1
Holt, E.2
-
23
-
-
0141833778
-
The anticoagulant from spoiled sweet-clover hay
-
Link KP. The anticoagulant from spoiled sweet-clover hay. Harvey Lectures 39, 152-216 (1943).
-
(1943)
Harvey Lectures
, vol.39
, pp. 152-216
-
-
Link, K.P.1
-
24
-
-
0346435111
-
A brief historical review of the waterfall/cascade of blood coagulation
-
Davie EW. A brief historical review of the waterfall/cascade of blood coagulation. J. Biol. Chem. 278, 50819-50832 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50819-50832
-
-
Davie, E.W.1
-
25
-
-
0141707881
-
Thrombin formation
-
Mann KG. Thrombin formation. Chest 124(Suppl. 3), S4-S10 (2003).
-
(2003)
Chest
, vol.124
, Issue.SUPPL. 3
-
-
Mann, K.G.1
-
26
-
-
2342478700
-
Tissue factor in at the start and the finish?
-
Morrissey JH. Tissue factor in at the start and the finish? J. Thromb. Haemost. 1, 878-880 (2003).
-
(2003)
J. Thromb. Haemost.
, vol.1
, pp. 878-880
-
-
Morrissey, J.H.1
-
28
-
-
0029082791
-
Tissue factor pathway inhibitor
-
Broze GJ. Tissue factor pathway inhibitor. Thromb. Haemost. 74, 90-93 (1995).
-
(1995)
Thromb. Haemost.
, vol.74
, pp. 90-93
-
-
Broze, G.J.1
-
29
-
-
0141535106
-
Tissue factor pathway inhibitors as a novel approach to antithrombotic therapy
-
Sajadi S, Ezekowitz MD, Dhond A, Netrebko P. Tissue factor pathway inhibitors as a novel approach to antithrombotic therapy. Drug News Perspect. 16, 363-369 (2003).
-
(2003)
Drug News Perspect.
, vol.16
, pp. 363-369
-
-
Sajadi, S.1
Ezekowitz, M.D.2
Dhond, A.3
Netrebko, P.4
-
30
-
-
0141862287
-
Recombinant nematode anticoagulant protein C2 and other inhibitors targeting blood coagulation Factor VIIa/tissue factor
-
Lee AY, Vlasuk GP. Recombinant nematode anticoagulant protein C2 and other inhibitors targeting blood coagulation Factor VIIa/tissue factor. J. Intern. Med. 254, 312-321 (2003).
-
(2003)
J. Intern. Med.
, vol.254
, pp. 312-321
-
-
Lee, A.Y.1
Vlasuk, G.P.2
-
31
-
-
0037026484
-
RNA aptamers as reversible antagonists of coagulation Factor IXa
-
Rusconi CP, Scardino E, Layzer J et al. RNA aptamers as reversible antagonists of coagulation Factor IXa. Nature 419, 90-94 (2002).
-
(2002)
Nature
, vol.419
, pp. 90-94
-
-
Rusconi, C.P.1
Scardino, E.2
Layzer, J.3
-
33
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
-
Bernard GR, Vincent JL, Laterre PF et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344, 699-709 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
-
34
-
-
0035992710
-
Activated protein C: Potential therapy for severe sepsis, thrombosis and stroke
-
Griffin JH, Zlokovic B, Fernandez JA. Activated protein C: potential therapy for severe sepsis, thrombosis and stroke. Semin. Hematol. 39, 197-205 (2002).
-
(2002)
Semin. Hematol.
, vol.39
, pp. 197-205
-
-
Griffin, J.H.1
Zlokovic, B.2
Fernandez, J.A.3
-
35
-
-
0036588770
-
Direct thrombin inhibitors
-
Weitz JI, Crowther M. Direct thrombin inhibitors. Thromb. Res. 106, 275-284 (2002).
-
(2002)
Thromb. Res.
, vol.106
, pp. 275-284
-
-
Weitz, J.I.1
Crowther, M.2
-
36
-
-
0037176941
-
Direct thrombin inhibitors in acute coronary syndromes: Present and future
-
Weitz JI, Buller HR. Direct thrombin inhibitors in acute coronary syndromes: present and future. Circulation 105, 1004-1011 (2002).
