Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock

European Journal of Pharmacology

Volumn 527, Issue 1-3, 2005, Pages 163-171

  Di Paola, Rosanna ^a   Mazzon, Emanuela ^a   Xu, Weizheng ^b   Genovese, Tiziana ^a   Ferrraris, Dana ^b   Muià, Carmelo ^a   Crisafulli, Concetta ^a   Zhang, Jie ^b   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Colitis; GPI 15427; GPI 16539; Ischemia Reperfusion; Myeloperoxidase; PARP 1

Indexed keywords

ANTIINFLAMMATORY AGENT; DINITROBENZENE SULFONIC ACID; GPI 15427; GPI 16539; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITROBENZENE DERIVATIVE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY; ARTICLE; CELL INFILTRATION; COLITIS; COLON; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; ILEUM; IN VIVO STUDY; INFLAMMATORY CELL; INTESTINE INJURY; INTESTINE ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; REPERFUSION INJURY; SHOCK; SPLANCHNIC ARTERY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; COLITIS; COLON; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INTESTINES; MALE; NAPHTHYRIDINES; ORGANIC CHEMICALS; PIPERIDINES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; SHOCK; SPLANCHNIC CIRCULATION;

EID: 28544450635     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.09.055     Document Type: Article

References (29)

1. A.P. Caputi, F. Rossi, K. Carney, and H.E. Brezenoff Modulatory effect of brain acetylcholine on reflex-induced bradycardia and tachycardia in conscious rats J. Pharmacol. Exp. Ther. 215 1980 309 316
2. P.K. Chatterjee, S. Cuzzocrea, and C. Thiemermann Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against hydrogen peroxide-mediated oxidant stress Kidney Int. 56 1999 973 984
3. S. Cuzzocrea, B. Zingarelli, G. Costantino, A. Szabo, A.L. Salzman, A.P. Caputi, and C. Szabo Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion Br. J. Pharmacol. 121 1997 1065 1074
4. S. Cuzzocrea, M.C. McDonald, E. Mazzon, L. Dugo, I. Serraino, M. Threadgill, A.P Caputi, and C. Thiemermann Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury Biochem. Pharmacol. 63 2002 293 304
5. P. Decker, D. Isenberg, and S. Muller Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis J. Biol. Chem. 275 2000 9043 9046
6. G. de Murcia, V. Schreiber, M. Molinete, B. Saulier, O. Poch, M. Masson, C. Niedergang, and J. Menissier de Murcia Structure and function of poly(ADP-ribose) polymerase Mol. Cell Biochem. 138 1994 15 24
7. R. Di Paola, E. Mazzon, NS. Patel, T. Genovese, C. Muià, C. Thiemermann, A. DeSarro, and S. Cuzzocrea Beneficial effects of GW274150 treatment on development of experimental oditis induced by dinitrobenzene sulfonic acid Eur. J. Pharmacol. 507 2005 281 289
8. M.J. Eliasson, K. Sampei, A.S. Mandir, P.D. Hurn, R.J. Traystman, J. Bao, A. Pieper, Z.Q. Wang, T.M. Dawson, S.H. Snyder, and V.L. Dawson Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia Nat. Med. 3 1997 1089 1095
9. D. Ferraris, Y.S. Ko, T. Pahutski, R.P. Ficco, L. Serdyuk, C. Alemu, C. Bradford, T. Chiou, R. Hoover, S. Huang, S. Lautar, S. Liang, Q. Lin, M.X. Lu, M. Mooney, L. Morgan, Y. Qian, S. Tran, L.R. Williams, Q.Y. Wu, J. Zhang, Y. Zou, and V. Kalish Design and Synthesis of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors 2. Biological evaluation of aza-5[H]phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries J. Med. Chem. 46 2003 3138 3151
10. Z. Herceg, and Z.Q. Wang Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis Mol. Cell Biol. 19 1999 5124 5133
