Umbilical Cord Blood Stem Cells: Collection, Processing, and Transplantation

Blood Banking and Transfusion Medicine

Volumn , Issue , 2007, Pages 823-832

  Broxmeyer, Hal E ^a,b  

^a Mary Margaret Walther   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 39449125123     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-443-06981-9.50064-8     Document Type: Chapter

References (129)

1. Gluckman E, Broxmeyer HE, Auerbach AD, et al. Hematopoietic reconsti-tution in a patient with Fanconi anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989, 321:1174-1178.
2. Broxmeyer HE, Douglas GW, Hangoc G, et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 1989, 86:3828-3832.
3. Broxmeyer HE, Gluckman E, Auerbach A, et al. Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/ progenitor cells. Int J Cell Cloning 1990, 8:76-91.
4. Broxmeyer HE Introduction: The past, present, and future of cord blood transplantation. Cellular Characteristics of Cord Blood and Cord Blood Transplantation 1998, 1-9. American Association of Blood Banks Press, Bethesda, Md. H.E. Broxmeyer (Ed.).
5. Broxmeyer HE Introduction: Cord blood transplantation: looking back and to the future. Cord Blood Characteristics: Role in Stem Cell Transplantation 2000, 1-12. Martin Dunitz, London. S.B.A. Cohen, E. Gluckman, P. Rubinstein (Eds.).
6. Gluckman E, Rocha V History of the clinical use of umbilical cord blood hematopoietic cells. Cytotherapy 2005, 7:219-227.
7. Wagner JE, Kernan NA, Steinbuch M, et al. Allogeneic sibling umbilical cord blood transplantation in forty-four children with malignant and non-malignant disease. Lancet 1995, 346:214-219.
8. Kurtzberg J, Laughlin M, Graham ML, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated donors. N Engl J Med 1996, 335:157-166.
9. Wagner JE, Rosenthal J, Sweetman R, et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood 1996, 88:795-802.
10. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord blood transplantation from related and unrelated donors: Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997, 337:373-381.
11. Rubinstein P, Carrier C, Scaradavou A, et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998, 339:1565-1577.
12. Wagner JE, Barker JN, DeFor TE, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and non-malignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 2002, 100:1611-1618.
13. Broxmeyer HE, Smith FO Cord blood hematopoietic cell transplantation. Thomas' Hema-topoietic Cell Transplantation 2004, 550-564. Blackwell Scientific Publications, Cambridge, Mass. 3rd ed. K.G. Blume, S.J. Forman, F.R. Appelbaum (Eds.).
14. Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001, 344:1815-1822.
15. Sanz GF, Saavedra S, Jimenez C, et al. Unrelated donor cord blood transplantation in adults with chronic myelogenous leukemia: results in nine patients from a single institution. Bone Marrow Transplant 2001, 27:693-701.
16. Ooi J, Iseki T, Takahashi S, et al. A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission. Br J Haematol 2002, 118:140-143.
17. Sanz GF, Saavedra S, Planelles D, et al. Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 2001, 98:2332-2338.
18. Long GD, Laughlin M, Madan B, et al. Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant 2003, 9:772-780.
19. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004, 351:2265-2275.
20. Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004, 351:2276-2285.
21. Takahashi S, Iseki T, Ooi J, et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 2004, 104:3813-3820.
22. Gluckman E, Rocha V, Arcese W, et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 2004, 32:397-407.
23. Cornetta K, Laughlin M, Carter S, et al. Umbilical cord blood transplantation in adults: results of the prospective cord blood transplantation (COBLT). Biol Blood Marrow Transplant 2005, 11:149-160.
24. Tse W, Laughlin MJ Cord blood transplantation in adult patients. Cytotherapy 2005, 7:228-242.
25. Sanz MA Cord blood transplantation in patients with leukemia: a real alternative for adults. N Engl J Med 2004, 351:2328-2330.
26. Chao NJ Stem cell transplantation (cord blood transplants): how close are we to using this in adults?. Hematology 2004, 355-359. American Society of Hematology, Washington, D.C. V.C. Broudy, N. Berliner, R.A. Larson (Eds.).
27. Chao NJ, Liu CX, Rooney B, et al. Non myeloablative regimen preserves "niches" allowing for peripheral expansion of donor T cells. Biol Blood Marrow Transplant 2002, 8:249-256.
28. Barker JN, Weisdorf DJ, DeFor TE, et al. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning. Blood 2003, 102:1915-1919.
29. Broxmeyer HE, Hangoc G, Cooper S, et al. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation of adults. Proc Natl Acad Sci USA 1992, 89:4109-4113.
30. +++ human umbilical cord blood hematopoietic progenitor cells with high proliferative and replating potential. Blood 1993, 81:41-48.
31. Lansdorp PM, Dragowska W, Mayani H Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 1993, 178:787-791.
32. +D38- human umbilical cord blood cells reveals their potentiality to engraft adults. Proc Natl Acad Sci USA 1993, 90:8707-8711.
