메뉴 건너뛰기




Volumn 74, Issue 4, 2008, Pages 1243-1249

Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOSYNTHESIS; CELL CULTURE; GROWTH KINETICS; PROTEINS;

EID: 39649091205     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.02151-07     Document Type: Article
Times cited : (24)

References (33)
  • 1
    • 8444247042 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA
    • Ashkar, A. A., X. D. Yao, N. Gill, D. Sajic, A. J. Patrick, and K. L. Rosenthal. 2004. Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA. J. Infect. Dis. 190:1841-1849.
    • (2004) J. Infect. Dis , vol.190 , pp. 1841-1849
    • Ashkar, A.A.1    Yao, X.D.2    Gill, N.3    Sajic, D.4    Patrick, A.J.5    Rosenthal, K.L.6
  • 2
    • 33745188914 scopus 로고    scopus 로고
    • Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium
    • Balakrishnan, A., B. Patel, S. A. Sieber, D. Chen, N. Pachikara, G. Zhong, B. F. Cravatt, and H. Fan. 2006. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J. Biol. Chem. 281:16691-16699.
    • (2006) J. Biol. Chem , vol.281 , pp. 16691-16699
    • Balakrishnan, A.1    Patel, B.2    Sieber, S.A.3    Chen, D.4    Pachikara, N.5    Zhong, G.6    Cravatt, B.F.7    Fan, H.8
  • 3
    • 32244447356 scopus 로고    scopus 로고
    • Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis
    • Beatty, W. L. 2006. Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis. J. Cell Sci. 119:350-359.
    • (2006) J. Cell Sci , vol.119 , pp. 350-359
    • Beatty, W.L.1
  • 4
    • 1842486666 scopus 로고    scopus 로고
    • Chlamydia pneumoniae - an infectious risk factor for atherosclerosis?
    • Campbell, L. A., and C. C. Kuo. 2004. Chlamydia pneumoniae - an infectious risk factor for atherosclerosis? Nat. Rev. Microbiol. 2:23-32.
    • (2004) Nat. Rev. Microbiol , vol.2 , pp. 23-32
    • Campbell, L.A.1    Kuo, C.C.2
  • 5
    • 0037974695 scopus 로고    scopus 로고
    • Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion
    • Carabeo, R. A., D. J. Mead, and T. Hackstadt. 2003. Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion. Proc. Natl. Acad. Sci. USA 100:6771-6776.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6771-6776
    • Carabeo, R.A.1    Mead, D.J.2    Hackstadt, T.3
  • 6
    • 33845794818 scopus 로고    scopus 로고
    • Involvement of protein kinase Cδ in iron chelator-induced IL-8 production in human intestinal epithelial cells
    • Choi, E. Y., S. Lee, H. M. Oh, Y. D. Kim, E. J. Choi, S. H. Kim, S. W. Kim, S. C. Choi, and C. D. Jun. 2007. Involvement of protein kinase Cδ in iron chelator-induced IL-8 production in human intestinal epithelial cells. Life Sci. 80:436-445.
    • (2007) Life Sci , vol.80 , pp. 436-445
    • Choi, E.Y.1    Lee, S.2    Oh, H.M.3    Kim, Y.D.4    Choi, E.J.5    Kim, S.H.6    Kim, S.W.7    Choi, S.C.8    Jun, C.D.9
  • 7
    • 0037443030 scopus 로고    scopus 로고
    • Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance
    • Clark, A. S., K. A. West, P. M. Blumberg, and P. A. Dennis. 2003. Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance. Cancer Res. 63:780-786.
    • (2003) Cancer Res , vol.63 , pp. 780-786
    • Clark, A.S.1    West, K.A.2    Blumberg, P.M.3    Dennis, P.A.4
  • 8
    • 34247163593 scopus 로고    scopus 로고
    • Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection
    • Cong, Y., M. Jupelli, M. N. Guentzel, G. Zhong, A. K. Murthy, and B. P. Arulanandam. 2007. Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection. Vaccine 25:3773-3780.
    • (2007) Vaccine , vol.25 , pp. 3773-3780
    • Cong, Y.1    Jupelli, M.2    Guentzel, M.N.3    Zhong, G.4    Murthy, A.K.5    Arulanandam, B.P.6
  • 9
    • 33644831828 scopus 로고    scopus 로고
    • Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells
    • Deka, S., J. Vanover, S. Dessus-Babus, J. Whittimore, M. K. Howett, P. B. Wyrick, and R. V. Schoborg. 2006. Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells. Cell. Microbiol. 8:149-162.
