PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy

Free Radical Biology and Medicine

Volumn 44, Issue 6, 2008, Pages 972-981

  Obrosova, Irina G ^a   Xu, Weizheng ^b   Lyzogubov, Valeriy V ^a   Ilnytska, Olga ^a   Mashtalir, Nazar ^a   Vareniuk, Igor ^a   Pavlov, Ivan A ^a   Zhang, Jie ^b   Slusher, Barbara ^b   Drel, Viktor R ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b MGI Pharma   (United States)

Author keywords

Free radicals; Intraepidermal nerve fiber loss; Mechanical hyperalgesia; Mechanical hypoalgesia; Neuropathic pain; Oxidative nitrosative stress; Poly(ADP ribose) polymerase; Tactile allodynia; Thermal hypoalgesia

Indexed keywords

10 (4 METHYLPIPERAZIN 1 YLMETHYL) 2H 7 OXA 1,2 DIAZA BENZO[DE]ANTHRACEN 3 ONE; FORMALDEHYDE; GPI 15427; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC DISORDER; HYPERALGESIA; HYPOALGESIA; MALE; MOUSE; NERVE FIBER DEGENERATION; NEUROPATHIC PAIN; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PAIN ASSESSMENT; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TREATMENT DURATION; TREATMENT RESPONSE;

MUS; RATTUS;

EID: 39849088155     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.09.013     Document Type: Article

References (43)

