Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection

Vaccine

Volumn 25, Issue 19, 2007, Pages 3773-3780

  Cong, Yu ^a   Jupelli, Madhulika ^a   Guentzel, M Neal ^a   Zhong, Guangming ^b   Murthy, Ashlesh K ^a   Arulanandam, Bernard P ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Adjuvant; Chlamydia; Chlamydial protease like activity factor; CPAF; CpG; Genital; Vaccine

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL VACCINE; CHLAMYDIAL PROTEASE LIKE ACTIVITY FACTOR; CHLAMYDIAL PROTEASE LIKE ACTIVITY FACTOR PLUS CPG OLIGODEOXYNUCLEOTIDE; CHLAMYDIAL PROTEASE LIKE ACTIVITY FACTOR PLUS OLIGODEOXYNUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE; DRUG VEHICLE; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; OLIGODEOXYNUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG FORMULATION; FEMALE; FEMALE GENITAL TRACT INFECTION; HUMAN; HUMAN CELL; HYDROSALPINX; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; CPG ISLANDS; ENDOPEPTIDASES; FEMALE; GENITAL DISEASES, FEMALE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN A, SECRETORY; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; VAGINA;

EID: 34247163593     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.02.010     Document Type: Article

References (42)

1. Morrison R.P., and Caldwell H.D. Immunity to murine chlamydial genital infection. Infect Immun 70 6 (2002) 2741-2751
2. Brunham R.C., and Rey-Ladino J. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat Rev Immunol 5 2 (2005) 149-161
3. Zhong G., Fan P., Ji H., Dong F., and Huang Y. Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J Exp Med 193 8 (2001) 935-942
4. Dong F., Su H., Huang Y., Zhong Y., and Zhong G. Cleavage of host keratin 8 by a Chlamydia-secreted protease. Infect Immun 72 7 (2004) 3863-3868
5. Pirbhai M., Dong F., Zhong Y., Pan K.Z., and Zhong G. The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells. J Biol Chem 281 42 (2006) 31495-31501
6. Murthy A.K., Chambers J.P., Meier P.A., Zhong G., and Arulanandam B.P. Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology and is highly dependent upon endogenous IFN-{gamma} production. Infect Immun (2006)
7. Murphey C., Murthy A.K., Meier P.A., Guentzel M.N., Zhong G., and Arulanandam B.P. The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4(+) T cells. Cell Immunol (2006)
8. Verthelyi D., and Klinman D.M. Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. Clin Immunol 109 1 (2003) 64-71
9. Weiner G.J. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J Leuk Biol 68 4 (2000) 455-463
10. Chu R.S., Targoni O.S., Krieg A.M., Lehmann P.V., and Harding C.V. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 186 10 (1997) 1623-1631
11. Roman M., Martin-Orozco E., Goodman J.S., Nguyen M.D., Sato Y., Ronaghy A., et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 3 8 (1997) 849-854
12. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 6522 (1995) 546-549
13. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20 (2002) 709-760
14. Verthelyi D. Adjuvant properties of CpG oligonucleotides in primates. Meth Mol Med 127 (2006) 139-158
15. Pal S., Davis H.L., Peterson E.M., and de la Maza L.M. Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein by use of CpG oligodeoxynucleotides as an adjuvant induces a protective immune response against an intranasal chlamydial challenge. Infect Immun 70 9 (2002) 4812-4817
16. Berry L.J., Hickey D.K., Skelding K.A., Bao S., Rendina A.M., Hansbro P.M., et al. Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect Immun 72 2 (2004) 1019-1028
17. Skelding K.A., Hickey D.K., Horvat J.C., Bao S., Roberts K.G., Finnie J.M., et al. Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection. Vaccine 24 3 (2006) 355-366