-
(2002)
Circulation
, vol.105
, pp. 1004-1011
-
-
Weitz, J.I.1
Buller, H.R.2
-
37
-
-
0014387428
-
The relationship between the structure of a thrombus or a hemostatic plug and the mechanisms involved in its formation
-
Mustard JF. The relationship between the structure of a thrombus or a hemostatic plug and the mechanisms involved in its formation. Thromb. Diath. Haemorrha. 28(Suppl.), 57-64 (1968).
-
(1968)
Thromb. Diath. Haemorrha.
, vol.28
, Issue.SUPPL.
, pp. 57-64
-
-
Mustard, J.F.1
-
38
-
-
0033586986
-
Vascular bed specific hemostasis and hypercoagulable state
-
Rosenberg RD, Aird WC. Vascular bed specific hemostasis and hypercoagulable state. N. Engl. J. Med. 340, 1555-1564 (1999).
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1555-1564
-
-
Rosenberg, R.D.1
Aird, W.C.2
-
39
-
-
0035128503
-
Oral anticoagulants: Mechanism of action, clinical effectiveness and optimal therapeutic range
-
Hirsh J, Dalen J, Anderson DR et al. Oral anticoagulants: mechanism of action, clinical effectiveness and optimal therapeutic range. Chest 119, S8-S21 (2001).
-
(2001)
Chest
, vol.119
-
-
Hirsh, J.1
Dalen, J.2
Anderson, D.R.3
-
40
-
-
0035125405
-
Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy and safety
-
Hirsh J, Warkentin TE, Shaughnessy SG et al. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy and safety. Chest 119, S64-S94 (2001).
-
(2001)
Chest
, vol.119
-
-
Hirsh, J.1
Warkentin, T.E.2
Shaughnessy, S.G.3
-
41
-
-
0033954572
-
The emerging role of low-molecular-weight heparin in cardiovascular medicine
-
Hirsh J, Bates SM. The emerging role of low-molecular-weight heparin in cardiovascular medicine. Prog. Cardiovasc. Dis. 42, 235-246 (2000).
-
(2000)
Prog. Cardiovasc. Dis.
, vol.42
, pp. 235-246
-
-
Hirsh, J.1
Bates, S.M.2
-
42
-
-
0030858230
-
Low-molecular-weight hepatitis
-
Weitz JI. Low-molecular-weight hepatitis. N. Engl. J. Med. 337, 688-698 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 688-698
-
-
Weitz, J.I.1
-
43
-
-
0021061174
-
Structure activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-Factor Xa activity
-
Choay J, Petitou M, Lormeau JC et al. Structure activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-Factor Xa activity. Biochem. Biophys. Res. Comm. 116, 492-499 (1983).
-
(1983)
Biochem. Biophys. Res. Comm.
, vol.116
, pp. 492-499
-
-
Choay, J.1
Petitou, M.2
Lormeau, J.C.3
-
44
-
-
0037239007
-
Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide (fondaparinux)
-
Samama MM, Gerotziafas GT. Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide (fondaparinux). Thromb. Res. 109, 1-11 (2003).
-
(2003)
Thromb. Res.
, vol.109
, pp. 1-11
-
-
Samama, M.M.1
Gerotziafas, G.T.2
-
45
-
-
0026690347
-
Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement
-
Olson ST, Björk I, Sheffer R et al. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J. Biol. Chem. 267, 12528-12538 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 12528-12538
-
-
Olson, S.T.1
Björk, I.2
Sheffer, R.3
-
46
-
-
0036195867
-
Fondaparinux: A synthetic heparin pentasaccharide as a new antithrombotic agent
-
Walenga JM, Jeske WP, Samama MM et al. Fondaparinux: a synthetic heparin pentasaccharide as a new antithrombotic agent. Expert Opin. Investig. Drugs 11(3), 397-407 (2002).
-
(2002)
Expert Opin. Investig. Drugs
, vol.11
, Issue.3
, pp. 397-407
-
-
Walenga, J.M.1
Jeske, W.P.2
Samama, M.M.3
-
47
-
-
0023214250
-
Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges
-
Walenga JM, Petitou M, Lormeau JC et al. Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges. Thromb. Res. 46, 187-198 (1987).
-
(1987)
Thromb. Res.
, vol.46
, pp. 187-198
-
-
Walenga, J.M.1
Petitou, M.2
Lormeau, J.C.3
-
48
-
-
0030035480
-
Antithrombin-mediated inhibition of Factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin
-
Lormeau JC, Herault JP, Herbert JM. Antithrombin-mediated inhibition of Factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin. Thromb. Haemost. 76, 5-8 (1996).