11. P.A. Jeggo DNA repair: PARP - another guardian angel? Curr. Biol. 8 1998 R49 R51
12. H.B. Jijon, T. Churchill, D. Malfair, A. Wessler, L.D. Jewell, H.G. Parsons, and K.L. Madsen Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis Am. J. Physiol.: Gasterointest. Liver Physiol. 279 2000 G641 G651
13. L. Liaudiet, F.G. Soriano, B. Zingarelli, C. Szabo, and A.L. Salzman Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase Proc. Natl. Acad. Sci. U. S. A. 97 2000 10203 10208
14. L. Liaudiet, A. Szabo, F.G. Soriano, B. Zingarelli, C. Szabo, and A.L. Salzman Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia Shock 14 2000 134 141
15. J.G. Mabley, P. Jagtap, M. Perretti, S.J. Getting, A.L. Salzman, L. Virag, E. Szabo, F.G. Soriano, L. Liaudet, G.E. Abdelkarim, G. Hasko, A. Marton, G.J. Southan, and C. Szabo Anti-inflammatory effects of a novel, potent inhibitor of poly(ADP-ribose) polymerase Inflamm. Res. 50 2001 561 569
16. E. Mazzon, L. Dugo, S.A. De, J.H. Li, A.P. Caputi, J. Zhang, and S. Cuzzocrea Beneficial effects of GPI 6150, an inhibitor of poly(ADP-ribose) polymerase in a rat model of splanchnic artery occlusion and reperfusion Shock 17 2002 222 227
17. E. Mazzon, L. Dugo, J.H. Li, R. Di Paola, T. Genovese, A.P. Caputi, J. Zhang, and S. Cuzzocrea GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat Biochem. Pharmacol. 64 2002 327 337
18. K.M. Mullane, R. Kraemer, and B. Smith Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium J. Pharmacol. Methods 14 1985 157 167
19. T. Nagayama, R.P. Simon, D. Chen, D.C. Henshall, W. Pei, R.A. Stetler, and J. Chen Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia J. Neurochem. 74 2000 1636 1645
20. A.A. Pieper, T. Walles, G. Wei, E.E. Clements, A. Verma, S.H. Snyder, and J.L. Zweier Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption Mol. Med. 6 2000 271 282
21. V. Rolli, M. O'Farrell, J. Menissier-de Murcia, and G. de Murcia Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching Biochemistry 36 1997 12147 12154
22. S. Sturiale, G. Barbara, and B. Qiu Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P Proc. Natl. Acad. Sci. U. S. A. 96 1999 11653 11658
23. C. Szabo, and V.L. Dawson Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion Trends Pharmacol. Sci. 19 1998 287 298
24. K. Takahashi, A.A. Pieper, S.E. Croul, J. Zhang, S.H. Snyder, and J.H. Greenberg Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia Brain Res. 829 1999 46 54
25. L. Tentori, C. Leonetti, M. Scarsella, G. d'Amati, M. Vergati, I. Portarena, W. Xu, V. Kalish, G. Zupi, J. Zhang, and G. Graziani Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, to increase temozolomide efficacy against intracranial melanoma, glioma, lymphoma Clinic. Cancer Res. 9 2003 5370 5379
26. L. Tentori, C. Leonetti, M. Scarsella, M. Vergati, W. Xu, D. Calvin, L. Morgan, Z. Tang, K. Wozniak, C. Alemu, R. Hoover, R. Lapidus, G. Zupi, J. Zhang, and G. Graziani Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors Int. J. Oncol. 26 2005 415 424
27. J.L. Wallace, C.M. Keenan, and D. Gale Exacerbation of experimental colitis by non-steroidal antiinflammatory drugs is not related to elevate leukotriene B4 synthesis Gastroenterology 102 1992 18 27
28. S.W. Yu, H. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, G.G. Poirier, T.M. Dawson, and V.L. Dawson Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor Science 297 2002 259 263
29. B. Zingarelli, A.L. Salzman, and C. Szabo Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury Circ. Res. 83 1998 85 94