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Volumn 9, Issue 2, 1999, Pages 75-90

The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping

Author keywords

Epidemiologic Methods; Genetic Markers; Genetic Techniques; Hereditary Diseases; Human Genome; Mapping; Molecular Epidemiology; Phenotype

Indexed keywords

ARTICLE; GENE MAPPING; GENETIC POLYMORPHISM; HEREDITY; HUMAN; MEDICAL GENETICS; POPULATION RESEARCH; PRIORITY JOURNAL; RISK FACTOR;

EID: 0033007161     PISSN: 10472797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1047-2797(98)00064-7     Document Type: Article
Times cited : (42)

References (54)
  • 2
    • 0032496881 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Gene discovery and its implications for population-based screening
    • Burke W., Thomson E., Khoury M.J., McDonnell S.M., Press N., Adams P.C.et al. Hereditary hemochromatosis. Gene discovery and its implications for population-based screening JAMA. 280:1998;172-178.
    • (1998) JAMA. , vol.280 , pp. 172-178
    • Burke, W.1    Thomson, E.2    Khoury, M.J.3    McDonnell, S.M.4    Press, N.5    Adams, P.C.6
  • 3
    • 0003097704 scopus 로고    scopus 로고
    • Classification of the asthma phenotype in genetic studies
    • S.B. Liggett, & D.A. Meyers. New York: Marcel Dekker
    • Wiesch D.G., Samet J.M., Bleecker E.R., Meyers D.A. Classification of the asthma phenotype in genetic studies. Liggett S.B., Meyers D.A. The Genetics of Asthma. 1996;421-442 Marcel Dekker, New York.
    • (1996) The Genetics of Asthma , pp. 421-442
    • Wiesch, D.G.1    Samet, J.M.2    Bleecker, E.R.3    Meyers, D.A.4
  • 4
    • 0002766766 scopus 로고    scopus 로고
    • Issues in phenotype assessment in genetic studies of asthma
    • S.B. Liggett, & D.A. Meyers. New York: Marcel Dekker
    • Weiss S.T. Issues in phenotype assessment in genetic studies of asthma. Liggett S.B., Meyers D.A. The Genetics of Asthma. 1996;401-419 Marcel Dekker, New York.
    • (1996) The Genetics of Asthma , pp. 401-419
    • Weiss, S.T.1
  • 6
    • 0030002580 scopus 로고    scopus 로고
    • The progression from hypertension to congestive heart failure
    • Levy D., Larson M.G., Vasan R.S., Kannel W.B., Ho K.K.L. The progression from hypertension to congestive heart failure. JAMA. 275:1996;1557-1562.
    • (1996) JAMA. , vol.275 , pp. 1557-1562
    • Levy, D.1    Larson, M.G.2    Vasan, R.S.3    Kannel, W.B.4    Ho, K.K.L.5
  • 7
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions
    • The SOLVD Investigators Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 327:1992;685-691.
    • (1992) N Engl J Med. , vol.327 , pp. 685-691
    • The Solvd Investigators1
  • 8
    • 0025887188 scopus 로고
    • Use of sonography to evaluate carotid atherosclerosis in the elderly. The Cardiovascular Health Study. CHS Collaborative Research Group
    • O'Leary D.H., Polak J.F., Wolfson S.K. Jr., Bond M.G., Bommer W., Sheth S.et al. Use of sonography to evaluate carotid atherosclerosis in the elderly. The Cardiovascular Health Study. CHS Collaborative Research Group. Stroke. 22:1991;1155-1163.
    • (1991) Stroke. , vol.22 , pp. 1155-1163
    • O'Leary, D.H.1    Polak, J.F.2    Wolfson S.K., Jr.3    Bond, M.G.4    Bommer, W.5    Sheth, S.6
  • 10
    • 0024235157 scopus 로고
    • The impact of varying diagnostic thresholds on affected sib pair linkage analysis
    • Kendler K.S. The impact of varying diagnostic thresholds on affected sib pair linkage analysis. Genet Epidemiol. 5:1988;407-419.
    • (1988) Genet Epidemiol. , vol.5 , pp. 407-419
    • Kendler, K.S.1
  • 11
    • 0026529005 scopus 로고
    • Model misspecification and multipoint linkage analysis
    • Risch N., Giuffra L. Model misspecification and multipoint linkage analysis. Hum Heredity. 42:1992;77-92.
    • (1992) Hum Heredity. , vol.42 , pp. 77-92
    • Risch, N.1    Giuffra, L.2
  • 12
