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Volumn 1043, Issue , 2005, Pages 793-806

Post-Amadori AGE inhibition as a therapeutic target for diabetic complications: A rational approach to second-generation Amadorin design

Author keywords

Amadori; Aminoguanidine; BST 4997; AGE inhibitors; Fructosyllysine; Pimagedine; Pyridorin; Pyridoxamine; Rational drug design

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT INHIBITOR; AMADORIN; AMINOGUANIDINE; ANTIOXIDANT; BST 4997; CARBOXYMETHYLLYSINE; FRUCTOSYLLYSINE; LYSINE DERIVATIVE; PYRIDORIN; PYRIDOXAMINE; UNCLASSIFIED DRUG;

EID: 23744516038     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1333.092     Document Type: Conference Paper
Times cited : (41)

References (41)
  • 1
    • 0142026785 scopus 로고    scopus 로고
    • Intervention against the Maillard reaction in vivo
    • MONNIER, V.M. 2003. Intervention against the Maillard reaction in vivo. Arch. Biochem. Biophys. 419: 1-15.
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 1-15
    • Monnier, V.M.1
  • 2
    • 0028826628 scopus 로고
    • Pathways of formation of glycoxidation products during glycation of collagen
    • WELLS-KNECHT, M.C., S.R. THORPE & J.W. BAYNES. 1995. Pathways of formation of glycoxidation products during glycation of collagen. Biochemistry 34: 15134-15141.
    • (1995) Biochemistry , vol.34 , pp. 15134-15141
    • Wells-Knecht, M.C.1    Thorpe, S.R.2    Baynes, J.W.3
  • 4
    • 0022644227 scopus 로고
    • Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
    • BROWNLEE, M., H. VLASSARA, A. KOONEY, et al. 1986. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 232: 1629-1632.
    • (1986) Science , vol.232 , pp. 1629-1632
    • Brownlee, M.1    Vlassara, H.2    Kooney, A.3
  • 5
    • 10744223527 scopus 로고    scopus 로고
    • Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy
    • BOLTON, W.K., D.C. CATTRAN, M.E. WILLIAMS, et al. 2004. Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am. J. Nephrol. 24: 32-40.
    • (2004) Am. J. Nephrol. , vol.24 , pp. 32-40
    • Bolton, W.K.1    Cattran, D.C.2    Williams, M.E.3
  • 6
    • 0029995384 scopus 로고    scopus 로고
    • Kinetics of nonenzymatic glycation of ribonuclease a leading to advanced glycation end products. Paradoxical inhibition by ribose leads to facile isolation of protein intermediate for rapid post-Amadori studies
    • KHALIFAH, R.G., P. TODD, A.A. BOOTH, et al. 1996. Kinetics of nonenzymatic glycation of ribonuclease A leading to advanced glycation end products. Paradoxical inhibition by ribose leads to facile isolation of protein intermediate for rapid post-Amadori studies. Biochemistry 35: 4645-4654.
    • (1996) Biochemistry , vol.35 , pp. 4645-4654
    • Khalifah, R.G.1    Todd, P.2    Booth, A.A.3
  • 7
    • 0031054249 scopus 로고    scopus 로고
    • In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways
    • BOOTH, A.A., R.G. KHALIFAH, P. TODD & B.G. HUDSON. 1997. In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways. J. Biol. Chem. 272: 5430-5437.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5430-5437
    • Booth, A.A.1    Khalifah, R.G.2    Todd, P.3    Hudson, B.G.4
  • 8
    • 12144263911 scopus 로고    scopus 로고
    • A phase 2 clinical trial of pyridoxamine (Pyridorin™) in type 1 and type 2 diabetic patients with overt nephropathy (PYR-206)
    • WILLIAMS, M.E., W.K. BOLTON, T.P. DEGENHARDT & R. SCHOTZINGER. 2003. A phase 2 clinical trial of pyridoxamine (Pyridorin™) in type 1 and type 2 diabetic patients with overt nephropathy (PYR-206)(Abstr.). J. Am. Soc. Nephrol. 14: 7A.
    • (2003) J. Am. Soc. Nephrol. , vol.14
    • Williams, M.E.1    Bolton, W.K.2    Degenhardt, T.P.3    Schotzinger, R.4
  • 9
    • 17644387061 scopus 로고    scopus 로고
    • Investigation of the safety and efficacy of pyridoxamine (Pyridorin™) in patients with diabetic nephropathy (PYR-206)
    • BELL, D.S.H., T.P. DEGENHARDT, J.R. SZABO, et al. 2004. Investigation of the safety and efficacy of pyridoxamine (Pyridorin™) in patients with diabetic nephropathy (PYR-206) (Abstr.). Diabetes 53(Suppl. 2): A119.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Bell, D.S.H.1    Degenhardt, T.P.2    Szabo, J.R.3
