Effect of α-lipoic acid on vascular responses and nociception in diabetic rats

Free Radical Biology and Medicine

Volumn 31, Issue 1, 2001, Pages 125-135

  Cameron, Norman E ^a,b   Jack, Alison M ^a   Cotter, Mary A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Autonomic nervous system; Blood flow; Diabetes mellitus; EDHF; Free radicals; Mesenteric vasculature; Neuropathy; Nitric oxide; Oxidative stress; Pain; Vascular endothelium

Indexed keywords

ACETYLCHOLINE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; METAL CHELATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; SCAVENGER; STREPTOZOCIN; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG EFFECT; HYPERALGESIA; IN VITRO STUDY; MALE; MECHANICAL STIMULATION; MESENTERY BLOOD VESSEL; NERVE FIBER C; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; OXIDATIVE STRESS; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; SUPERIOR CERVICAL GANGLION; THERMAL STIMULATION; TREATMENT OUTCOME; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; ANTIOXIDANTS; BLOOD FLOW VELOCITY; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; MALE; MESENTERIC ARTERIES; MUSCLE, SMOOTH, VASCULAR; PAIN; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SUPERIOR CERVICAL GANGLION; THIOCTIC ACID; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 0035399658     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00564-0     Document Type: Article

References (73)

1. The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications
2. Vascular factors in diabetic neuropathy
3. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats
4. Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-diabetic rats
5. Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta
6. Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway
7. Impairment of endothelium-dependent dilation of the basilar artery during diabetes mellitus
8. Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle
9. Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy
10. Effects of diabetes on reactivity of sciatic vasa nervorum in rats
11. Endothelial dysfunction in the perfused kidney from the streptozotocin-induced diabetic rat
12. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: Influence of tocopherol as antioxidant
13. Alterations in endothelium-dependent hyperpolarization and relaxation of mesenteric arteries from streptozotocin-induced diabetic rats
14. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
15. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
16. Regional differences in endothelium-dependent relaxation in the rat: Contribution of nitric oxide and nitric oxide-independent mechanisms
17. The alternative: EDHF
18. Hyperpolarizing factors
19. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
20. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
21. Contraction and relaxation of aortas from diabetic rats: Effects of chronic anti-oxidant and aminoguanidine treatments
22. Diabetes-induced endothelial dysfunction is prevented by long-term treatment with the modified iron chelator, hydroxyethyl starch conjugated-deferoxamine
23. Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin rat
24. Alpha-lipoic acid as a biological antioxidant
25. Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy
26. Effects of α-lipoic acid on neurovascular function in diabetic rats: Interaction with essential fatty acids
27. Effect of diabetes and treatment with the antioxidant, α-lipoic acid, on endothelial and neurogenic responses of corpus cavernosum in rats
28. Neuropathology and blood flow of nerve, spinal roots and dorsal root ganglia in longstanding diabetic rats
29. Effects of aldose reductase inhibition on responses of the corpus cavernosum and mesenteric vascular bed of diabetic rats
30. Nerve blood flow in early experimental diabetes in rats: Relation to conduction deficits
31. 2 clearance curves used to measure blood flow in rat sciatic nerve
32. A method for measurement of analgesic activity on inflamed tissue
33. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
34. Mechanisms underlying the attenuation of endothelium-dependent vasodilatation in the mesenteric arterial bed of the streptozotocin-induced diabetic rat
35. Fosinopril improves regulation of vascular tone in mesenteric bed of diabetic rats
36. Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats
37. Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats
38. Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats
39. Histamine relaxation of aortic rings from diabetic rats
40. Oxidative stress and Na/K ATPase activity in diabetic rats: Aldose reductase inhibitor withdrawal studies
41. Cytochrome P450 2C is an EDHF synthase in coronary arteries
42. An endogenous cannabinoid as an endothelium-derived vasorelaxant
43. + is an endothelium-derived hyperpolarizing factor in rat arteries
44. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries
45. Responses of the isolated perfused mesenteric vasculature from diabetic rats: The significance of appropriate control tissues
46. Diabetes-associated mesenteric vascular hypertrophy is attenuated by angiotensin-converting enzyme inhibition
47. Flow-induced dilatation in isolated resistance arteries from control and streptozotocin-diabetic rats
48. Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM 15639, in diabetic rats
49. Cardiac sympathetic neuropathy and effects of aldose reductase inhibitor in streptozotocin-induced diabetic rats
50. Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction and nerve blood flow in rats with streptozotocin-induced diabetes
51. Effect of diabetes on relaxations to non-adrenergic, non-cholinergic nerve stimulation in longitudinal muscle of the rat gastric fundus
52. Effects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed
53. Effect of chronic quinapril administration on heart rate variability in patients with diabetic autonomic neuropathy
54. α-Lipoic acid: Effect on glucose uptake, sorbitol pathway and energy metabolism in experimental diabetic neuropathy
55. Alpha-lipoic acid: Antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy
56. Hyperalgesia in spontaneous and experimental animal models of diabetic neuropathy
57. Daily insulin treatment relieves long-term hyperalgesia in streptozocin diabetic rats
58. Glutathione depletion in the lens of galactosemic and diabetic rats
59. Contraction and relaxation of aortas from galactosaemic rats and the effects of aldose reductase inhibition
60. Nerve function and regeneration in diabetic and galactosaemic rats: Antioxidant and metal chelator effects
61. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)
62. Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat
63. PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats
64. Protein kinase C activation and the development of diabetic complications
65. +-ATPase activity and glutathione content in diabetic rats
66. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats
67. Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat
68. Preserved acute pain and reduced neuropathic pain in mice lacking PKC gamma
69. Nerve growth factor administration protects against diabetic sensory neuropathy
70. Glycemic control of pain threshold in diabetic and control rats
71. Impaired sensory nerve function in insulin-resistant rats
72. A receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
73. Antinociceptive mechanism of Gosha-jinki-gan in streptozotocin-induced diabetic animals: Role of nitric oxide in the periphery