    • 0029001682 scopus 로고
    • Extreme discordant sib pairs for mapping quantitative trait loci in humans
    • Risch N., Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science. 268:1995;1584-1589.
    • (1995) Science. , vol.268 , pp. 1584-1589
    • Risch, N.1    Zhang, H.2
  • 13
    • 0027053029 scopus 로고
    • An overview of methods for the analysis of longitudinal data
    • Zeger S.L., Liang K.Y. An overview of methods for the analysis of longitudinal data. Stat Med. 11:1992;1825-1839.
    • (1992) Stat Med. , vol.11 , pp. 1825-1839
    • Zeger, S.L.1    Liang, K.Y.2
  • 14
    • 0030068024 scopus 로고    scopus 로고
    • Molecular genetics of human blood pressure variation
    • Lifton R.P. Molecular genetics of human blood pressure variation. Science. 272:1996;676-680.
    • (1996) Science. , vol.272 , pp. 676-680
    • Lifton, R.P.1
  • 16
    • 0344856560 scopus 로고    scopus 로고
    • Approaches to family studies of asthma
    • S.B. Liggett, & D.A. Meyers. New York: Marcel Dekker
    • Postma D.S., Meyers D.A. Approaches to family studies of asthma. Liggett S.B., Meyers D.A. The Genetics of Asthma. 1996;443-453 Marcel Dekker, New York.
    • (1996) The Genetics of Asthma , pp. 443-453
    • Postma, D.S.1    Meyers, D.A.2
  • 17
  • 18
    • 0027418055 scopus 로고
    • Twin studies in medical research: Can they tell us whether diseases are genetically determined?
    • Phillips D.I.W. Twin studies in medical research. Can they tell us whether diseases are genetically determined? Lancet. 341:1993;1008-1009.
    • (1993) Lancet. , vol.341 , pp. 1008-1009
    • Phillips, D.I.W.1
  • 20
    • 0028039828 scopus 로고
    • DNA analysis in forensics, disease, and animal/plant identification
    • Alford R.L., Caskey C.T. DNA analysis in forensics, disease, and animal/plant identification. Curr Opin Biotechnol. 5:1994;29-33.
    • (1994) Curr Opin Biotechnol. , vol.5 , pp. 29-33
    • Alford, R.L.1    Caskey, C.T.2
  • 21
    • 0030662348 scopus 로고    scopus 로고
    • A twin-pronged attack on complex traits
    • Martin N., Boomsma D., Machin G. A twin-pronged attack on complex traits. Nat Genet. 17:1997;387-392.
    • (1997) Nat Genet. , vol.17 , pp. 387-392
    • Martin, N.1    Boomsma, D.2    Machin, G.3
  • 22
    • 0031886107 scopus 로고    scopus 로고
    • Candidate-gene studies of the atherogenic lipoprotein phenotype: A sib-pair linkage analysis of DZ women twins
    • Austin M.A., Talmud P.J., Luong L.-A., Haddad L., Day I.N.M., Newman B.et al. Candidate-gene studies of the atherogenic lipoprotein phenotype. A sib-pair linkage analysis of DZ women twins Am J Hum Genet. 62:1998;406-419.
    • (1998) Am J Hum Genet. , vol.62 , pp. 406-419
    • Austin, M.A.1    Talmud, P.J.2    Luong, L.-A.3    Haddad, L.4    Day, I.N.M.5    Newman, B.6
  • 24
    • 0026778869 scopus 로고
    • Evidence for independent genetic influences on obesity in middle age
    • Fabsitz R.R., Carmelli D., Hewitt J.K. Evidence for independent genetic influences on obesity in middle age. Int J Obes. 16:1992;657-666.
    • (1992) Int J Obes. , vol.16 , pp. 657-666
    • Fabsitz, R.R.1    Carmelli, D.2    Hewitt, J.K.3
  • 25
    • 9044243415 scopus 로고    scopus 로고
    • A genomewide search for human noninsulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
    • Hanis C.L., Boerwinkle E., Chakraborty R., Ellsworth D.L., Concannon P., Stirling B.et al. A genomewide search for human noninsulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet. 13:1996;161-166.
    • (1996) Nat Genet. , vol.13 , pp. 161-166
    • Hanis, C.L.1    Boerwinkle, E.2    Chakraborty, R.3    Ellsworth, D.L.4    Concannon, P.5    Stirling, B.6
  • 26
    • 0031019091 scopus 로고    scopus 로고
    • Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
    • Nichols W.C., Koller D.L., Slovis B., Foroud T., Terry V.H., Arnold N.D.et al. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat Genet. 15:1997;277-280.
