Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Nature Genetics

Volumn 39, Issue 5, 2007, Pages 645-649

  Yeager, Meredith ^a,b   Orr, Nick ^b   Hayes, Richard B ^b   Jacobs, Kevin B ^c   Kraft, Peter ^d   Wacholder, Sholom ^b   Minichiello, Mark J ^e   Fearnhead, Paul ^f   Yu, Kai ^b   Chatterjee, Nilanjan ^b   Wang, Zhaoming ^a,b   Welch, Robert ^a,b   Staats, Brian J ^a,b   Calle, Eugenia E ^g   Feigelson, Heather Spencer ^g   Thun, Michael J ^g   Rodriguez, Carmen ^g   Albanes, Demetrius ^b   Virtamo, Jarmo ^h   Weinstein, Stephanie ^b   Schumacher, Fredrick R ^d   Giovannucci, Edward ^d   Willett, Walter C ^d   Cancel Tassin, Geraldine ⁱ   Cussenot, Olivier ⁱ   Valeri, Antoine ⁱ   Andriole, Gerald L ^j   Gelmann, Edward P ^k   Tucker, Margaret ^b   Gerhard, Daniela S ^l   Fraumeni Jr , Joseph F ^b   Hoover, Robert ^b   Hunter, David J ^b,d   Chanock, Stephen J ^b   Thomas, Gilles ^b   more..

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Bioinformed Consulting Services   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f LANCASTER UNIVERSITY   (United Kingdom)

^g AMERICAN CANCER SOCIETY   (United States)

^h NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

ⁱ ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^j WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k Och Spine at New York Presbyterian Hospitals   (United States)

^l NATIONAL INSTITUTES OF HEALTH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER EPIDEMIOLOGY; CANCER GENETICS; CANCER RISK; CANCER SUSCEPTIBILITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOME; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

AFRICAN AMERICANS; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 8; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MOLECULAR SEQUENCE DATA; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; RISK FACTORS; UNITED STATES; VARIATION (GENETICS);

EID: 34247548755     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng2022     Document Type: Article

References (26)

1. Crawford, E.D. Epidemiology of prostate cancer. Urology 62, 3-12 (2003).
2. Parkin, D.M. et al. Cancer Incidence in Five Continents (IARC Scientific Publications, Lyon, 2002).
3. Steinberg, G.D., Carter, B.S., Beaty, T.H., Childs, B. & Walsh, P.C. Family history and the risk of prostate cancer. Prostate 17, 337-347 (1990).
4. Freedman, M.L. et al. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc. Natl. Acad. Sci. USA 103, 14068-14073 (2006).
5. Amundadottir, L.T. et al. A common variant associated with prostate cancer in European and African populations. Nat. Genet. 38, 652-658 (2006).
6. Schumacher, F.R. et al. Prostate cancer risk and 8q24. Cancer Res. (in the press).
7. Gohagan, J.K., Prorok, P.C., Hayes, R.B. & Kramer, B.S. The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial of the National Cancer Institute: history, organization, and status. Control. Clin. Trials 21, 251S-272S (2000).
8. Prorok, P.C. et al. Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control. Clin. Trials 21, 273S-309S (2000).
9. Phillips, M.S. et al. Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat. Genet. 33, 382-387 (2003).
10. Calle, E.E. et al. The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer 94, 2490-2501 (2002).
11. Chen, Y.C. et al. Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer. Cancer Res. 65, 11771-11778 (2005).
12. Valeri, A. et al. Segregation analysis of prostate cancer in France: evidence for autosomal dominant inheritance and residual brother-brother dependence. Ann. Hum. Genet. 67, 125-137 (2003).
13. The ATBC Cancer Prevention Study Group. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics and compliance. Ann. Epidemiol. 4, 1-10 (1994).
14. Fearnhead, P. SequenceLDhot: detecting recombination hotspots. Bioinformatics 22, 3061-3066 (2006).
15. Myers, S., Bottolo, L., Freeman, C., McVean, G. & Donnelly, P. A fine-scale map of recombination rates and hotspots across the human genome. Science 310, 321-324 (2005).
16. The International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
17. Minichiello, M.J. & Durbin, R. Mapping trait loci by use of inferred ancestral recombination graphs. Am. J. Hum. Genet. 79, 910-922 (2006).
18. Stephens, M., Smith, N.J. & Donnelly, P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978-989 (2001).
19. Stephens, M. & Scheet, P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am. J. Hum. Genet. 76, 449-462 (2005).
20. Nupponen, N.N., Kakkola, L., Koivisto, P. & Visakorpi, T. Genetic alterations in hormone-refractory recurrent prostate carcinomas. Am. J. Pathol. 153, 141-148 (1998).
21. Cher, M.L. et al. Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res. 56, 3091-3102 (1996).
22. Bruzzi, P., Green, S.B., Byar, D.P., Brinton, L.A. & Schairer, C. Estimating the population attributable risk for multiple risk factors using case-control data. Am. J. Epidemiol. 122, 904-914 (1985).
23. Wacholder, S., Benichou, J., Heineman, E.F., Hartge, P. & Hoover, R.N. Attributable risk: advantages of a broad definition of exposure. Am. J. Epidemiol. 140, 303-309 (1994).
24. Seldin, M.F. et al. European population substructure: clustering of northern and southern populations. PLoS Genet. 2, e143 (2006).
25. Saarela, J. et al. PRKCA and multiple sclerosis: association in two independent populations. PLoS Genet. 2, e42 (2006).
26. Willer, C.J. et al. Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet. Epidemiol. 30, 180-190 (2006).