18. Meeusen E.N., Scheerlinck J.P., Wattegedera S., and Entrican G. Advances in mucosal vaccination. Anim Health Res Rev 5 2 (2004) 209-217
19. Lencer W.I. Mucosal vaccination: "all politics are local". Gastroenterology 116 2 (1999) 497-499
20. Walker R.I. New strategies for using mucosal vaccination to achieve more effective immunization. Vaccine 12 5 (1994) 387-400
21. Igietseme J.U., Uriri I.M., Kumar S.N., Ananaba G.A., Ojior O.O., Momodu I.A., et al. Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice. Infect Immun 66 9 (1998) 4030-4035
22. Murthy A.K., Sharma J., Coalson J.J., Zhong G., and Arulanandam B.P. Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice. Cell Immunol 230 1 (2004) 56-64
23. Dong F., Zhong Y., Arulanandam B., and Zhong G. Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species. Infect Immun 73 3 (2005) 1868-1872
24. Dong F., Pirbhai M., Zhong Y., and Zhong G. Cleavage-dependent activation of a Chlamydia-secreted protease. Mol Microbiol 52 5 (2004) 1487-1494
25. Wongratanacheewin S., Kespichayawattana W., Intachote P., Pichyangkul S., Sermswan R.W., Krieg A.M., et al. Immunostimulatory CpG oligodeoxynucleotide confers protection in a murine model of infection with Burkholderia pseudomallei. Infect Immun 72 8 (2004) 4494-4502
26. Gallichan W.S., Woolstencroft R.N., Guarasci T., McCluskie M.J., Davis H.L., and Rosenthal K.L. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J Immunol 166 5 (2001) 3451-3457
27. Murthy A.K., Cong Y., Murphey C., Guentzel M.N., Forsthuber T.G., Zhong G., et al. Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. Infect Immun 74 12 (2006) 6722-6729
28. Perry L.L., Feilzer K., and Caldwell H.D. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways. J Immunol 158 7 (1997) 3344-3352
29. Morrison S.G., Su H., Caldwell H.D., and Morrison R.P. Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cells. Infect Immun 68 12 (2000) 6979-6987
30. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect Immun 63 9 (1995) 3302-3308
31. Ito J.I., and Lyons J.M. Role of gamma interferon in controlling murine chlamydial genital tract infection. Infect Immun 67 10 (1999) 5518-5521
32. Cotter T.W., Ramsey K.H., Miranpuri G.S., Poulsen C.E., and Byrne G.I. Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect Immun 65 6 (1997) 2145-2152
33. Johansson M., Schon K., Ward M., and Lycke N. Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response. Infect Immun 65 3 (1997) 1032-1044
34. Rank R.G., Ramsey K.H., Pack E.A., and Williams D.M. Effect of gamma interferon on resolution of murine chlamydial genital infection. Infect Immun 60 10 (1992) 4427-4429
35. + T cells. Infect Immun 69 4 (2001) 2643-2649
36. Su H., Feilzer K., Caldwell H.D., and Morrison R.P. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect Immun 65 6 (1997) 1993-1999
37. Pal S., Theodor I., Peterson E.M., and de la Maza L.M. Monoclonal immunoglobulin A antibody to the major outer membrane protein of the Chlamydia trachomatis mouse pneumonitis biovar protects mice against a chlamydial genital challenge. Vaccine 15 5 (1997) 575-582
38. Moore T., Ekworomadu C.O., Eko F.O., MacMillan L., Ramey K., Ananaba G.A., et al. Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens. J Infect Dis 188 4 (2003) 617-624
39. Moore T., Ananaba G.A., Bolier J., Bowers S., Belay T., Eko F.O., et al. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology 105 2 (2002) 213-221
40. Sharma J., Bosnic A.M., Piper J.M., and Zhong G. Human antibody responses to a Chlamydia-secreted protease factor. Infect Immun 72 12 (2004) 7164-7171
41. Sharma J., Dong F., Pirbhai M., and Zhong G. Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis. Infect Immun 73 7 (2005) 4414-4419
42. Tokunaga T., Yamamoto H., Shimada S., Abe H., Fukuda T., Fujisawa Y., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 72 4 (1984) 955-962