Patho-physiology and dynamics of altered glucose metabolism in obese children and adolescents

International Journal of Pediatric Obesity

Volumn 3, Issue SUPPL.1, 2008, Pages 15-20

  Weiss, Ram ^a   Gillis, David ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Insulin resistane; Insulin secretion; Lipid partitioning; Obesity

Indexed keywords

GLUCAGON; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PROINSULIN;

ARTICLE; CHILDHOOD DISEASE; DIABETOGENESIS; EARLY INTERVENTION; GENETIC PREDISPOSITION; GENETIC RISK; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HEMOGLOBIN BLOOD LEVEL; HIGH RISK POPULATION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE MODIFICATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET ALPHA CELL; PATHOPHYSIOLOGY; PREVALENCE; PRIMARY PREVENTION; PRIORITY JOURNAL; RISK FACTOR; VULNERABLE POPULATION; WEIGHT GAIN;

ADOLESCENT; BLOOD GLUCOSE; CHILD; DIABETES MELLITUS, TYPE 2; GLUCOSE INTOLERANCE; HUMANS; INSULIN; INSULIN RESISTANCE; OBESITY;

EID: 39649083771     PISSN: 17477166     EISSN: 17477174     Source Type: Journal    
DOI: 10.1080/17477160801896499     Document Type: Article

References (38)

