Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice

Experimental Cell Research

Volumn 314, Issue 6, 2008, Pages 1202-1216

  Deutsch, Urban ^a   Schlaeger, Thorsten M ^b   Dehouck, Bénédicte ^b   Döring, Axinia ^a   Tauber, Silke ^b   Risau, Werner ^b   Engelhardt, Britta ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Activator; Endothelium; MAdCAM 1; Responder; TET OFF; TET ON; Tetracycline regulated gene expression; Tie 2 promoter

Indexed keywords

ANGIOPOIETIN RECEPTOR; BETA GALACTOSIDASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; EMBRYO; ENDOTHELIUM CELL; GENE CONSTRUCT; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REPRESSOR GENE; TRANSACTIVATION; TRANSGENE; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

EID: 40049098305     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.12.026     Document Type: Article

References (48)

1. N.W. Gale G.D. Yancopoulos Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development Genes Dev. 13 1999 1055 1066
2. G.D. Yancopoulos S. Davis N.W. Gale J.S. Rudge S.J. Wiegand J. Holash Vascular-specific growth factors and blood vessel formation Nature 407 2000 242 248
3. J. Rossant L. Howard Signaling pathways in vascular development Annu. Rev. Cell Dev. Biol. 18 2002 541 573
4. M. Lewandoski Conditional control of gene expression in the mouse Nat. Rev., Genet. 2 2001 743 755
5. Y. Furuta R.R. Behringer Recent innovations in tissue-specific gene modifications in the mouse Birth Defects Res. C Embryo Today 75 2005 43 57
6. J.A. Alva A.C. Zovein A. Monvoisin T. Murphy A. Salazar N.L. Harvey P. Carmeliet M.L. Iruela-Arispe VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells Dev. Dyn. 235 2006 759 767
7. A. Monvoisin J.A. Alva J.J. Hofmann A.C. Zovein T.F. Lane M.L. Iruela-Arispe VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium Dev. Dyn. 235 2006 3413 3422
8. D. No T.P. Yao R.M. Evans Ecdysone-inducible gene expression in mammalian cells and transgenic mice, Proceedings of the National Academy of Sciences of the United States of America 93 1996 3346 3351
9. C.A. Cronin W. Gluba H. Scrable The lac operator-repressor system is functional in the mouse Genes Dev. 15 2001 1506 1517
10. P.A. Furth L. St Onge H. Boger P. Gruss M. Gossen A. Kistner H. Bujard L. Hennighausen Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter Proc. Natl. Acad. Sci. U. S. A. 91 1994 9302 9306
11. A. Kistner M. Gossen F. Zimmermann J. Jerecic C. Ullmer H. Lubbert H. Bujard Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice Proc. Natl. Acad. Sci. U. S. A. 93 1996 10933 10938
12. U. Baron H. Bujard Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances Methods Enzymol. 327 2000 401 421
13. K. Iljin T.V. Petrova T. Veikkola V. Kumar M. Poutanen K. Alitalo A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos FASEB J. 16 2002 1764 1774
14. C. Kremer G. Breier W. Risau K.H. Plate Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system Cancer Res. 57 1997 3852 3859
15. P.J. Cowan D. Tsang C.M. Pedic L.R. Abbott T.A. Shinkel A.J. d'Apice M.J. Pearse The human ICAM-2 promoter is endothelial cell-specific in vitro and in vivo and contains critical Sp1 and GATA binding sites J. Biol. Chem. 273 1998 11737 11744
16. P.J. Cowan T.A. Shinkel N. Fisicaro J.W. Godwin C. Bernabeu N. Almendro C. Rius A.J. Lonie M.B. Nottle P.L. Wigley K. Paizis M.J. Pearse A.J. D'Apice Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters, Xenotransplantation 10 2003 223 231
17. S. Gory M. Vernet M. Laurent E. Dejana J. Dalmon P. Huber The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice Blood 93 1999 184 192
18. T.M. Schlaeger S. Bartunkova J.A. Lawitts G. Teichmann W. Risau U. Deutsch T.N. Sato Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice Proc. Natl. Acad. Sci. U. S. A. 94 1997 3058 3063
19. A. Döring M. Wild D. Vestweber U. Deutsch B. Engelhardt E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice J. Immunol. 179 2007 8470 8479
20. J.H. Chung A.C. Bell G. Felsenfeld Characterization of the chicken beta-globin insulator Proc. Natl. Acad. Sci. U. S. A. 94 1997 575 580
21. M.J. Briskin L.M. McEvoy E.C. Butcher MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1 Nature 363 1993 461 464
22. S.T. Jalkanen R.F. Bargatze L.R. Herron E.C. Butcher A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man Eur. J. Immunol. 16 1986 1195 1202
