Study Designs to Enhance Identification of Genetic Factors in Healthy Aging

Nutrition Reviews

Volumn 65, Issue SUPPL.3, 2007, Pages

  Manolio, Teri A ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Candidate gene; Complex trait; Familial; Genetic association; Genome wide association; Healthy aging; Trait

Indexed keywords

AGED; AGING; GENETIC MARKER; GENETICS; GENOME; GENOMICS; GENOTYPE; HEALTH STATUS; HUMAN; ORGANIZATION AND MANAGEMENT; PHENOTYPE; RESEARCH; REVIEW;

AGED, 80 AND OVER; AGING; GENETIC MARKERS; GENOME, HUMAN; GENOMICS; GENOTYPE; HEALTH STATUS; HUMANS; PHENOTYPE; RESEARCH;

EID: 39649107357     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2007.tb00368.x     Document Type: Article

References (33)

1. Newton-Cheh C, Hirschhorn JN. Genetic association studies of complex traits: design and analysis issues. Mutat Res 2005;573:54-69.
2. Ellsworth DL, Manolio TA. The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping. Ann Epidemiol 1999;9:75-90.
3. Bladbjerg EM, Andersen-Ranberg K, de Maat MP, et al. Longevity is independent of common variations in genes associated with cardiovascular risk. Thromb Haemost 1999;82:1100-1105.
4. Hsu HC, Scott DK, Zhang P, et al. CD8 T-cell immune phenotype of successful aging. Mech Ageing Dev 2006;127:231-239.
5. Goffaux J, Friesinger GC, Lambert W, et al. Biological age-a concept whose time has come: a preliminary study. South Med J 2005;98:985-993.
6. van de Water HP, Perenboom RJ, Boshuizen HC. Policy relevance of the health expectancy indicator; an inventory in European Union countries. Health Policy 1996;36:117-129.
7. Perls T, Shea-Drinkwater M, Bowen-Flynn J, et al. Exceptional familial clustering for extreme longevity in humans. J Am Geriatr Soc 2000;48:1483-1485.
8. Risch N, Teng J. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling. Genome Res 1998;8:1273-1288.
9. Teng J, Risch N. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res 1999;9:234-241.
10. Frederiksen H, Gaist D, Petersen HC, et al. Hand grip strength: a phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning. Genet Epidemiol 2002;23:110-122.
11. Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer. Lancet 1998;351:1560.
12. Seripa D, Franceschi M, Matera MG, et al. Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. J Gerontol A Biol Sci Med Sci 2006;61:918-923.
13. Ordovas JM, Mooser V. The APOE locus and the pharmacogenetics of lipid response. Curr Opin Lipi-dol 2002;13:113-117.
14. Teter B. ApoE-dependent plasticity in Alzheimer's disease. J Mol Neurosci 2004;23:167-179.
15. Gudmundsson J, Sulem P, Manolescu A, et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet 2007;39:631-637.
16. Haiman CA, Patterson N, Freedman ML, et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 2007;39:638-644.
17. Yeager M, Orr N, Hayes RB, et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 2007;39:645-649.
18. Puca AA, Daly MJ, Brewster SJ, et al. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 2001;98:10505-10508.
19. Easton DF, Ford D, Bishop DT. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet 1995;56:265-271.
20. Futreal PA, Liu Q, Shattuck-Eidens D, et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994;266:120-122.
21. Vehmanen P, Friedman LS, Eerola H, et al. Low proportion of BRCA1 and BRCA2 mutations in Finnish breast cancer families: evidence for additional susceptibility genes. Hum Mol Genet 1997;6:2309-2315.
22. Ellsworth DL, Manolio TA. The emerging importance of genetics in epidemiologic research. I. Basic concepts in human genetics and laboratory technology. Ann Epidemiol 1999;9:1-16.
23. A haplotype map of the human genome. Nature 2005;437:1299-1320.
24. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005;308:385-389.
25. Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sanchez-Corral P. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol 2004;41:355-367.
26. Dewan A, Liu M, Hartman S, et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science 2006;314:989-992.
27. Genetic Association Information Network (GAIN) http:www.fnih.orgGAIN2home_new.shtml.
28. NCI's Cancer Genetic Markers of Susceptibility (CGEMS). Available at: cgems.cancer.gov. Accessed October 21, 2007.
29. National Heart Lung and Blood Institute (NHLBI) Framingham Study. Available at: http:www.nhlbi.nih.govaboutframinghamindex.html. Accessed October 21, 2007.
30. National Heart Lung and Blood Institute SNP Genotyping and Analysis Program. Available at: http:www.nhlbi.nih.govmeetingsworkshopsfuture-genotyping.htm. Accessed October 21, 2007.
31. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes Complications study. Available at: http:diabetes.niddk.nih.gov. Accessed October 21, 2007.
32. Ordovas JM, Corella D, Demissie S, et al. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation 2002;106:2315-2321.
33. Chanock SJ, Manolio T, Boehnke M, et al. NCI-NHGRI Working Group on Replication in Association Studies. Replicating genotype-phenotype associations. Nature 2007;447:655-660.