-
(1996)
Thromb. Haemost.
, vol.76
, pp. 5-8
-
-
Lormeau, J.C.1
Herault, J.P.2
Herbert, J.M.3
-
49
-
-
0024436366
-
Free Factor Xa is on the main pathway of thrombin generation in dotting plasma
-
Hemker HC, Choay J, Beguin S. Free Factor Xa is on the main pathway of thrombin generation in dotting plasma. Biochem. Biophys. Acta 992, 409-411 (1989).
-
(1989)
Biochem. Biophys. Acta
, vol.992
, pp. 409-411
-
-
Hemker, H.C.1
Choay, J.2
Beguin, S.3
-
50
-
-
0030772346
-
Comparative effects of two direct and indirect Factor Xa inhibitors on free and clot-bound prothrombinase
-
Herault JP, Bernat A, Pflieger AM, Lormeau JC, Herbert JM. Comparative effects of two direct and indirect Factor Xa inhibitors on free and clot-bound prothrombinase. J. Pharmacol. Exp. Ther. 283, 16-22 (1997).
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 16-22
-
-
Herault, J.P.1
Bernat, A.2
Pflieger, A.M.3
Lormeau, J.C.4
Herbert, J.M.5
-
51
-
-
0036395978
-
The pharmacokinetics of fondaparinux sodium in healthy volunteers
-
Donat F, Duret JP, Santoni A et al. The pharmacokinetics of fondaparinux sodium in healthy volunteers. Clin. Pharmacokinet. 41(Suppl. 2), 1-9 (2002).
-
(2002)
Clin. Pharmacokinet.
, vol.41
, Issue.SUPPL. 2
, pp. 1-9
-
-
Donat, F.1
Duret, J.P.2
Santoni, A.3
-
52
-
-
0037129742
-
Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: A randomised double-blind comparison
-
Lassen MR, Bauer KA, Eriksson BI, Turpie AG. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: a randomised double-blind comparison. Lancet 359, 1715-1720 (2002).
-
(2002)
Lancet
, vol.359
, pp. 1715-1720
-
-
Lassen, M.R.1
Bauer, K.A.2
Eriksson, B.I.3
Turpie, A.G.4
-
53
-
-
0037129720
-
Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: A randomised double-blind trial
-
Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial. Lancet 359, 1721-1726 (2002).
-
(2002)
Lancet
, vol.359
, pp. 1721-1726
-
-
Turpie, A.G.1
Bauer, K.A.2
Eriksson, B.I.3
Lassen, M.R.4
-
54
-
-
0035522304
-
Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery
-
Bauer KA, Eriksson BI, Lassen MR, Turpie AG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. N. Engl. J. Med. 345, 1305-1310 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1305-1310
-
-
Bauer, K.A.1
Eriksson, B.I.2
Lassen, M.R.3
Turpie, A.G.4
-
55
-
-
0035522302
-
Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery
-
Eriksson BI, Bauer KA, Lassen MR, Turpie AG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N. Engl. J. Med. 345, 1298-1304 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1298-1304
-
-
Eriksson, B.I.1
Bauer, K.A.2
Lassen, M.R.3
Turpie, A.G.4
-
56
-
-
0028798995
-
Absence of in vitro cross-reaction of pentasaccharide with the plasma heparin dependent factor of twenty-five patients with heparin-associated thrombocytopenia
-
Elalamy I, Lecrubier C, Potevin F et al. Absence of in vitro cross-reaction of pentasaccharide with the plasma heparin dependent factor of twenty-five patients with heparin-associated thrombocytopenia. Thromb. Haemost. 74, 1384-1385 (1995).
-
(1995)
Thromb. Haemost.
, vol.74
, pp. 1384-1385
-
-
Elalamy, I.1
Lecrubier, C.2
Potevin, F.3
-
57
-
-
0028913873
-
Synthetic analogues of the antithrombin III-binding pentasaccharide sequence of heparin. Prediction of in vitro residence time
-
Van Amsterdam R, Vogel G, Visser A et al. Synthetic analogues of the antithrombin III-binding pentasaccharide sequence of heparin. Prediction of in vitro residence time. Arter. Thromb. Vasc. Biol. 15, 495-503 (1995).
-
(1995)
Arter. Thromb. Vasc. Biol.
