Evidence that senescent human prostate epithelial cells enhance tumorigenicity: Cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT

International Journal of Cancer

Volumn 122, Issue 7, 2008, Pages 1483-1495

  Bhatia, Bobby ^a,d   Multani, Asha S ^b   Patrawala, Lubna ^a,e   Chen, Xin ^a   Calhoun Davis, Tammy ^a   Zhou, Jianjun ^a,f   Schroeder, Lisa ^a   Schneider Broussard, Robin ^a   Shen, Jianjun ^a   Pathak, Sen ^b   Chang, Sandy ^b   Tang, Dean G ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e ASURAGEN INC   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cell fusion; Cell senescence; hTERT; P16; Prostate epithelial cells

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE; PROTEIN P53; TELOMERASE; TERT PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL CULTURE; CARCINOGENICITY; CELL FUSION; CHROMOSOME ANALYSIS; EMBRYO; ENZYME INHIBITION; FIBROBLAST; GENE EXPRESSION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HYBRID CELL; KARYOTYPING; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; TUMOR GROWTH; CELL AGING; CELL TRANSFORMATION; EPITHELIUM CELL; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PROSTATE; PROSTATE TUMOR; SINGLE STRAND CONFORMATION POLYMORPHISM;

CELL AGING; CELL FUSION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EPITHELIAL CELLS; HUMANS; KARYOTYPING; MALE; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROSTATE; PROSTATIC NEOPLASMS; TELOMERASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 39649122634     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23222     Document Type: Article

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