    • (2006) Cell. Microbiol , vol.8 , pp. 149-162
    • Deka, S.1    Vanover, J.2    Dessus-Babus, S.3    Whittimore, J.4    Howett, M.K.5    Wyrick, P.B.6    Schoborg, R.V.7
  • 11
    • 0346251026 scopus 로고    scopus 로고
    • Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis
    • Greene, W., Y. Xiao, Y. Huang, G. McClarty, and G. Zhong. 2004. Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis. Infect. Immun. 72:451-460.
    • (2004) Infect. Immun , vol.72 , pp. 451-460
    • Greene, W.1    Xiao, Y.2    Huang, Y.3    McClarty, G.4    Zhong, G.5
  • 12
    • 4644340359 scopus 로고    scopus 로고
    • Ceramide trafficking: Learning from the rebels
    • Gupta, G. D. 2004. Ceramide trafficking: learning from the rebels. J. Biosci. 29:209-210.
    • (2004) J. Biosci , vol.29 , pp. 209-210
    • Gupta, G.D.1
  • 14
    • 0029871027 scopus 로고    scopus 로고
    • Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane
    • Hackstadt, T., D. D. Rockey, R. A. Heinzen, and M. A. Scidmore. 1996. Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane. EMBO J. 15:964-977.
    • (1996) EMBO J , vol.15 , pp. 964-977
    • Hackstadt, T.1    Rockey, D.D.2    Heinzen, R.A.3    Scidmore, M.A.4
  • 15
    • 0029034043 scopus 로고
    • Lipid metabolism in Chlamydia trachomatis-infected cells: Directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion
    • Hackstadt, T., M. A. Scidmore, and D. D. Rockey. 1995. Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proc. Natl. Acad. Sci. USA 92: 4877-4881.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4877-4881
    • Hackstadt, T.1    Scidmore, M.A.2    Rockey, D.D.3
  • 16
    • 0033105576 scopus 로고    scopus 로고
    • The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae
    • Hu, H., G. N. Pierce, and G. Zhong. 1999. The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J. Clin. Investig. 103:747-753.
    • (1999) J. Clin. Investig , vol.103 , pp. 747-753
    • Hu, H.1    Pierce, G.N.2    Zhong, G.3
  • 17
    • 8444241833 scopus 로고    scopus 로고
    • Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells
    • Kuriyama, M., T. Taniguchi, Y. Shirai, A. Sasaki, A. Yoshimura, and N. Saito. 2004. Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem. Biophys. Res. Commun. 325:843-851.
    • (2004) Biochem. Biophys. Res. Commun , vol.325 , pp. 843-851
    • Kuriyama, M.1    Taniguchi, T.2    Shirai, Y.3    Sasaki, A.4    Yoshimura, A.5    Saito, N.6
  • 18
    • 34249710152 scopus 로고    scopus 로고
    • Characterization of hypothetical proteins Cpn0146, 0147, 0284 and 0285 that are predicted to be in the Chlamydia pneumoniae inclusion membrane
    • Luo, J., G. Liu, Y. Zhong, T. Jia, K. Liu, D. Chen, and G. Zhong. 2007. Characterization of hypothetical proteins Cpn0146, 0147, 0284 and 0285 that are predicted to be in the Chlamydia pneumoniae inclusion membrane. BMC Microbiol. 7:38.
    • (2007) BMC Microbiol , vol.7 , pp. 38
    • Luo, J.1    Liu, G.2    Zhong, Y.3    Jia, T.4    Liu, K.5    Chen, D.6    Zhong, G.7
  • 20
    • 0035839635 scopus 로고    scopus 로고
    • PKCδ is required for mitochondrial-dependent apoptosis in salivary epithelial cells
    • Matassa, A. A., L. Carpenter, T. J. Biden, M. J. Humphries, and M. E. Reyland. 2001. PKCδ is required for mitochondrial-dependent apoptosis in salivary epithelial cells. J. Biol. Chem. 276:29719-29728.
    • (2001) J. Biol. Chem , vol.276 , pp. 29719-29728
    • Matassa, A.A.1    Carpenter, L.2    Biden, T.J.3    Humphries, M.J.4    Reyland, M.E.5
  • 21
    • 0037305123 scopus 로고    scopus 로고
    • Restricted fusion of Chlamydia trachomatis vesicles with endocytic compartments during the initial stages of infection
    • Scidmore, M. A., E. R. Fischer, and T. Hackstadt. 2003. Restricted fusion of Chlamydia trachomatis vesicles with endocytic compartments during the initial stages of infection. Infect. Immun. 71:973-984.
    • (2003) Infect. Immun , vol.71 , pp. 973-984
    • Scidmore, M.A.1    Fischer, E.R.2    Hackstadt, T.3
  • 23
    • 34548511124 scopus 로고    scopus 로고
    • Rottlerin: An inappropriate and ineffective inhibitor of PKCδ
    • Soltoff, S. P. 2007. Rottlerin: an inappropriate and ineffective inhibitor of PKCδ. Trends Pharmacol. Sci. 28:453-458.
