Youth type 2 diabetes: Insulin resistance, β-cell failure, or both?

Diabetes Care

Volumn 28, Issue 3, 2005, Pages 638-644

  Gungor, Neslihan ^a   Bacha, Fida ^a   Saad, Rola ^a   Janosky, Janine ^b   Arslanian, Silva ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADOLESCENT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DETERIORATION; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS FUNCTION; PANCREAS INSUFFICIENCY; PANCREAS ISLET BETA CELL;

ADIPONECTIN; ADOLESCENT; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MALE; OBESITY;

EID: 14644432432     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.28.3.638     Document Type: Article

References (25)

1. American Diabetes Association: Type 2 diabetes in children and adolescents. Diabetes Care 23:381-389, 2000
2. Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Charles MA, Bennett PH: A two-step model for development of non-insulin-dependent diabetes. Am J Med 90:229-235, 1991
3. Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794, 1999
4. Kahn SE: The importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86:4047-4058, 2001
5. Banerji MA, Lebovitz HE: Insulin action in black Americans with NIDDM. Diabetes Care 15:1295-1302, 1992
6. Bacha F, Saad R, Gungor N, Janosky J, Arslanian SA: Obesity, regional fat distribution and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 88:2534-2540, 2003
7. Bacha F, Saad R, Gungor N, Arslanian S: Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and β-cell function. Diabetes Care 27:547-552, 2004
8. Tanner JM: Growth and maturation during adolescence. Nutr Rev 39:43-55, 1981
9. Gungor N, Saad R, Janosky J, Arslanian S: Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 144: 47-55, 2004
10. Danadian K, Balasekaran G, Lewy V, Meza MP, Robertson R, Arslanian SA: Insulin sensitivity in African-American children with and without family history of type 2 diabetes. Diabetes Care 22:1325-1329, 1999
11. Arslanian SA, Lewy VD, Danadian K: Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab 86:66-71, 2001
12. Arslanian S, Suprasongsin C: Glucose-fatty acid interactions in prepubertal and pubertal children: effects of lipid infusion. Am J Physiol 272:E523-E529, 1997
13. Lewy VD, Danadian K, Witchel SF, Arslanian SA: Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome. J Pediatr 138:38-44, 2001
14. Kobayashi K, Amemiya S, Higashida K, Ishihara T, Sawanobori E, Kobayashi K, Mochizuki M, Kikuchi N, Tokuyama K, Nakazawa S: Pathogenic factors of glucose intolerance in obese Japanese adolescents with type 2 diabetes. Metabolism 49:186-191, 2000
15. Haffner SM, Stern MP, Mitchell BD, Hazuda HP, Patterson JK: Incidence of type II diabetes in Mexican-Americans predicted by fasting insulin and glucose levels, obesity and body fat distribution. Diabetes 39:283-288, 1990
16. Lillioja S, Mott D, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 329:1988-1992, 1993
17. Tripathy D, Carlsson M, Almgren P, Isomaa B, Taskinen MR, Tuomi T, Groop LC: Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes 49:975-980, 2000
18. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599, 2000
19. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA: Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935, 2001
20. Umpaichitra V, Bastian W, Taha D, Banerji MA, AvRuskin TW, Castells S: C-peptide and glucagon profiles in minority children with type 2 diabetes mellitus. J Clin Endocrinol Metab 86:1605-1609, 2001
21. Roder ME, Dinesen B, Hartling SG, Houssa P, Vestergaard H, Sodoyez-Goffaux F, Binder C: Intact proinsulin and β-cell function in lean and obese subjects with and without type 2 diabetes. Diabetes Care 22:609-614, 1999
22. Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC: UKPDS 26: sulfonylurea failure in non-insulin dependent diabetic patients over six years: UK Prospective Diabetes Study (UKPDS) Group. Diabet Med 15:297-303, 1998
23. Holman RR: Assessing the potential for alpha-glucosidase inhibitors in prediabetic states. Diabetes Res Clin Pract 40: S21-S25, 1998
24. Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR: Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med 15: 290-296, 1998
25. Gungor N, Arslanian S: Progressive beta cell failure in type 2 diabetes mellitus of youth. J Pediatr 144:656-659, 2004