The interplay of osteogenesis and hematopoiesis: Expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow

Journal of Cell Biology

Volumn 167, Issue 6, 2004, Pages 1113-1122

  Kuznetsov, Sergei A ^a   Riminucci, Mara ^b,c   Ziran, Navid ^a,f   Tsutsui, Takeo W ^a,g   Corsi, Alessandro ^d   Calvi, Laura ^e,h   Kronenberg, Henry M ^e   Schipani, Ernestina ^e   Robey, Pamela Gehron ^a   Bianco, Paolo ^a,c,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c Biomedical Science Park San Raffaele   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^g NIPPON DENTAL UNIVERSITY   (Japan)

^h STRONG MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN RECEPTOR;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE MARROW; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; HEMATOPOIESIS; IN VITRO STUDY; MESENCHYME; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; ONTOGENY; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL;

ANIMALS; BONE AND BONES; BONE MARROW; CELLS, CULTURED; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; MALE; MICE; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOGENESIS; PARATHYROID HORMONE; PHENOTYPE; RECEPTOR, PARATHYROID HORMONE, TYPE 1; STEM CELLS;

ANIMALIA;

EID: 19944426754     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200408079     Document Type: Article

References (42)

1. Begley, C.T., M.J. Doherty, D.P. Hankey, and D.J. Wilson. 1993. The culture of human osteoblasts upon bone graft substitutes. Bone. 14:661-666.
2. Bianco, P., and E. Bonucci. 1991. Endosteal surfaces in hyperparathyroidism: an enzyme cytochemical study on low-temperature-processed, glycolmethacrylate-embedded bone biopsies. Virchows Arch. A Pathol. Anat. Histopathol. 419:425-431.
3. Bianco, P., and A. Boyde. 1993. Confocal images of marrow stromal (Westen-Bainton) cells. Histochemistry. 100:93-99.
4. Bianco, P., and M. Riminucci. 1998. The bone marrow stroma in vivo: ontogeny, structure, cellular composition and changes in disease. In Marrow Stromal Cell Culture. M.A. Owen and J.N. Beresford, editors. Cambridge University Press, Cambridge, UK. 10-25.
5. Bianco, P., and P. Robey. 1999. Diseases of bone and the stromal cell lineage. J. Bone Miner. Res. 14:336-341.
6. Bianco, P., and P.G. Robey. 2000. Marrow stromal stem cells. J. Clin. Invest. 105:1663-1668.
7. Bianco, P., and P.G. Robey. 2004. Skeletal stem cells. In Handbook of Adult Stem Cells. R. Lanza, editor. Elsevier Acedemic Press. San Diego. 415-424.
8. Bianco, P., Y. Hayashi, G. Silvestrini, J.D. Termine, and E. Bonucci. 1985. Osteonectin and Gla-protein in calf bone: ultrastructural immunohistochemical localization using the Protein A-gold method. Calcif. Tissue Int. 37:684-686.
9. Bianco, P., M. Costantini, L.C. Dearden, and E. Bonucci. 1988. Alkaline phosphatase positive precursors of adipocytes in the human bone marrow. Br. J. Haematol. 68:401-403.
10. Bianco, P., S.A. Kuznetsov, M. Riminucci, L.W. Fisher, A.M. Spiegel, and P.G. Robey. 1998. Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gs alpha-mutated skeletal progenitor cells. J. Clin. Invest. 101:1737-1744.
11. Bianco, P., M. Riminucci, S. Kuznetsov, and P.G. Robey. 1999. Multipotential cells in the bone marrow stroma: regulation in the context of organ physiology. Crit. Rev. Eukaryot. Gene Expr. 9:159-173.
12. Bradbeer, J.N., M. Riminucci, and P. Bianco. 1994. Giemsa as a fluorescent stain for mineralized bone. J. Histochem. Cytochem. 42:677-680.
13. Calvi, L.M., N.A. Sims, J.L. Hunzelman, M.C. Knight, A. Giovannetti, J.M. Saxton, H.M. Kronenberg, R. Baron, and E. Schipani. 2001. Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J. Clin. Invest. 107:277-286.
14. Calvi, L.M., G.B. Adams, K.W. Weibrecht, J.M. Weber, D.P. Olson, M.C. Knight, R.P. Martin, E. Schipani, P. Divieti, F.R. Bringhurst, et al. 2003. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 425:841-846.
15. Chailakhyan, R.K., U.V. Gerasimov, and A.J. Friedenstein. 1978. Transfer of bone marrow microenvironment by clones of stromal mechanocytes. Bull. Exp. Biol. Med. 86:1633-1635.
16. Corsi, A., M.T. Collins, M. Riminucci, P.G. Howell, A. Boyde, P.G. Robey, and P. Bianco. 2003. Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations. J. Bone Miner. Res. 18:1235-1246.