    • (2007) Trends Pharmacol. Sci , vol.28 , pp. 453-458
    • Soltoff, S.P.1
  • 25
    • 1542334775 scopus 로고    scopus 로고
    • Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids
    • Su, H., G. McClarty, F. Dong, G. M. Hatch, Z. K. Pan, and G. Zhong. 2004. Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J. Biol. Chem. 279:9409-9416.
    • (2004) J. Biol. Chem , vol.279 , pp. 9409-9416
    • Su, H.1    McClarty, G.2    Dong, F.3    Hatch, G.M.4    Pan, Z.K.5    Zhong, G.6
  • 26
    • 0043016254 scopus 로고    scopus 로고
    • Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C
    • Tillman, D. M., K. Izeradjene, K. S. Szucs, L. Douglas, and J. A. Houghton. 2003. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer Res. 63:5118-5125.
    • (2003) Cancer Res , vol.63 , pp. 5118-5125
    • Tillman, D.M.1    Izeradjene, K.2    Szucs, K.S.3    Douglas, L.4    Houghton, J.A.5
  • 27
    • 21644436126 scopus 로고    scopus 로고
    • Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: Possible role in the inhibition of host cell apoptosis
    • Tse, S. M., D. Mason, R. J. Botelho, B. Chiu, M. Reyland, K. Hanada, R. D. Inman, and S. Grinstein. 2005. Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. J. Biol. Chem. 280:25210-25215.
    • (2005) J. Biol. Chem , vol.280 , pp. 25210-25215
    • Tse, S.M.1    Mason, D.2    Botelho, R.J.3    Chiu, B.4    Reyland, M.5    Hanada, K.6    Inman, R.D.7    Grinstein, S.8
  • 29
    • 0037151111 scopus 로고    scopus 로고
    • The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine 262 and is essential for maintaining plasma membrane sphingomyelin levels
    • van Tiel, C. M., J. Westerman, M. A. Paasman, M. M. Hoebens, K. W. Wirtz, and G. T. Snoek. 2002. The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine 262 and is essential for maintaining plasma membrane sphingomyelin levels. J. Biol. Chem. 277:22447-22452.
    • (2002) J. Biol. Chem , vol.277 , pp. 22447-22452
    • van Tiel, C.M.1    Westerman, J.2    Paasman, M.A.3    Hoebens, M.M.4    Wirtz, K.W.5    Snoek, G.T.6
  • 30
    • 33748490301 scopus 로고    scopus 로고
    • Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle
    • Wolf, K., H. J. Betts, B. Chellas-Gery, S. Hower, C. N. Linton, and K. A. Fields. 2006. Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle. Mol. Microbiol. 61:1543-1555.
    • (2006) Mol. Microbiol , vol.61 , pp. 1543-1555
    • Wolf, K.1    Betts, H.J.2    Chellas-Gery, B.3    Hower, S.4    Linton, C.N.5    Fields, K.A.6
  • 31
    • 33744964615 scopus 로고    scopus 로고
    • Dual specificity of the interfacial inhibitor brefeldin A for arf proteins and sec7 domains
    • Zeeh, J. C., M. Zeghouf, C. Grauffel, B. Guibert, E. Martin, A. Dejaegere, and J. Cherfils. 2006. Dual specificity of the interfacial inhibitor brefeldin A for arf proteins and sec7 domains. J. Biol. Chem. 281:11805-11814.
    • (2006) J. Biol. Chem , vol.281 , pp. 11805-11814
    • Zeeh, J.C.1    Zeghouf, M.2    Grauffel, C.3    Guibert, B.4    Martin, E.5    Dejaegere, A.6    Cherfils, J.7
  • 32
    • 34548101125 scopus 로고    scopus 로고
    • Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease
    • Zhang, D., V. Anantharam, A. Kanthasamy, and A. G. Kanthasamy. 2007. Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J. Pharmacol. Exp. Ther. 322: 913-922.
    • (2007) J. Pharmacol. Exp. Ther , vol.322 , pp. 913-922
    • Zhang, D.1    Anantharam, V.2    Kanthasamy, A.3    Kanthasamy, A.G.4
  • 33
    • 0036087717 scopus 로고    scopus 로고
    • Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCδ-independent fashion
    • Zhao, H., W. Tian, and D. M. Cohen. 2002. Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCδ-independent fashion. Am. J. Physiol. Renal Physiol. 282:F710-F717.
    • (2002) Am. J. Physiol. Renal Physiol , vol.282
    • Zhao, H.1    Tian, W.2    Cohen, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.