, vol.15
, pp. 495-503
-
-
Van Amsterdam, R.1
Vogel, G.2
Visser, A.3
-
58
-
-
0029794151
-
Biochemical and pharmacological properties of SANORG 32701. Comparison with the 'synthetic pentasaccharide' (SR 90107/ORG 31540) and standard heparin
-
Herbert JM, Herault JP, Bernat A et al. Biochemical and pharmacological properties of SANORG 32701. Comparison with the 'synthetic pentasaccharide' (SR 90107/ORG 31540) and standard heparin. Circ. Res. 79, 590-600 (1996).
-
(1996)
Circ. Res.
, vol.79
, pp. 590-600
-
-
Herbert, J.M.1
Herault, J.P.2
Bernat, A.3
-
59
-
-
0012652251
-
A novel long-acting synthetic Factor Xa inhibitor (idraparinux sodium) to replace warfarin for secondary prevention in deep-vein thrombosis. A Phase II evaluation
-
PERSIST Investigators
-
PERSIST Investigators. A novel long-acting synthetic Factor Xa inhibitor (idraparinux sodium) to replace warfarin for secondary prevention in deep-vein thrombosis. A Phase II evaluation. Blood 100, 301 (2002).
-
(2002)
Blood
, vol.100
, pp. 301
-
-
-
60
-
-
0030667455
-
Inhibition of thrombin generation in plasma by inhibitors of Factor Xa
-
Prasa D, Svendsen L, Sturzebecher J. Inhibition of thrombin generation in plasma by inhibitors of Factor Xa. Thromb. Haemost. 78, 1215-1220 (1997).
-
(1997)
Thromb. Haemost.
, vol.78
, pp. 1215-1220
-
-
Prasa, D.1
Svendsen, L.2
Sturzebecher, J.3
-
61
-
-
0033373234
-
Inactivation of Factor Xa by the synthetic inhibitor DX-9065a causes strong anticoagulant and antiplatelet actions in human blood
-
Kaiser B, Jeske W, Walenga JM, Fareed J. Inactivation of Factor Xa by the synthetic inhibitor DX-9065a causes strong anticoagulant and antiplatelet actions in human blood. Blood Coag. Fibrinolysis 10, 495-501 (1999).
-
(1999)
Blood Coag. Fibrinolysis
, vol.10
, pp. 495-501
-
-
Kaiser, B.1
Jeske, W.2
Walenga, J.M.3
Fareed, J.4
-
62
-
-
0037217951
-
Global anticoagulant effects of a synthetic anti-Factor Xa inhibitor (DX-9065a): Implications for interventional use
-
Tobu M, Iqbal O, Ma Q et al. Global anticoagulant effects of a synthetic anti-Factor Xa inhibitor (DX-9065a): implications for interventional use. Clin. Appl. Thromb. Hemost. 9, 1-17 (2003).
-
(2003)
Clin. Appl. Thromb. Hemost.
, vol.9
, pp. 1-17
-
-
Tobu, M.1
Iqbal, O.2
Ma, Q.3
-
63
-
-
0001146972
-
The action of a secretion obtained from the medicinal leech on the coagulation of the blood
-
Haycraft JB. The action of a secretion obtained from the medicinal leech on the coagulation of the blood. Proc. R. Soc. Lond. 36, 478-487 (1884).
-
(1884)
Proc. R. Soc. Lond.
, vol.36
, pp. 478-487
-
-
Haycraft, J.B.1
-
65
-
-
0022521744
-
Kinetics of inhibition of thrombin by hirudin
-
Stone SR, Hofsteenge J. Kinetics of inhibition of thrombin by hirudin. Biochemistry 25, 4622-4628 (1986).
-
(1986)
Biochemistry
, vol.25
, pp. 4622-4628
-
-
Stone, S.R.1
Hofsteenge, J.2
-
66
-
-
0025329390
-
The structure of a complex of recombinant hirudin and human α -thrombin
-
Rydel TJ, Ravichandran KG, Tulinsky A et al. The structure of a complex of recombinant hirudin and human α-thrombin. Science 249, 277-280 (1990).
-
(1990)
Science
, vol.249
, pp. 277-280
-
-
Rydel, T.J.1
Ravichandran, K.G.2
Tulinsky, A.3
-
67
-
-
0034307370
-
Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: Incidence, effects on aPTT and clinical relevance
-
Eichler P, Friesen HJ, Lubenow N et al. Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: incidence, effects on aPTT and clinical relevance. Blood 96, 2373-2378 (2000).
