Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 4, 2008, Pages 1158-1163

  Kale, Sachin ^a   Ulas, Gözde ^c   Song, Jaeyoung ^a   Brudvig, Gary W ^c   Furey, William ^b   Jordan, Frank ^a  

^a Rutgers University   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Coupling of dynamics to catalysis; EPR; Mobile loop dynamics; NMR; Pyruvate dehydrogenase

Indexed keywords

PYRUVATE DEHYDROGENASE COMPLEX; ESCHERICHIA COLI PROTEIN; LIGAND; PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX E1; UNCLASSIFIED DRUG;

CARBOHYDRATE METABOLISM; CARBOXYLATION; CATALYSIS; CONFERENCE PAPER; COVALENT BOND; ENTROPY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; HIGH TEMPERATURE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; THERMODYNAMICS; VISCOSITY; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHEMISTRY; CIRCULAR DICHROISM; ELECTRON SPIN RESONANCE; GENETICS; KINETICS; METABOLISM; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

ESCHERICHIA COLI;

AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; CIRCULAR DICHROISM; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI PROTEINS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PYRUVATE DEHYDROGENASE COMPLEX; SUBSTRATE SPECIFICITY; THERMODYNAMICS; VISCOSITY;

EID: 39549122002     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709328105     Document Type: Article

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