Selective inhibition of collagen gene expression in fibroblasts by an interferon-γ transgene

Experimental Lung Research

Volumn 25, Issue 3, 1999, Pages 199-215

  Jaffe, H Ari ^a,b   Gao, Zhancheng ^a   Mori, Yasuji ^a   Li, Liye ^a   Varga, John ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Adenovirus; Collagen; Fibroblast; Fibrosis; Interferon ; Transgene

Indexed keywords

COLLAGEN; COMPLEMENTARY DNA; GAMMA INTERFERON; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE REPAIR; TRANSGENE;

EID: 0032901003     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.1080/019021499270268     Document Type: Article

References (35)

1. 1. Silver RM: Interstitial lung disease of systemic sclerosis. Int Rev Immunol. 1995;12:281-291.
2. 2. Bienkowski RS, Gotkin MG: Control of collagen deposition in mammalian lung. Proc Soc Exp Biol Med. 1995;209:118-140.
3. 3. Varga J, Jimenez SA: Modulation of collagen gene expression: its relation to fibrosis in systemic sclerosis and other disorders. Ann Intern Med. 1995;122:60-62.
4. 4. Dean DC, Newby RF, Bourgeois S: Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines. J Cell Biol. 1988;106:2159-2170.
5. 5. Jimenez SA, Varga J, Olsen A, Li L, Diaz A, Herhal J, Koch J: Functional analysis of human α 1(1) procollagen gene promoter. Differential activity in collagen-producing and -nonproducing cells and response to transforming growth factor β1. J Biol Chem. 1994;269:12684-12691.
6. 6. Broekelmann TJ, Limper AH, Colby TV, McDonald JA: Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA. 1991;88:6642-6646.
7. 7. Corrin B, Butcher D, McAnulty BJ, Dubois RM, Black CM, Laurent GJ, Harrison NK: Immunohistochemical localization of transforming growth factor-beta 1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders. Histopathology. 1994;24:145-150.
8. 8. Raghow B, Irish P, Kang AH: Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis. J Clin Invest. 1989;84:1836-1842.
9. 9. Yi ES, Bedoya A, Lee H, Chin E, Saunders W, Kim SJ, Danielpour D, Remick DG, Yin S, Ulich TR: Radiation-induced lung injury in vivo: expression of transforming growth factor-beta precedes fibrosis. Inflammation. 1996;20:339-352.
10. 10. Billiau A: Interferon-gamma: biology and role in pathogenesis. Adv Immunol. 1996;62:61-130.
11. 11. Jimenez SA, Freundlich B, Rosenbloom J: Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest. 1984;74:1112-1116.
12. 12. Narayanan AS, Whithey J, Souza A, Raghu G: Effect of gamma-interferon on collagen synthesis by normal and fibrotic human lung fibroblasts. Chest. 1992;101:1326-1331.
13. 13. Kahari VM, Chen YQ, Su MW, Ramirez F, Uitto J: Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and post-transcriptional levels. J Clin Invest. 1990;86:1489-1495.
14. 14. Diaz A, Jimenez SA: Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms. Int J Biochem Cell Biol. 1997;29:251-260.
15. 15. Varga J, Olsen A, Herhal J, Constantine G, Rosenbloom J, Jimenez SA: Interferon-gamma reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor-beta in normal human fibroblasts. Eur J Clin Invest. 1990;20:487-493.
16. 16. Gurujeyalakshmi G, Giri SN: Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin - mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression. Exp Lung Res. 1995;21:791-808.
17. 17. Bolinger AM, Taeubel MA: Recombinant interferon gamma for treatment of chronic granulomatous disease and other disorders. Clin Pharm. 1992;11:834-850.
18. 18. Varga J: Recombinant cytokine treatment for scleroderma. Can the antifibrotic potential of interferon-gamma be realized clinically? Arch Dermatol. 1997; 133:637-642.
19. 19. Jaffe HA, Buhl R, Mastrangeli A, Holroyd KJ, Saltini C, Czerski D, Jaffe HS, Kramer S, Sherwin S, Crystal RG: Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-gamma to the human lung. J Clin Invest 1991;88:297-302.
20. 20. Crystal RG, McElvaney NG, Rosenfeld MA, Chu CS, Mastrangeli A, Hay JG, Brody SL, Jaffe HA, Eissa NT, Danel C: Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nature Genet. 1994;8:42-51.
21. 21. Wilson JM: Adenoviruses as gene-delivery vehicles. N Engl J Med. 1996;334:1185-1187.
22. 22. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
23. 23. Graham FL, Smiley J, Russell WC, Nairn R: Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol. 1977;36:59-74.
24. 24. McGrory WJ, Bautista DS, Graham FL: A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology. 1988;163:614-617.
25. 25. Jaffe HA, Danel C, Longenecker G, Metzger M, Setoguchi Y, Rosenfeld MA, Gant TW, Thorgeirsson SS, Stratford-Perricaudet LD, Perricaudet M, et al.: Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nature Genet 1992;1:372-378.
26. 26. Lemarchand P, Jaffe HA, Danel C, Cid MC, Kleinman HK, Stratford-Perricaudet LD, Perricaudet M, Pavirani A, Lecocq JP, Crystal RG: Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells. Proc Natl Acad Sci USA. 1992,89:6482-6486.
27. 27. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
28. 28. Varga J, Jimenez SA: Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-β. Biochem Biophys Res Commun. 1986;138:974-980.
29. 29. Vanguri P, Farber JM: Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. J Biol Chem. 1990;265:15049-15057.
30. 30. Prior C, Haslam PL: Increased levels of serum interferon-gamma in pulmonary sarcoidosis and relationship with response to corticosteroid therapy. Am Rev Respir Dis. 1991;143:53-60.
31. 31. Prior C, Haslam PL: In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases. Clin Exp Immunol. 1992;88:280-287.
32. 32. Kuroki S, Ohta A, Sueoka N, Katoh O, Yamada H, Yamaguchi M: Determination of various cytokines and type III procollagen aminopeptide levels in bronchoalveolar lavage fluid of the patients with pulmonary fibrosis: inverse correlation between type III procollagen aminopeptide and interferon-gamma in progressive patients. Br J Rheumatol. 1995;34:31-36.
33. 33. Okada T, Sugie I, Aisaka K: Effects of γ-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats. Lymphokine Cytokine Res. 1993;12:87-91.
34. 34. Ilan Y, Prakash R, Davidson A, Jona V, Droguett G, Horwitz MS, Chowdhury NR, Chowdhury JR: Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors. J Clin Invest 1997;99:1098-1106.
35. 35. Yang Y, Trinchieri G, Wilson JM: Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1995;1:890-893.