23. R. Bosse D. Vestweber Only simultaneous blocking of the L- and P-selectin completely inhibits neutrophil migration into mouse peritoneum Eur. J. Immunol. 24 1994 3019 3024
24. M. Hammel G. Weitz-Schmidt A. Krause T. Moll D. Vestweber H.G. Zerwes R. Hallmann Species-specific and conserved epitopes on mouse and human E-selectin important for leukocyte adhesion Exp. Cell Res. 269 2001 266 274
25. C. Albanese J. Hulit T. Sakamaki R.G. Pestell Recent advances in inducible expression in transgenic mice Semin. Cell Dev. Biol. 13 2002 129 141
26. E. Bockamp M. Maringer C. Spangenberg S. Fees S. Fraser L. Eshkind F. Oesch B. Zabel Of mice and models: improved animal models for biomedical research Physiol. Genomics 11 2002 115 132
27. M. Gossen H. Bujard Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc. Natl. Acad. Sci. U. S. A. 89 1992 5547 5551
28. M. Gossen S. Freundlieb G. Bender G. Muller W. Hillen H. Bujard Transcriptional activation by tetracyclines in mammalian cells Science 268 1995 1766 1769
29. U. Baron M. Gossen H. Bujard Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential Nucleic Acids Res. 25 1997 2723 2729
30. S. Urlinger U. Baron M. Thellmann M.T. Hasan H. Bujard W. Hillen Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity Proc. Natl. Acad. Sci. U. S. A. 97 2000 7963 7968
31. T.M. Schlaeger Y. Qin Y. Fujiwara J. Magram T.N. Sato Vascular endothelial cell lineage-specific promoter in transgenic mice Development 121 1995 1089 1098
32. M. Yano A. Iwama H. Nishio J. Suda G. Takada T. Suda Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells Blood 89 1997 4317 4326
33. I. Hamaguchi X.L. Huang N. Takakura J. Tada Y. Yamaguchi H. Kodama T. Suda In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region Blood 93 1999 1549 1556
34. J. Chen M.B. Kelz G. Zeng N. Sakai C. Steffen P.E. Shockett M.R. Picciotto R.S. Duman E.J. Nestler Transgenic animals with inducible, targeted gene expression in brain Mol. Pharmacol. 54 1998 495 503
35. A.C. Bell A.G. West G. Felsenfeld Insulators and boundaries: versatile regulatory elements in the eukaryotic Science 291 2001 447 450
36. F. Recillas-Targa V. Valadez-Graham C.M. Farrell Prospects and implications of using chromatin insulators in gene therapy and transgenesis BioEssays 26 2004 796 807
37. M. Gaszner G. Felsenfeld Insulators: exploiting transcriptional and epigenetic mechanisms Nat. Rev., Genet. 7 2006 703 713
38. Z. Qu J.V. Thottassery S. Van Ginkel M. Manuvakhova L. Westbrook C. Roland-Lazenby S. Hays F.G. Kern Homogeneity and long-term stability of tetracycline-regulated gene expression with low basal activity by using the rtTA2S-M2 transactivator and insulator-flanked reporter vectors Gene 327 2004 61 73
39. B. Engelhardt D. Vestweber R. Hallmann M. Schulz E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis Blood 90 1997 4459 4472
40. B.J. Steffen E.C. Butcher B. Engelhardt Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse Am. J. Pathol. 145 1994 189 201
41. R. Sarao D.J. Dumont Conditional transgene expression in endothelial cells Transgenic Res. 7 1998 421 427
42. H. Boger P. Gruss Functional determinants for the tetracycline-dependent transactivator tTA in transgenic mouse embryos Mech. Dev. 83 1999 141 153
43. P.I. Teng M.R. Dichiara L.G. Komuves K. Abe T. Quertermous J.N. Topper Inducible and selective transgene expression in murine vascular endothelium Physiol. Genomics 11 2002 99 107
44. H.S. Radomska D.A. Gonzalez Y. Okuno H. Iwasaki A. Nagy K. Akashi D.G. Tenen C.S. Huettner Transgenic targeting with regulatory elements of the human CD34 gene Blood 100 2002 4410 4419
45. J.F. Sun T. Phung I. Shiojima T. Felske J.N. Upalakalin D. Feng T. Kornaga T. Dor A.M. Dvorak K. Walsh L.E. Benjamin Microvascular patterning is controlled by fine-tuning the Akt signal Proc. Natl. Acad. Sci. U. S. A. 102 2005 128 133
46. T.R. Carlson Y. Yan X. Wu M.T. Lam G.L. Tang L.J. Beverly L.M. Messina A.J. Capobianco Z. Werb R. Wang Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice Proc. Natl. Acad. Sci. U. S. A. 102 2005 9884 9889
47. H. Hisatsune K. Matsumura M. Ogawa A. Uemura N. Kondo J.K. Yamashita H. Katsuta S. Nishikawa T. Chiba S. Nishikawa High level of endothelial cell-specific gene expression by a combination of the 5′ flanking region and the 5′ half of the first intron of the VE-cadherin gene Blood 105 2005 4657 4663
48. R.M. Porat M. Grunewald A. Globerman A. Itin G. Barshtein L. Alhonen K. Alitalo E. Keshet Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies Circ. Res. 94 2004 394 401