  • 10
    • 17644367039 scopus 로고    scopus 로고
    • A phase 2 clinical investigation of pyridoxamine (Pyridorin™) in type 1 and type 2 diabetic patients with overt diabetic nephropathy (PYR-205/207)
    • MCGILL, J.B., T.P. DEGENHARDT, J.R. SZABO, et al. 2004. A phase 2 clinical investigation of pyridoxamine (Pyridorin™) in type 1 and type 2 diabetic patients with overt diabetic nephropathy (PYR-205/207) (Abstr.). Diabetes 53(Suppl. 2): A138.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • McGill, J.B.1    Degenhardt, T.P.2    Szabo, J.R.3
  • 11
    • 0036183727 scopus 로고    scopus 로고
    • Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat
    • DEGENHARDT, T.P., N.L. ALDERSON, D.D. ARRINGTON, et al. 2002. Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat. Kidney Int. 61: 939-950.
    • (2002) Kidney Int. , vol.61 , pp. 939-950
    • Degenhardt, T.P.1    Alderson, N.L.2    Arrington, D.D.3
  • 12
    • 0036723821 scopus 로고    scopus 로고
    • The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes
    • STITT, A., T.A. GARDINER, N.L. ALDERSON, et al. 2002. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes 51: 2826-2832.
    • (2002) Diabetes , vol.51 , pp. 2826-2832
    • Stitt, A.1    Gardiner, T.A.2    Alderson, N.L.3
  • 13
    • 3142530474 scopus 로고    scopus 로고
    • Decreased mortality and albuminuria following pyridoxamine and enalapril therapy in an obese mouse model of type 2 diabetes mellitus with established nephropathy
    • LECLERCQ, B., F. ZHENG, M. BERHO, et al. 2003. Decreased mortality and albuminuria following pyridoxamine and enalapril therapy in an obese mouse model of type 2 diabetes mellitus with established nephropathy (Abstr.). J. Am. Soc. Nephrol. 14: 396A.
    • (2003) J. Am. Soc. Nephrol. , vol.14
    • Leclercq, B.1    Zheng, F.2    Berho, M.3
  • 14
    • 13844315544 scopus 로고    scopus 로고
    • Pyridoxamine treatment improves nerve function in diabetic rats
    • CAMERON, N., M. COTTER, N. ALDERSON, et al. 2003. Pyridoxamine treatment improves nerve function in diabetic rats (Abstr.). Diabetes 52(Suppl. 1): A192.
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Cameron, N.1    Cotter, M.2    Alderson, N.3
  • 15
    • 0033551042 scopus 로고    scopus 로고
    • Amadorins: Novel post-Amadori inhibitors of advanced glycation reactions
    • KHALIFAH, R.G., J.W. BAYNES & B.G. HUDSON. 1999. Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Biochem. Biophys. Res. Commun. 257: 251-258.
    • (1999) Biochem. Biophys. Res. Commun. , vol.257 , pp. 251-258
    • Khalifah, R.G.1    Baynes, J.W.2    Hudson, B.G.3
  • 16
    • 75549096787 scopus 로고
    • Chemistry of nonenzymic browning. I. The reaction between aldoses and amines
    • REYNOLDS, T.M. 1963. Chemistry of nonenzymic browning. I. The reaction between aldoses and amines. Adv. Food Sci. 12: 1-52.
    • (1963) Adv. Food Sci. , vol.12 , pp. 1-52
    • Reynolds, T.M.1
  • 17
    • 0142044013 scopus 로고    scopus 로고
    • Role of lipids in chemical modification of proteins and development of complications in diabetes
    • JANUSZEWSKI, A.S., N.L. ALDERSON, T.O. METZ, et al. 2003. Role of lipids in chemical modification of proteins and development of complications in diabetes. Biochem. Soc. Trans. 31: 1413-1416.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1413-1416
    • Januszewski, A.S.1    Alderson, N.L.2    Metz, T.O.3
  • 18
    • 0029174019 scopus 로고
    • Formation of methylglyoxal-modified proteins in vitro and in vivo and their involvement in AGE-related processes
    • THORNALLEY, P.J., M. WESTWOOD, T.W. LO & A.C. MCLELLAN. 1995. Formation of methylglyoxal-modified proteins in vitro and in vivo and their involvement in AGE-related processes. Contrib. Nephrol. 112: 24-31.
    • (1995) Contrib. Nephrol. , vol.112 , pp. 24-31
    • Thornalley, P.J.1    Westwood, M.2    Lo, T.W.3    McLellan, A.C.4
  • 19
    • 0033571012 scopus 로고    scopus 로고
    • Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
    • THORNALLEY, P.J., A. LANGBORG & H.S. MINHAS. 1999. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem. J. 344: 109-116.