1. Kaufman, FR. (2005) Type 2 diabetes in children and youth. Endocrinol Metab Clin North Am., 34:3, pp. 659-676.
2. Rosenbloom, AL, Joe, JR, Young, RS and Winter, WE. (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care., 22:2, pp. 345-354.
3. Ehtisham, S., Barrett, TG and Shaw, NJ. (2000) Type 2 diabetes mellitus in UK children-an emerging problem. Diabet Med., 17:12, pp. 867-871.
4. Schober, E., Holl, RW, Grabert, M., Thon, A., Rami, B. and Kapellen, T. (2005) Diabetes mellitus type 2 in childhood and adolescence in Germany and parts of Austria. Eur J Pediatr., 164:11, pp. 705-707.
5. Smyth, S. and Heron, A. (2006) Diabetes and obesity: The twin epidemics. Nat Med., 12:1, pp. 75-80.
6. Kahn, SE, Prigeon, RL, McCulloch, DK, Boyko, EJ, Bergman, RN and Schwartz, MW (1993) Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes., 42:11, pp. 1663-1672.
7. Ahren, B. and Pacini, G. (2004) Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies. Eur J Endocrinol., 150:2, pp. 97-104.
8. Kahn, SE, Montgomery, B., Howell, W., Ligueros-Saylan, M., Hsu, CH and Devineni, D. (2001) Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab., 86:12, pp. 5824-5829.
9. Weiss, R., Dziura, JD, Burgert, TS, Taksali, SE, Tamborlane, WV and Caprio, S. (2006) Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia., 49:3, pp. 571-579.
10. Goran, MI and Gower, BA. (2001) Longitudinal study on pubertal insulin resistance. Diabetes., 50:11, pp. 2444-2450.
11. Saad, RJ, Danadian, K., Lewy, V. and Arslanian, SA. (2002) Insulin resistance of puberty in African-American children: Lack of a compensatory increase in insulin secretion. Pediatr Diabetes., 3:1, pp. 4-9.
12. Weiss, R., Dufour, S., Taksali, SE, Tamborlane, WV, Petersen, KF and Bonadonna, RC (2003) Prediabetes in obese youth: A syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet., 362:9388, pp. 951-957.
13. Gungor, N., Bacha, F., Saad, R., Janosky, J. and Arslanian, S. (2005) Youth type 2 diabetes: Insulin resistance, beta-cell failure, or both?. Diabetes Care., 28:3, pp. 638-644.
14. Weiss, R., Taksali, SE, Dufour, S., Yeckel, CW, Papademetris, X. and Cline, G. (2005) The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning. J Clin Endocrinol Metab., 90:6, pp. 3731-3737.
15. Bacha, F., Saad, R., Gungor, N., Janosky, J. and Arslanian, SA. (2003) Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: Race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab., 88:6, pp. 2534-2540.
16. Weiss, R., Caprio, S., Trombetta, M., Taksali, SE, Tamborlane, WV and Bonadonna, R. (2005) Beta-cell function across the spectrum of glucose tolerance in obese youth. Diabetes., 54:6, pp. 1735-1743.
17. Gungor, N., Bacha, F., Saad, R., Janosky, J. and Arslanian, S. (2005) Youth type 2 diabetes: Insulin resistance, beta-cell failure, or both?. Diabetes Care., 28:3, pp. 638-644.
18. Goran, MI, Bergman, RN, Avila, Q., Watkins, M., Ball, GD and Shaibi, GQ (2004) Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metab., 89:1, pp. 207-212.
19. Yeckel, CW, Taksali, SE, Dziura, J., Weiss, R., Burgert, TS and Sherwin, RS (2005) The normal glucose tolerance continuum in obese youth: evidence for impairment in beta-cell function independent of insulin resistance. J Clin Endocrinol Metab., 90:2, pp. 747-754.
20. Hanley, AJ, D'Agostino Jr, R., Wagenknecht, LE, Saad, MF, Savage, PJ and Bergman, R. (2002) Increased pro-insulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the Insulin Resistance Atherosclerosis Study. Diabetes., 51, pp. 1263-1270.
21. Kahn, SE, Leonetti, DL, Prigeon, RL, Boyko, EJ, Bergstom, RW and Fujimoto, WY. (1996) Proinsulin levels predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japanese-American men. Diabet Med., 13:9, p. S63.
22. Stumvoll, M., Fritsche, A., Stefan, N., Hardt, E. and Haring, H. (2001) Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction. J Clin Endocrinol Metab., 86, pp. 1235-1239.
23. Umpaichitra, V., Bastian, W., Taha, D., Banerji, MA, AvRuskin, TW and Castells, S. (2001) C-peptide and glucagon profiles in minority children with type 2 diabetes mellitus. J Clin Endocrinol Metab., 86:4, pp. 1605-1609.
24. Medici, F., Hawa, M., Ianari, A., Pyke, DA and Leslie, RD. (1999) Concordance rate for type II diabetes mellitus in monozygotic twins: actuarial analysis. Diabetologia., 42:2, pp. 146-150.
25. Petersen, KF, Dufour, S., Befroy, D., Garcia, R. and Shulman, GI. (2004) Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med., 350:7, pp. 664-671.
26. Befroy, DE, Petersen, KF, Dufour, S., Mason, GF, de Graaf, RA and Rothman, DL (2007) Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes., 56:5, pp. 1376-1381.
27. Elbein, SC, Hasstedt, SJ, Wegner, K. and Kahn, SE. (1999) Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. J Clin Endocrinol Metab., 84:4, pp. 1398-1403.
28. Dabelea, D., Pettitt, DJ, Jones, KL and Arslanian, SA. (1999) Type 2 diabetes mellitus in minority children and adolescents. An emerging problem. Endocrinol Metab Clin North Am., 28:4, pp. 709-729.
29. Frayling, TM. (2007) Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet., 8:9, pp. 657-662.
30. Frayling, TM, Timpson, NJ, Weedon, MN, Zeggini, E. and Freathy, RM (2007) Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science., 316:5826, pp. 889-894.
31. Zeggini, E., Weedon, MN, Lindgren, CM, Frayling, TM, Elliott, KS and Lango, H. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science., 316:5829, pp. 1336-1341.
32. Polonsky, KS, Sturis, J. and Bell, GI. (1996) Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med., 334, pp. 777-783.
33. Utzschneider, KM, Carr, DB, Hull, RL, Kodama, K., Shofer, JB and Retzlaff, BM (2004) Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function. Diabetes., 53:11, pp. 2867-2872.
34. Weiss, R., Taksali, SE, Tamborlane, WV, Burgert, TS, Savoye, M. and Caprio, S. (2005) Predictors of changes in glucose tolerance status in obese youth. Diabetes Care., 28:4, pp. 902-909.
35. Edelstein, SL, Knowler, WC, Bain, RP, Andres, R., Barrett-Connor, EL and Dowse, GK (1997) Predictors of progression from impaired glucose tolerance to NIDDM: An analysis of six prospective studies. Diabetes., 46, pp. 701-710.
36. Saad, MF, Knowler, WC, Pettitt, DJ, Nelson, RG, Mott, DM and Bennett, PH (1988) The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med, 319, pp. 1500-1506.
37. Knowler, WC, Barrett-Connor, E., Fowler, SE, Hamman, RF, Lachin, JM and Walker, EA (2002) Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med., 346:6, pp. 393-403.
38. Weiss, R., Cali, AM, Dziura, J., Burgert, TS, Tamborlane, WV and Caprio, S. (2007) Degree of obesity and glucose allostasis are major effectors of glucose tolerance dynamics in obese youth. Diabetes Care., 30:7, pp. 1845-1850.