Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium

Journal of Biological Chemistry

Volumn 281, Issue 24, 2006, Pages 16691-16699

  Balakrishnan, Amit ^a,b   Patel, Bhairavi ^a   Sieber, Stephan A ^c   Chen, Ding ^d   Pachikara, Niseema ^a,b   Zhong, Guangming ^d   Cravatt, Benjamin F ^c   Fan, Huizhou ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLAMYDIA TRACHOMATIS; MOLECULAR PROBE; MUTATION; PEPTIDE DEFORMYLASE (PDF);

BACTERIA; BIOCHEMISTRY; CELLS; DISEASES; ENZYMES; MUTAGENESIS;

MOLECULAR BIOLOGY;

ACTINONIN; BACTERIAL ENZYME; ILOMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PEPTIDE DEFORMYLASE; TAPI 0; UNCLASSIFIED DRUG;

ARTICLE; CHLAMYDIA TRACHOMATIS; ENZYME ACTIVITY; GENE MUTATION; GROWTH INHIBITION; HOST CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

AMIDOHYDROLASES; CELL LINE, TUMOR; CHLAMYDIA TRACHOMATIS; CLONING, MOLECULAR; DIPEPTIDES; ENZYME INHIBITORS; HELA CELLS; HUMANS; HYDROXAMIC ACIDS; METALLOPROTEASES; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY;

BACTERIA (MICROORGANISMS); CHLAMYDIA TRACHOMATIS; CHLAMYDIAE;

EID: 33745188914     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513648200     Document Type: Article

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