Functional determinants for the tetracycline-dependent transactivator tTA in transgenic mouse embryos

Mechanisms of Development

Volumn 83, Issue 1-2, 1999, Pages 141-153

  Boger, Hinrich ^a   Gruss, Peter ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Activated transcription; Alkaline phosphatase; Butyrate; Gene trap; Histone acetylation; Mouse development; Promoter preactivation; TetR VP16; Transgene; TSA; tTA

Indexed keywords

TETRACYCLINE; TRANSACTIVATOR PROTEIN;

ACETYLATION; ANIMAL TISSUE; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE FUNCTION; HISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; TRANSGENE;

ABDOMEN; ACETYLATION; ANIMALS; ANTIBIOTICS, ANTIFUNGAL; BETA-GALACTOSIDASE; BUTYRATES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; EPIDERMIS; HISTONES; HYDROXAMIC ACIDS; MICE; MICE, TRANSGENIC; MODELS, GENETIC; PROMOTER REGIONS (GENETICS); TETRACYCLINE; TIME FACTORS; TRANS-ACTIVATORS;

ANIMALIA; MUS MUSCULUS;

EID: 0033042685     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(99)00042-8     Document Type: Article

References (44)

1. Akimura H., Chen Y., Dai P., Hou D.X., Nonaka M., Smolik S.M., Armstrong S., Goodman R.H., Ishii S. Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature. 386:1997;735-738.
2. Baron U., Gossen M., Bujard H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 25:1997;2723-2729.
3. Berger S.L., Cress W.D., Cress A., Triezenberg S.I., Guarente L. Selective inhibition of activated but not basal transcription by the acidic domain of VP16: evidence for transcriptional adaptors. Cell. 61:1990;1199-1208.
4. Blanco J.C.G., Minucci S., Lu J., Yang X.J., Walker K.K., Chen H., Evans R. M., Nakatani, Y., Ozato, K., The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev. 12:1998;1638-1651.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Candido E.P.M., Reeves R., Davie J.R. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell. 14:1978;105-113.
7. Chakravati D., LaMorte V.J., Nelson M.C., Nakajima T., Schulman I.G., Juguilon H., Montminy M., Evans R.M. Role of CBP/P300 in nuclear receptor signalling. Nature. 383:1996;99-103.
8. Efrat S., Fusco-DeMane D., Lemberg H., Emran O.A., Wang X. Conditional transformation of a pancreatic β-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc. Natl. Acad. Sci. USA. 92:1995;3576-3580.
9. Ewald D., Li M., Efrat S., Auer G., Wall R.J., Furth P.A., Henninghausen L. Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. Science. 273:1996;1384-1386.
10. Felsenfeld G. Chromatin unfolds. Cell. 86:1996;13-19.
11. Friedrich G., Soriano P. Promotor traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5:1991;1513-1523.
12. Fryer C.J., Archer T.K. Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nature. 393:1998;88-91.
13. Furth P., St. Onge L., Böger H., Gruss P., Gossen M., Kistner A., Bujard H., Henninghausen L. Temporal control of gene expression in transgenic mice by a tetracyclin-responsive promoter. Proc. Natl. Acad. Sci. USA. 91:1994;9302-9306.
14. Gallia G., Khalili K. Evaluation of an autoregulatory tetracycline regulated system. Oncogene. 16:1998;1879-1884.
15. Georgakopoulos T., Thireos G. Two distinct yeast transcriptional activators require the function of GCNS protein to promote normal levels of transcription. EMBO J. 11:1992;4145-4152.
16. Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracyclin-responsive promoters. Proc. Natl. Acad. Sci. USA. 89:1992;5547-5551.
17. Greogory P.D., Schmid A., Zavari M., Lui L., Berger S.L., Hörz W. Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHOS promoter in yeast. Mol. Cell. 1:1998;495-505.
18. Gu W., Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the C-terminal domain. Cell. 90:1997;595-606.
19. Hillen W., Gatz C., Altschmied L., Schollmeier K., Meier I. Control of expression of the Tn10-encoded tetracycline resistance genes. J. Mol. Biol. 169:1983;707-721.