-
(2000)
Blood
, vol.96
, pp. 2373-2378
-
-
Eichler, P.1
Friesen, H.J.2
Lubenow, N.3
-
68
-
-
0025346345
-
Design and characterisation of hirulogs: A novel class of bivalent peptide inhibitors of thrombin
-
Maraganore JM, Bourdon P, Jablonski J, Ramachandran KL, Fenton JW. Design and characterisation of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. Biochemistry 29, 7095-7101 (1990).
-
(1990)
Biochemistry
, vol.29
, pp. 7095-7101
-
-
Maraganore, J.M.1
Bourdon, P.2
Jablonski, J.3
Ramachandran, K.L.4
Fenton, J.W.5
-
69
-
-
0034098236
-
Bivalirudin: A new generation antithrombotic drug
-
Scatena R. Bivalirudin: a new generation antithrombotic drug. Expert Opin. Investig. Drugs 9(9), 1119-1127 (2000).
-
(2000)
Expert Opin. Investig. Drugs
, vol.9
, Issue.9
, pp. 1119-1127
-
-
Scatena, R.1
-
70
-
-
0141594931
-
Bivalirudin provides increasing benefit with decreasing renal function: A meta-analysis of randomized trials
-
Chew DP, Bhatt DL, Kimball W et al. Bivalirudin provides increasing benefit with decreasing renal function: a meta-analysis of randomized trials. Am. J. Cardiol. 92, 919-923, (2003).
-
(2003)
Am. J. Cardiol.
, vol.92
, pp. 919-923
-
-
Chew, D.P.1
Bhatt, D.L.2
Kimball, W.3
-
71
-
-
0032738541
-
Clinical outcomes of bivalirudin for ischemic heart disease
-
Kong DF, Topol EJ, Bittl JA et al. Clinical outcomes of bivalirudin for ischemic heart disease. Circulation 10, 2049-2053 (1999).
-
(1999)
Circulation
, vol.10
, pp. 2049-2053
-
-
Kong, D.F.1
Topol, E.J.2
Bittl, J.A.3
-
72
-
-
85030876429
-
Antibody against lepirudin are polyspecific and recognizes epitopes on bivalirudin
-
Eichler P, Lubenow N, Strobel U, Greinacher A. Antibody against lepirudin are polyspecific and recognizes epitopes on bivalirudin. Blood 103, 13-16 (2003).
-
(2003)
Blood
, vol.103
, pp. 13-16
-
-
Eichler, P.1
Lubenow, N.2
Strobel, U.3
Greinacher, A.4
-
73
-
-
0019891328
-
Potent inhibition of thrombin by the newly synthesized arginine derivative number 805. The importance of stereostructure of its hydrophobic carboxamide portion
-
Okamoto S, Hijikata A, Kikumoto R et al. Potent inhibition of thrombin by the newly synthesized arginine derivative number 805. The importance of stereostructure of its hydrophobic carboxamide portion. Biochem. Biophys. Res. Commun. 101, 440-446 (1981).
-
(1981)
Biochem. Biophys. Res. Commun.
, vol.101
, pp. 440-446
-
-
Okamoto, S.1
Hijikata, A.2
Kikumoto, R.3
-
74
-
-
0025155792
-
Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin III
-
Hijikata-Okunomiya A, Okamoto S Wanaka K. Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin III. Thromb. Res. 59, 967-977 (1990).
-
(1990)
Thromb. Res.
, vol.59
, pp. 967-977
-
-
Hijikata-Okunomiya, A.1
Okamoto, S.2
Wanaka, K.3
-
76
-
-
15144361588
-
Novastan (brand of argatroban): A small molecule, direct thrombin inhibitor
-
Hursting MJ, Alford KL, Becker JC et al. Novastan (brand of argatroban): a small molecule, direct thrombin inhibitor. Semin. Thromb. Hemost. 23, 503-516 (1997).
-
(1997)
Semin. Thromb. Hemost.
, vol.23
, pp. 503-516
-
-
Hursting, M.J.1
Alford, K.L.2
Becker, J.C.3
-
77
-
-
0032748914
-
Antithrombin agents: The new class of anticoagulant and antithrombotic drugs
-
Fareed J, Lewis BE, Callas DD et al. Antithrombin agents: the new class of anticoagulant and antithrombotic drugs. Clin. Appl. Thromb. Hemost. 5, S45-S55 (1999).