1. P. Jagtap C. Szabo Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors Nat. Rev. Drug Discovery 4 2005 421 440
2. F. Garcia Soriano L. Virag P. Jagtap E. Szabo J.G. Mabley L. Liaudet A. Marton D.G. Hoyt K.G. Murthy A.L. Salzman G.J. Southan C. Szabo Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation Nat. Med. 7 2001 108 113
3. P. Pacher L. Liaudet F.G. Soriano J.G. Mabley E. Szabo C. Szabo The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes Diabetes 51 2002 514 521
4. I.G. Obrosova F. Li O.I. Abatan M.A. Forsell K. Komjati P. Pacher C. Szabo M.J. Stevens Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy Diabetes 53 2004 711 720
5. F. Li C. Szabo P. Pacher G.J. Southan O.I. Abatan T. Charniauskaya M.J. Stevens I.G. Obrosova Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy Diabetologia 47 2004 710 717
6. T.M. Gibson M.A. Cotter N.E. Cameron Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats Nitric Oxide 15 2006 344 350
7. L. Zheng C. Szabo T.S. Kern Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB Diabetes 53 2004 2960 2967
8. I.G. Obrosova A.G. Minchenko R.N. Frank G.M. Seigel Z. Zsengeller P. Pacher M.J. Stevens C. Szabo Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression Int. J. Mol. Med. 14 2004 55 64
9. A.G. Minchenko M.J. Stevens L. White O.I. Abatan K. Komjati P. Pacher C. Szabo I.G. Obrosova Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation FASEB J. 17 2003 1514 1516
10. C. Szabo A. Biser R. Benko E. Bottinger K. Susztak Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice Diabetes 55 2006 3004 3012
11. A.K. Cheung M.K. Fung A.C. Lo T.T. Lam K.F. So S.S. Chung S.K. Chung Aldose reductase deficiency prevents diabetes-induced blood–retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice Diabetes 54 2005 3119 3125
12. V.R. Drel N. Mashtalir O. Ilnytska J. Shin F. Li V.V. Lyzogubov I.G. Obrosova The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity Diabetes 55 2006 3335 3343
13. C. Szabo A. Zanchi K. Komjati P. Pacher A.S. Krolewski W.C. Quist F.W. LoGerfo E.S. Horton A. Veves Poly(ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity Circulation 106 2002 2680 2686
14. I.G. Obrosova O. Ilnytska V.V. Lyzogubov N. Mashtalir J.L. Nadler V.R. Drel High fat diet-induced neuropathy of prediabetes and obesity: effects of “healthy” diet and aldose reductase inhibition (abstract) Diabetes 56 2007 2598 2608
15. H.C. Ha L.D. Hester S.H. Snyder Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia Proc. Natl. Acad. Sci. U. S. A. 99 2002 3270 3275
16. T. Genovese E. Mazzon R. Di Paola C. Muia M.D. Threadgill A.P. Caputi C. Thiemermann S. Cuzzocrea Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury J. Pharmacol. Exp. Ther. 313 2005 529 538
17. M. Rajesh P. Mukhopadhyay S. Batkai G. Godlewski G. Hasko L. Liaudet P. Pacher Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis Biochem. Biophys. Res. Commun. 350 2006 352 357
18. S.W. Yu H. Wang M.F. Poitras C. Coombs W.J. Bowers H.J. Federoff G.G. Poirier T.M. Dawson V.L. Dawson Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor Science 297 2002 259 263
19. S.A. Andrabi N.S. Kim S.W. Yu H. Wang D.W. Koh M. Sasaki J.A. Klaus T. Otsuka Z. Zhang R.C. Koehler P.D. Hurn G.G. Poirier V.L. Dawson T.M. Dawson Poly(ADP-ribose) (PAR) polymer is a death signal Proc. Natl. Acad. Sci. U. S. A. 103 2006 18308 18313
20. O. Ilnytska V.V. Lyzogubov M.J. Stevens V.R. Drel N. Mashtalir P. Pacher M.A. Yorek I.G. Obrosova Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy Diabetes 55 2006 1686 1694
21. L. Tentori C. Leonetti M. Scarsella A. Muzi E. Mazzon M. Vergati O. Forini R. Lapidus W. Xu A.S. Dorio J. Zhang S. Cuzzocrea G. Graziani Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma FASEB J. 20 2006 1709 1711
22. R. Di Paola E. Mazzon W. Xu T. Genovese D. Ferrraris C. Muia C. Crisafulli J. Zhang S. Cuzzocrea Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock Eur. J. Pharmacol. 527 2005 163 171
23. A.A. Pieper D.J. Brat D.K. Krug C.C. Watkins A. Gupta S. Blackshaw A. Verma Z.Q. Wang S.H. Snyder Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes Proc. Natl. Acad. Sci. U. S. A. 96 1999 3059 3064
24. J.G. Mabley W.L. Suarez-Pinzon G. Hasko A.L. Salzman A. Rabinovitch E. Kun C. Szabo Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes Br. J. Pharmacol. 133 2001 909 919
25. A.J. Boulton R.A. Malik J.C. Arezzo J.M. Sosenko Diabetic somatic neuropathies Diabetes Care 27 2004 1458 1486
26. A. Pertovaara H. Wei J. Kalmari M. Ruotsalainen Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: modulation by nitecapone, a COMT inhibitor with antioxidant properties Exp. Neurol. 167 2001 425 434
27. N.E. Cameron A.M. Jack M.A. Cotter Effect of α-lipoic acid on vascular responses and nociception in diabetic rats Free Radic. Biol. Med. 31 2001 125 135
28. N.E. Cameron Z. Tuck L. McCabe M.A. Cotter Effect of the hydroxyl radical scavenger, dimethylthiourea, on peripheral nerve tissue perfusion, conduction velocity and nociception in experimental diabetes Diabetologia 44 2001 1161 1169
29. I.G. Obrosova J.G. Mabley Z. Zsengeller T. Charniauskaya O.I. Abatan J.T. Groves C. Szabo Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst FASEB J. 19 2005 401 403
30. I. Vareniuk I.A. Pavlov V.R. Drel V.V. Lyzogubov O. Ilnytska S.R. Bell J. Tibrewala J.T. Groves I.G. Obrosova Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice Exp. Neurol. 205 2007 425 436
31. V.R. Drel P. Pacher I. Vareniuk I. Pavlov O. Ilnytska V.V. Lyzogubov J. Tibrewala J.T. Groves I.G. Obrosova A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice Eur. J. Pharmacol. 569 2007 48 58
32. P. Pacher C. Szabo Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme Antioxid. Redox Signal. 7 2005 1568 1580
33. P. Pacher C. Szabo Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes Curr. Opin. Pharmacol. 6 2006 136 141
34. P. Pacher J.S. Beckman L. Liaudet Nitric oxide and peroxynitrite in health and disease Physiol. Rev. 87 2007 315 424
35. P.J. Dyck P.J. Dyck T.S. Larson P.C. O'Brien J.A. Velosa Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve Growth Factor Study Group Diabetes Care 23 2000 510 517
36. N.A. Calcutt J.D. Freshwater A.P. Mizisin Prevention of sensory disorders in diabetic Sprague–Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor Diabetologia 47 2004 718 724
37. F. Li I.G. Obrosova O. Abatan D. Tian D. Larkin E.L. Stuenkel M.J. Stevens Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats Am. J. Physiol: Endocrinol. Metab. 288 2005 E29 E36
38. J.A. Christianson J.T. Riekhof D.E. Wright Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice Exp. Neurol. 179 2003 188 199
39. A.I. Vinik S. Suwanwalaikorn K.B. Stansberry M.T. Holland P.M. McNitt L.E. Colen Quantitative measurement of cutaneous perception in diabetic neuropathy Muscle Nerve 18 1995 574 584
40. C.J. Sumner S. Sheth J.W. Griffin D.R. Cornblath M. Polydefkis The spectrum of neuropathy in diabetes and impaired glucose tolerance Neurology 60 2003 108 111
41. C. Toth V. Brussee D.W. Zochodne Remote neurotrophic support of epidermal nerve fibres in experimental diabetes Diabetologia 49 2006 1081 1088
42. J.A. Christianson J.M. Ryals M.S. Johnson R.T. Dobrowsky D.E. Wright Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice Neuroscience 145 2007 303 313
43. G. Pittenger N. Burkus P. McNulty B. Basta A. Vinik Intraepidermal nerve fibers are indicators of small fiber neuropathy in both diabetic and non-diabetic patients Diabetes Care 27 2004 1974 1979