    • (1999) Biochem. J. , vol.344 , pp. 109-116
    • Thornalley, P.J.1    Langborg, A.2    Minhas, H.S.3
  • 20
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • BROWNLEE, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 21
    • 21144460354 scopus 로고
    • Mechanism of inhibition of advanced glycosylation by aminoguanidine in vitro
    • CHEN, H.J. & A. CERAMI. 1993. Mechanism of inhibition of advanced glycosylation by aminoguanidine in vitro. J. Carbohyd. Res. 12: 731-742.
    • (1993) J. Carbohyd. Res. , vol.12 , pp. 731-742
    • Chen, H.J.1    Cerami, A.2
  • 22
    • 0142074864 scopus 로고    scopus 로고
    • Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts
    • THORNALLEY, P.J. 2003. Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch. Biochem. Biophys. 419: 31-40.
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 31-40
    • Thornalley, P.J.1
  • 23
    • 0028223128 scopus 로고
    • Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction
    • FU, M.X., K.J. WELLS-KNECHT, J.A. BLACKLEDGE, et al. 1994. Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction. Diabetes 43: 676-683.
    • (1994) Diabetes , vol.43 , pp. 676-683
    • Fu, M.X.1    Wells-Knecht, K.J.2    Blackledge, J.A.3
  • 24
    • 0028934990 scopus 로고
    • Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction
    • GLOMB, M.A. & V.M. MONNIER. 1995. Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction. J. Biol. Chem. 270: 10017-10026.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10017-10026
    • Glomb, M.A.1    Monnier, V.M.2
  • 25
    • 0019475899 scopus 로고
    • Nonenzymatic browning in vivo: Possible process for aging of long-lived proteins
    • MONNIER, V.M. & A. CERAMI. 1981. Nonenzymatic browning in vivo: possible process for aging of long-lived proteins. Science 211: 491-493.
    • (1981) Science , vol.211 , pp. 491-493
    • Monnier, V.M.1    Cerami, A.2
  • 26
    • 0019741584 scopus 로고
    • Maillard reactions involving proteins and carbohydrates in vivo: Relevance to diabetes mellitus and aging
    • MONNIER, V.M., V.J. STEVENS & A. CERAMI. 1981. Maillard reactions involving proteins and carbohydrates in vivo: relevance to diabetes mellitus and aging. Prog. Food Nutr. Sci. 5: 315-327.
    • (1981) Prog. Food Nutr. Sci. , vol.5 , pp. 315-327
    • Monnier, V.M.1    Stevens, V.J.2    Cerami, A.3
  • 27
    • 0028979597 scopus 로고
    • N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins
    • REDDY, S., J. BICHLER, K.J. WELLS-KNECHT, et al. 1995. N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins. Biochemistry 34: 10872-10878.
    • (1995) Biochemistry , vol.34 , pp. 10872-10878
    • Reddy, S.1    Bichler, J.2    Wells-Knecht, K.J.3
  • 28
    • 0344443743 scopus 로고    scopus 로고
    • Modification of proteins in vitro by physiological levels of glucose: Pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions
    • VOZIYAN, P.A., R.G. KHALIFAH, C. THIBAUDEAU, et al. 2003. Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions. J. Biol. Chem. 278: 46616-46624.
    • (2003) J. Biol. Chem. , vol.278 , pp. 46616-46624
    • Voziyan, P.A.1    Khalifah, R.G.2    Thibaudeau, C.3
  • 29
    • 0036479252 scopus 로고    scopus 로고
    • A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation
    • VOZIYAN, P.A., T.O. METZ, J.W. BAYNES & B.G. HUDSON. 2002. A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. J. Biol. Chem. 277: 3397-3403.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3397-3403
    • Voziyan, P.A.1    Metz, T.O.2    Baynes, J.W.3    Hudson, B.G.4
  • 30
    • 0036612722 scopus 로고    scopus 로고
    • Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: Characterization of a major product from the reaction of pyridoxamine and methylglyoxal
    • NAGARAJ, R.H., P. SARKAR, A. MALLY, et al. 2002. Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. Arch. Biochem. Biophys. 402: 110-119.
    • (2002) Arch. Biochem. Biophys. , vol.402 , pp. 110-119
    • Nagaraj, R.H.1    Sarkar, P.2    Mally, A.3
  • 31
    • 4544349321 scopus 로고    scopus 로고
    • Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat
    • ALDERSON, N.L., M.E. CHACHICH, N. FRIZZELL, et al. 2004. Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat. Diabetologia 47: 1385-1395.
    • (2004) Diabetologia , vol.47 , pp. 1385-1395
    • Alderson, N.L.1    Chachich, M.E.2    Frizzell, N.3
  • 32
    • 0142058743 scopus 로고    scopus 로고
    • Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: A novel therapy for treatment of diabetic complications
    • METZ, T.O., N.L. ALDERSON, S.R. THORPE & J.W. BAYNES. 2003. Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications. Arch. Biochem. Biophys. 419: 41-49.
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 41-49
    • Metz, T.O.1    Alderson, N.L.2    Thorpe, S.R.3    Baynes, J.W.4
  • 33
    • 0023259759 scopus 로고
    • Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes
    • WOLFF, S.P. & R.T. DEAN. 1987. Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes. Biochem. J. 245: 243-250.
    • (1987) Biochem. J. , vol.245 , pp. 243-250
    • Wolff, S.P.1    Dean, R.T.2
  • 34
    • 0028951461 scopus 로고
    • Mechanism of autoxidative glycosylation: Identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose
    • WELLS-KNECHT, K.J., D.V. ZYZAK, J.E. LITCHFIELD, et al. 1995. Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose. Biochemistry 34: 3702-3709.
    • (1995) Biochemistry , vol.34 , pp. 3702-3709
    • Wells-Knecht, K.J.1    Zyzak, D.V.2    Litchfield, J.E.3
  • 35
    • 0028798704 scopus 로고
    • Formation of reactive intermediates from Amadori compounds under physiological conditions
    • ZYZAK, D.V., J.M. RICHARDSON, S.R. THORPE & J.W. BAYNES. 1995. Formation of reactive intermediates from Amadori compounds under physiological conditions. Arch. Biochem. Biophys. 316: 547-554.
    • (1995) Arch. Biochem. Biophys. , vol.316 , pp. 547-554
    • Zyzak, D.V.1    Richardson, J.M.2    Thorpe, S.R.3    Baynes, J.W.4
  • 37
    • 0348049818 scopus 로고    scopus 로고
    • The enzymatic defence against glycation in health, disease and therapeutics: A symposium to examine the concept
    • THORNALLEY, P.J. 2003. The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the concept. Biochem. Soc. Trans. 31: 1341-1342.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1341-1342
    • Thornalley, P.J.1
  • 38
    • 0242401999 scopus 로고    scopus 로고
    • Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease
    • BROCK, J.W., D.J. HINTON, W.E. COTHAM, et al. 2003. Proteomic analysis of the site specificity of glycation and carboxymethylation of ribonuclease. J. Proteome Res. 2: 506-513.
    • (2003) J. Proteome Res. , vol.2 , pp. 506-513
    • Brock, J.W.1    Hinton, D.J.2    Cotham, W.E.3
  • 39
    • 0016260535 scopus 로고
    • Interactions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systems
    • SUNDBERG, R.J. & R.B. MARTIN. 1974. Interactions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systems. Chem. Rev. 74: 471-517.
    • (1974) Chem. Rev. , vol.74 , pp. 471-517
    • Sundberg, R.J.1    Martin, R.B.2
  • 40
    • 33645173910 scopus 로고    scopus 로고
    • Skin collagen glycation products predict the progression risk of diabetic retinopathy and nephropathy in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)
    • SIVITZ, W., O. BAUTISTA, P.A. CLEARY, et al. 2004. Skin collagen glycation products predict the progression risk of diabetic retinopathy and nephropathy in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)(Abstr.). Diabetes 53(Suppl. 2): A58.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Sivitz, W.1    Bautista, O.2    Cleary, P.A.3
  • 41
    • 33645173798 scopus 로고    scopus 로고
    • Correction of neurovascular dysfunction in diabetic rats by the novel non-nucleophilic advanced glycation inhibitor, BST4997
    • CAMERON, N.E., M.A. COTTER, Y. CHEN & R. KHALIFAH. 2004. Correction of neurovascular dysfunction in diabetic rats by the novel non-nucleophilic advanced glycation inhibitor, BST4997 (Abstr.). Diabetes 53(Suppl. 2): A209.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Cameron, N.E.1    Cotter, M.A.2    Chen, Y.3    Khalifah, R.4


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