-
(1999)
Clin. Appl. Thromb. Hemost.
, vol.5
-
-
Fareed, J.1
Lewis, B.E.2
Callas, D.D.3
-
78
-
-
0035836541
-
Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia
-
Lewis BE, Wallis DE, Berkowitz SD et al. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 103, 1838-1843 (2001).
-
(2001)
Circulation
, vol.103
, pp. 1838-1843
-
-
Lewis, B.E.1
Wallis, D.E.2
Berkowitz, S.D.3
-
79
-
-
0035096023
-
Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia
-
Kondo LM, Wittkowsky AK, Wiggins BS. Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia. Ann. Pharmacother. 35, 440-451 (2001).
-
(2001)
Ann. Pharmacother.
, vol.35
, pp. 440-451
-
-
Kondo, L.M.1
Wittkowsky, A.K.2
Wiggins, B.S.3
-
80
-
-
0035251672
-
The direct thrombin inhibitor melagatran and its oral prodrug H376/95, intestinal absorption properties, biochemical and pharmacodynamic effect
-
Gustafsson D, Nyström JE, Carlsson S et al. The direct thrombin inhibitor melagatran and its oral prodrug H376/95, intestinal absorption properties, biochemical and pharmacodynamic effect. Thromb. Res. 101, 171-118 (2001).
-
(2001)
Thromb. Res.
, vol.101
, pp. 118-171
-
-
Gustafsson, D.1
Nyström, J.E.2
Carlsson, S.3
-
81
-
-
0037297332
-
Thrombin induced platelet activation and its inhibition by anticoagulants with different modes of action
-
Nylander S, Matsson C. Thrombin induced platelet activation and its inhibition by anticoagulants with different modes of action. Blood Coag. Fibrinol. 14, 1-9 (2003).
-
(2003)
Blood Coag. Fibrinol.
, vol.14
, pp. 1-9
-
-
Nylander, S.1
Matsson, C.2
-
82
-
-
0037454036
-
Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects
-
Sarich TC, Woltz M, Eriksson UG et al. Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects. J. Am. Coll. Cardiol. 41, 557-564 (2003).
-
(2003)
J. Am. Coll. Cardiol.
, vol.41
, pp. 557-564
-
-
Sarich, T.C.1
Woltz, M.2
Eriksson, U.G.3
-
83
-
-
0242365647
-
In vitro effect of melagatran and lepirudin on clot bound thrombin
-
Lebrazi J, Elalamy I, Samama MM. In vitro effect of melagatran and lepirudin on clot bound thrombin. Thromb. Res. 110, 249-252 (2003).
-
(2003)
Thromb. Res.
, vol.110
, pp. 249-252
-
-
Lebrazi, J.1
Elalamy, I.2
Samama, M.M.3
-
84
-
-
0031984477
-
Effects of melagatran, a new low-molecular-weight thrombin inhibitor on thrombin and fibrinolytic enzymes
-
Gustafsson D, Antonsson T, Bylund R et al. Effects of melagatran, a new low-molecular-weight thrombin inhibitor on thrombin and fibrinolytic enzymes. Thromb. Haemost. 79, 110-118 (1998).
-
(1998)
Thromb. Haemost.
, vol.79
, pp. 110-118
-
-
Gustafsson, D.1
Antonsson, T.2
Bylund, R.3
-
85
-
-
0013432360
-
Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects
-
Eriksson UG, Bredberg U, Gislén K et al. Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects. Eur. J. Clin. Pharmacol. 59(1), 35-43 (2003).
-
(2003)
Eur. J. Clin. Pharmacol.
, vol.59
, Issue.1
, pp. 35-43
-
-
Eriksson, U.G.1
Bredberg, U.2
Gislén, K.3
-
86
-
-
0033008172
-
Pharmacokinetics and pharmacodynamics of melagatran, a novel synthetic LMW thrombin inhibitor, in patients with acute DVT
-
Eriksson H, Eriksson U, Frison L et al. Pharmacokinetics and pharmacodynamics of melagatran, a novel synthetic LMW thrombin inhibitor, in patients with acute DVT. Thromb. Haemost. 81, 358-363 (1999).
-
(1999)
Thromb. Haemost.