17. Damien, C.J., and J.R. Parsons. 1991. Bone graft and bone graft substitutes: a review of current technology and applications. J. Appl. Biomater. 2:187-208.
18. de Crombrugghe, B., V. Lefebvre, and K. Nakashima. 2001. Regulatory mechanisms in the pathways of cartilage and bone formation. Curr. Opin. Cell Biol. 13:721-727.
19. Friedenstein, A.J. 1980. Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo. Hamatol. Bluttransfus. 25:19-29.
20. Friedenstein, A.J. 1990. Bone marrow osteogenic stem cells. In Calcium Regulation and Bone Metabolism. D.V. Cohn, F.H. Glorieux, and T.J. Martin, editors. Elsevier, Cambridge, UK. 353-361.
21. Friedenstein, A.J., R.K. Chailakhyan, N.V. Latsinik, A.F. Panasyuk, and I.V. Keiliss-Borok. 1974. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 17:331-340.
22. Holmbeck, K., P. Bianco, J. Caterina, S. Yamada, M. Kromer, S.A. Kuznetsov, M. Mankani, P.G. Robey, A.R. Poole, I. Pidoux, et al. 1999. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell. 99:81-92.
23. Karaplis, A.C., A. Luz, J. Glowacki, R.T. Bronson, V.L. Tybulewicz, H.M. Kronenberg, and R.C. Mulligan. 1994. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8:277-289.
24. Krebsbach, P.H., S.A. Kuznetsov, K. Satomura, R.V. Emmons, D.W. Rowe, and P.G. Robey. 1997. Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation. 63:1059-1069.
25. Kuznetsov, S., and P. Gehron Robey. 1996. Species differences in growth requirements for bone marrow stromal fibroblast colony formation in vitro. Calcif. Tissue Int. 59:265-270.
26. Kuznetsov, S.A., P.H. Krebsbach, K. Satomura, J. Kerr, M. Riminucci, D. Benayahu, and P.G. Robey. 1997. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J. Bone Miner. Res. 12:1335-1347.
27. Lanske, B., A.C. Karaplis, K. Lee, A. Luz, A. Vortkamp, A. Pirro, M. Karperien, L.H. Defize, C. Ho, R.C. Mulligan, et al. 1996. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 273:663-666.
28. Lee, K., J.D. Deeds, A.T. Bond, H. Juppner, A.B. Abou-Samra, and G.V. Segre. 1993. In situ localization of PTH/PTHrP receptor mRNA in the bone of fetal and young rats. Bone. 14:341-345.
29. Lee, K., J.D. Deeds, S. Chiba, M. Un-No, A.T. Bond, and G.V. Segre. 1994. Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids. Endocrinology. 134:441-450.
30. Morrison, S.J., N. Uchida, and I.L. Weissman. 1995. The biology of hematopoietic stem cells. Annu. Rev. Cell Dev. Biol. 11:35-71.
31. Owen, M., and A.J. Friedenstein. 1988. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found. Symp. 136:42-60.
32. Riminucci, M., L.W. Fisher, A. Shenker, A.M. Spiegel, P. Bianco, and P. Gehron Robey. 1997. Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. Am. J. Pathol. 151:1587-1600.
33. Riminucci, M., B. Liu, A. Corsi, A. Shenker, A.M. Spiegel, P.G. Robey, and P. Bianco. 1999. The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gsa gene: site-specific patterns and recurrent histological hallmarks. J. Pathol. 187:249-258.
34. Satomura, K., P. Krebsbach, P. Bianco, and P. Gehron Robey. 2000. Osteogenic imprinting upstream of marrow stromal cell differentiation. J. Cell. Biochem. 78:391-403.
35. Schipani, E., K. Kruse, and H. Juppner. 1995. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science. 268:98-100.
36. Schipani, E., C.B. Langman, A.M. Parfitt, G.S. Jensen, S. Kikuchi, S.W. Kooh, W.G. Cole, and H. Juppner. 1996. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. N. Engl. J. Med. 335:708-714.
37. Schipani, E., B. Lanske, J. Hunzelman, A. Luz, C.S. Kovacs, K. Lee, A. Pirro, H.M. Kronenberg, and H. Juppner. 1997. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc. Natl. Acad. Sci. USA. 94:13689-13694.
38. Sherley, J.L. 2002. Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture. Stem Cells. 20:561-572.
39. Streeter, G. 1949. Developmental horizons in human embryos. Contributions to Embryology. 33:151-167.
40. Tavassoli, M., and J.M. Yoffey. 1983. Bone Marrow: Structure and Function. Alan R. Liss, Inc., New York. 300 pp.
41. Watt, F.M., and B.L. Hogan. 2000. Out of eden: stem cells and their niches. Science. 287:1427-1430.
42. Westen, H., and D.F. Bainton. 1979. Association of alkaline-phosphatase- positive reticulum cells in bone marrow with granulocytic precursors. J. Exp. Med. 150:919-937.