20. Hogan B., Beddington R., Constantini F., Lacy E. Manipulating the Mouse Embryo. 1994;Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY.
21. Jackson R.J., Howell M.T., Kaminski A. The novel mechanism of initiation of picornavirus RNA translation. Trends Biochem. Sci. 15:1990;477-483.
22. Kamei Y., Xu L., Heinzel T., Torchia J., Kurokawa R., Gloss B., Lin S.C., Heyman R.A., Rose D.W., Glass C.K., Rosenfeld M.G. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 85:1996;403-414.
23. Kaminski A., Howell M.T., Jackson R.J. Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism. EMBO J. 9:1990;3753-3759.
24. Kleinschmidt C., Tovar K., Hillen W., Porschke D. Dynamics of repressor-operator recognition: The Tn10-encoded tetracycline resistance control. Biochemistry. 27:1988;1094-1104.
25. Kraus W.L., Kadonaga J.T. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation. Genes Dev. 12:1997;331-342.
26. Kwon H., Imbalzano A.N., Khavari P.A., Kingston R.E., Green M. Nucleosome disruption and enhancement of activator binding by a human SWI/SNF complex. Nature. 370:1994;477-481.
27. Lee D.Y., Hayes J.J., Pruss D., Wolffe A.P. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell. 72:1993;73-84.
28. Mayford M., Bach M.E., Huang Y.Y., Wang L., Hawkins R.D., Kandel E.R. Control of memory formation through regulated expression of a CaMKII transgene. Science. 274:1996;1678-1683.
29. Müller G., Hecht B., Helbl V., Hinrichs W., Saenger W., Hillen W. Characterization of non-inducible Tet repressor mutants suggests conformational changes necessary for induction. Nature Struc. Biol. 2:1995;693-702.
30. Munshi N., Merika M., Yie J., Senger K., Chen G., Thanos D. Acetylation of HMG 1(Y) by CBP turns off IFNβ expression by disrupting the enhanceosome. Mol. Cell. 2:1998;457-467.
31. Nagy A., Rossant J., Nagy R., Abramow-Newerly W., Roder J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA. 90:1993;8424-8428.
32. Pikaart M.J., Recillas-Targa F., Felsenfeld G. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev. 12:1998;2852-2862.
33. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Sealy L., Chalkley R. The effect of sodium butyrate on histone modification. Cell. 14:1978;115-121.
35. Taylor I.C.A., Workman I.L., Schuetz T.J., Kingston R.E. Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains. Genes Dev. 5:1991;1285-1298.
36. Torres M., Mansouri A. Celis J.E. Gene Targeting by Homologous Recombination in Embryonic Stem Cells. 1994;112 Academic Press, Cambridge.
37. Vettese-Dadey M., Grant P.A., Hebbes T.R., Crane-Robinson C., Allis C.D., Workman J.L. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J. 15:1996;2508-2518.
38. Walters M.C., Fiering S., Eidemiller J., Magis W., Groudine M., Martin D.I.K. Enhancers increase the probability but not the level of gene expression. Proc. Natl. Acad. Sci. USA. 92:1995;7125-7129.
39. Weintraub H. Formation of stable transcription complexes as assayed by analysis of individual templates. Proc. Natl. Acad. Sci. USA. 85:1988;5819-5823.
40. Wilson C., Bellen H.J., Gehring W.J. Position effects on eukaryotic gene expression. Annu. Rev. Cell Biol. 6:1990;679-714.
41. Yoshida M., Horinuchi S., Beppu T. Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays. 17:1995;423-430.
42. Yuan W., Condorelli G., Caruso G., Felsani A., Giordano A. Human p300 protein is a coactivator for the transcription factor MyoD. J. Biol. Chem. 271:1996;9009-9013.
43. Zhong H., Voll R.E., Ghosh S. Phosphorylation of NF-kB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell. 1:1998;661-671.
44. Zlokarnik G., Negulescu P.A., Knapp T.E., Mere L., Burres N., Feng L., Whiney M., Roemer K., Tsien R.Y. Quantitation of transcription and clonal selection of single living cells with β-lactamase as reporter. Science. 279:1998;84-88.