, vol.81
, pp. 358-363
-
-
Eriksson, H.1
Eriksson, U.2
Frison, L.3
-
87
-
-
0036171348
-
A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran and its subcutaneous form, melagatran, compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I. MElagatran for THRombin inhibition in Orthopaedic surgery
-
Eriksson BI, Arfwidsson A-C, Frison L et al. A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran and its subcutaneous form, melagatran, compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I. MElagatran for THRombin inhibition in Orthopaedic surgery. Thromb. Haemost. 87, 231-237 (2002).
-
(2002)
Thromb. Haemost.
, vol.87
, pp. 231-237
-
-
Eriksson, B.I.1
Arfwidsson, A.-C.2
Frison, L.3
-
88
-
-
0030917536
-
A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent
-
Kelley RF, Refino CJ, O'Connell MP et al. A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent. Blood 89, 3219-3227 (1997).
-
(1997)
Blood
, vol.89
, pp. 3219-3227
-
-
Kelley, R.F.1
Refino, C.J.2
O'Connell, M.P.3
-
89
-
-
0029912586
-
Role of tissue factor and Factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon
-
Taylor FB Jr. Role of tissue factor and Factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon. Haemostasis 26, 83-91 (1996).
-
(1996)
Haemostasis
, vol.26
, pp. 83-91
-
-
Taylor Jr., F.B.1
-
90
-
-
0031404885
-
Oral delivery of heparin in combination with sodium N-(8-(2-dyfroxybenzoyl) amino) caproate: Pharmacological considerations
-
Rivera TM, Leone-Bay A, Paton DR et al. Oral delivery of heparin in combination with sodium N-(8-(2-dyfroxybenzoyl) amino) caproate: pharmacological considerations. Pharm. Res. 14, 1830-1834 (1997).
-
(1997)
Pharm. Res.
, vol.14
, pp. 1830-1834
-
-
Rivera, T.M.1
Leone-Bay, A.2
Paton, D.R.3
-
91
-
-
0031422605
-
Heparin absorption across the intestine: Effect of sodium N-(8-(2-dyfroxybenzoyl) amino) caproate in rat in situ intestinal instillations and Caco-2 monolayers
-
Brayden D, Creed E, O'Connell A et al. Heparin absorption across the intestine: effect of sodium N-(8-(2-dyfroxybenzoyl) amino) caproate in rat in situ intestinal instillations and Caco-2 monolayers. Pharm. Res. 14, 1772-1779 (1997).
-
(1997)
Pharm. Res.
, vol.14
, pp. 1772-1779
-
-
Brayden, D.1
Creed, E.2
O'Connell, A.3
-
92
-
-
0025789568
-
Active site-blocked Factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model
-
Benedict CR, Ryan J, Wolitzky B et al. Active site-blocked Factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model. Clin. Invest. 88, 1760-1765 (1991).
-
(1991)
Clin. Invest.
, vol.88
, pp. 1760-1765
-
-
Benedict, C.R.1
Ryan, J.2
Wolitzky, B.3
-
93
-
-
0025218438
-
Antithrombotic effect of recombinant human thrombomodulin on thrombin-induced thromboembolism in mice
-
Gomi K, Zushi M, Honda G et al. Antithrombotic effect of recombinant human thrombomodulin on thrombin-induced thromboembolism in mice. Blood 75, 1396-1399 (1990).
-
(1990)
Blood
, vol.75
, pp. 1396-1399
-
-
Gomi, K.1
Zushi, M.2
Honda, G.3
-
94
-
-
0032701594
-
An inhibitory anti-Factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis
-
Feuerstein GZ, Toomey JR, Valocik R et al. An inhibitory anti-Factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis. Thromb. Haemost. 82, 1443-1545 (1999).
-
(1999)
Thromb. Haemost.
, vol.82
, pp. 1443-1545
-
-
Feuerstein, G.Z.1
Toomey, J.R.2
Valocik, R.3
-
95
-
-
19244378454
-
Discovery and development of the novel potent orally-active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): Coapplication of structure-based design and rapid multiple analog synthesis on solid support
-
Brady SF, Stauffer KJ, Lumma WC et al. Discovery and development of the novel potent orally-active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analog synthesis on solid support. J. Med. Chem. 41, 401-406 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 401-406
-
-
Brady, S.F.1
Stauffer, K.J.2
Lumma, W.C.3
|