    • (1997) Nat Genet. , vol.15 , pp. 277-280
    • Nichols, W.C.1    Koller, D.L.2    Slovis, B.3    Foroud, T.4    Terry, V.H.5    Arnold, N.D.6
  • 27
    • 0022881371 scopus 로고
    • Genetic analysis of cystic fibrosis: Linkage of DNA and classical markers in multiplex families
    • Bowcock A.M., Crandall J., Daneshvar L., Lee G.M., Young B., Zunzunegui V.et al. Genetic analysis of cystic fibrosis. Linkage of DNA and classical markers in multiplex families Am J Hum Genet. 39:1986;699-706.
    • (1986) Am J Hum Genet. , vol.39 , pp. 699-706
    • Bowcock, A.M.1    Crandall, J.2    Daneshvar, L.3    Lee, G.M.4    Young, B.5    Zunzunegui, V.6
  • 28
    • 0026545454 scopus 로고
    • Multiple mutation in an extended Duchenne muscular dystrophy family
    • Miciak A., Keen A., Jadayel D., Bundey S. Multiple mutation in an extended Duchenne muscular dystrophy family. J Med Genet. 29:1992;123-126.
    • (1992) J Med Genet. , vol.29 , pp. 123-126
    • Miciak, A.1    Keen, A.2    Jadayel, D.3    Bundey, S.4
  • 30
    • 0031942841 scopus 로고    scopus 로고
    • Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes Group
    • Imperatore G., Hanson R.L., Pettitt D.J., Kobes S., Bennett P.H., Knowler W.C. Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes Group. Diabetes. 47:1998;821-830.
    • (1998) Diabetes. , vol.47 , pp. 821-830
    • Imperatore, G.1    Hanson, R.L.2    Pettitt, D.J.3    Kobes, S.4    Bennett, P.H.5    Knowler, W.C.6
  • 31
    • 13344260701 scopus 로고    scopus 로고
    • A genomewide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish
    • Ginns E.I., Ott J., Egeland J.A., Allen C.R., Fann C.S., Pauls D.L.et al. A genomewide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet. 12:1996;431-435.
    • (1996) Nat Genet. , vol.12 , pp. 431-435
    • Ginns, E.I.1    Ott, J.2    Egeland, J.A.3    Allen, C.R.4    Fann, C.S.5    Pauls, D.L.6
  • 32
    • 0028832051 scopus 로고
    • Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men
    • Stengård J.H., Zerba K.E., Pekkanen J., Ehnholm C., Nissinen A., Sing C.F. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation. 91:1995;265-269.
    • (1995) Circulation. , vol.91 , pp. 265-269
    • Stengård, J.H.1    Zerba, K.E.2    Pekkanen, J.3    Ehnholm, C.4    Nissinen, A.5    Sing, C.F.6
  • 33
    • 0031679495 scopus 로고    scopus 로고
    • Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population
    • Pastinen T., Perola M., Niini P., Terwilliger J., Salomaa V., Vartiainen E.et al. Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population. Hum Mol Genet. 7:1998;1453-1462.
    • (1998) Hum Mol Genet. , vol.7 , pp. 1453-1462
    • Pastinen, T.1    Perola, M.2    Niini, P.3    Terwilliger, J.4    Salomaa, V.5    Vartiainen, E.6
  • 35
    • 0023897329 scopus 로고
    • Genetic factors affecting blood lipoproteins: The candidate gene approach
    • Lusis A.J. Genetic factors affecting blood lipoproteins. The candidate gene approach J Lipid Res. 29:1988;397-429.
    • (1988) J Lipid Res. , vol.29 , pp. 397-429
    • Lusis, A.J.1
  • 36
    • 0000461955 scopus 로고
    • Atherosclerosis: An understanding of the cellular and molecular basis of the disease promises new approaches for its treatment in the near future
    • Hajjar D.P., Nicholson A.C. Atherosclerosis. An understanding of the cellular and molecular basis of the disease promises new approaches for its treatment in the near future Am Scientist. 83:1995;460-467.
    • (1995) Am Scientist. , vol.83 , pp. 460-467
    • Hajjar, D.P.1    Nicholson, A.C.2
  • 37
    • 0027532914 scopus 로고
    • Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO ad hoc diabetes reporting group
    • King H., Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO ad hoc diabetes reporting group. Diabetes Care. 16:1993;157-177.
    • (1993) Diabetes Care. , vol.16 , pp. 157-177
    • King, H.1    Rewers, M.2
  • 38
    • 0031914679 scopus 로고    scopus 로고
    • Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
    • Hattersley A.T. Maturity-onset diabetes of the young. Clinical heterogeneity explained by genetic heterogeneity Diabet Med. 15:1998;15-24.
    • (1998) Diabet Med. , vol.15 , pp. 15-24
    • Hattersley, A.T.1
  • 39
    • 0029150074 scopus 로고
    • A comparison of linkage disequilibrium measures for fine-scale mapping
    • Devlin B., Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics. 29:1995;311-322.
    • (1995) Genomics. , vol.29 , pp. 311-322
    • Devlin, B.1    Risch, N.2
  • 40
    • 0030994211 scopus 로고    scopus 로고
    • Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications
    • Xiong M., Guo S.-W. Fine-scale genetic mapping based on linkage disequilibrium. Theory and applications Am J Hum Genet. 60:1997;1513-1531.
    • (1997) Am J Hum Genet. , vol.60 , pp. 1513-1531
    • Xiong, M.1    Guo, S.-W.2
  • 41
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis
    • Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A.et al. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet. 13:1996;399-408.
    • (1996) Nat Genet. , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3    Tsuchihashi, Z.4    Ruddy, D.A.5    Basava, A.6
  • 43
    • 0024980741 scopus 로고
    • A common language for physical mapping of the human genome
    • Olson M., Hood L., Cantor C., Botstein D. A common language for physical mapping of the human genome. Science. 245:1989;1434-1435.
    • (1989) Science. , vol.245 , pp. 1434-1435
    • Olson, M.1    Hood, L.2    Cantor, C.3    Botstein, D.4
  • 44
    • 0030063730 scopus 로고    scopus 로고
    • Energy transfer primers: A new fluorescence labeling paradigm for DNA sequencing and analysis
    • Ju J., Glazer A.N., Mathies R.A. Energy transfer primers. A new fluorescence labeling paradigm for DNA sequencing and analysis Nat Med. 2:1996;246-249.
    • (1996) Nat Med. , vol.2 , pp. 246-249
    • Ju, J.1    Glazer, A.N.2    Mathies, R.A.3
  • 45
    • 0032540905 scopus 로고    scopus 로고
    • A sequencing method based on real-time pyrophosphate
    • Ronaghi M., Uhlén M., Nyrén P. A sequencing method based on real-time pyrophosphate. Science. 281:1998;363-365.
    • (1998) Science. , vol.281 , pp. 363-365
    • Ronaghi, M.1    Uhlén, M.2    Nyrén, P.3
  • 48
    • 0026849567 scopus 로고
    • Positional cloning: Let's not call it reverse anymore (News)
    • Collins F.S. Positional cloning. Let's not call it reverse anymore (News) Nat Genet. 1:1992;3-6.
    • (1992) Nat Genet. , vol.1 , pp. 3-6
    • Collins, F.S.1
  • 49
    • 0028907339 scopus 로고
    • Positional cloning moves from perditional to traditional
    • Collins F.S. Positional cloning moves from perditional to traditional. Nat Genet. 9:1995;347-350.
    • (1995) Nat Genet. , vol.9 , pp. 347-350
    • Collins, F.S.1
  • 51
    • 0028296185 scopus 로고
    • Mining treasures from "junk DNA" (News)
    • Nowak R. Mining treasures from "junk DNA" (News). Science. 263:1994;608-610.
    • (1994) Science. , vol.263 , pp. 608-610
    • Nowak, R.1
  • 54
    • 0030013386 scopus 로고    scopus 로고
    • Mapping the RP10 locus for autosomal dominant retinitis pigmentosa on 7q: Refined genetic positioning and localization within a well-defined YAC contig
    • McGuire R.E., Jordan S.A., Braden V.V., Bouffard G.G., Humphries P., Green E.D.et al. Mapping the RP10 locus for autosomal dominant retinitis pigmentosa on 7q. Refined genetic positioning and localization within a well-defined YAC contig Genome Res. 6:1996;255-266.
    • (1996) Genome Res. , vol.6 , pp. 255-266
    • McGuire, R.E.1    Jordan, S.A.2    Braden, V.V.3    Bouffard, G.G.4    Humphries, P.5    Green, E.D.6


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