33. Carow C, Hangoc G, Cooper S, et al. Mast cell growth factor (c-kit ligand) supports the growth of human multipotential (CFU-GEMM) progenitor cells with a high replating potential. Blood 1991, 78:2216-2221.
34. Carow CE, Hangoc G, Broxmeyer HE Human multipotential progenitor cells (CFU-GEMM) have extensive replating capacity for secondary CFU-GEMM: an effect enhanced by cord blood plasma. Blood 1993, 81:942-949.
35. Vormoor J, Lapidot T, Pflumio F, et al. Immature human cord blood progenitors engraft and proliferate to high levels in immune-deficient SCID mice. Blood 1994, 83:2489-2497.
36. Orazi A, Braun SE, Broxmeyer HE Immunohistochemistry represents a useful tool to study human cell engraftment in SCID mice transplantation models. Blood Cells 1994, 20:323-330.
37. Bock TA, Orlic D, Dunbar CE, et al. Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes. J Exp Med 1995, 182:2037-2043.
38. Broxmeyer HE Proliferation, self-renewal, and survival characteristics of cord blood hematopoietic stem and progenitor cells. Cord Blood: Biology, Immunology, Banking, and Clinical Transplantation 2004, 1-21. American Association of Blood Banking, Bethesda, Md. H.E. Broxmeyer (Ed.).
39. Shen BJ, Hou HS, Zhang HQ, et al. Unrelated, HLA-mismatched multiple human umbilical cord blood transfusion in four cases with advanced solid tumors: Initial studies. Blood Cells 1994, 2/3:285-292.
40. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005, 105:1343-1347.
41. Shpall EJ, Quinones R, Giller R, et al. Transplantation of ex vivo expanded cord blood. Biol Bone Marrow Transplant 2002, 8:368-376.
42. Jaroscak J, Goltry K, Smith A, et al. Augmentation of umbilical cord blood (UCB) transplantation with ex-vivo-expanded UCB cells: results of a phase I trial using the AstromReplicell system. Blood 2003, 101:5061-5067.
43. Shaheen M, Broxmeyer HE The humoral regulation of hematopoiesis. Hematology: Basic Principles and Practice 2005, 233-265. Elsevier/Churchill Livingstone, Philadelphia. 4th ed. R. Hoffman, E. Benz, S. Shattil (Eds.).
44. + hematopoietic precursors. Blood 1994, 83:2057-2062.
45. Varnum-Finney B, Purton LE, Yu M, et al. The notch ligand, jagged-1, influences the development of primitive hematopoietic precursor cells. Blood 1998, 91:4084-4091.
46. Varnum-Finney B, Brashem-Stein C, Bernstein ID Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 2003, 101:1784-1789.
47. Suzuki T, Chiba S Notch signaling in hematopoietic stem cells. Int J Hematol 2005, 82:285-294.
48. Austin TW, Solar GP, Ziegler FC, et al. A role for Wnt gene family in hematopoiesis: Expression of multilineage progenitor cells. Blood 1997, 89:3624-3635.
49. Van DerBerg DJ, Sharma AK, Bruno E, et al. Role of members of the Wnt gene family in human hematopoiesis. Blood 1998, 92:3189-3202.
50. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 2003, 423:409-414.
51. Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003, 423:448-452.
52. Antonchuk J, Sauvageau G, Humphries RK HOXB4 overexpression mediates very rapid stem cell regulation and competitive hematopoi-etic repopulation. Exp Hematol 2001, 29:1125-1134.
53. Buske C, Feuring-Buske M, Abramovich C, et al. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 2002, 100:862-868.
54. Antonchuk J, Sauvageau G, Humphries RK HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002, 109:39-45.
55. Kyba M, Perlingeiro RCR, Daley GQ HoxB4 confers definitive lym-phoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 2002, 109:29-37.
56. Krosi J, Beslu N, Mayotte N, et al. The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity 2003, 18:561-571.
57. Krosl J, Austin P, Beslu N, et al. In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 2003, 9:1428-1432.
58. Amsellem S, Pflumio F, Bardinet D, et al. Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeopro-tein. Nat Med 2003, 9:1423-1427.
59. Park I-K, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003, 423:302-305.
60. Lessard J, Sauvageau G Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003, 423:255-260.
61. Iwama A, Oguro H, Negishi M, et al. Enhanced self-renewal of hema-topoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004, 21:843-851.
62. Delaney C, Varnum-Finney B, Aoyama K, et al. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood 2005, 106:2693-2699.
63. Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 2005, 6:314-322.
64. Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoi-etic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα. Immunity 2004, 21:853-863.
65. Hock H, Hamblen MJ, Rooke HM, et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 2004, 431:1002-1007.
66. Zeng H, Yücel R, Kosan C, et al. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 2004, 23:4116-4125.
67. Schuringa JJ, Chung KY, Morrone G, et al. Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. J Exp Med 2004, 200:623-635.
68. Kato Y, Iwama A, Tadokoro Y, et al. Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hema-topoiesis. J Exp Med 2005, 202:169-179.
69. Oh IH, Eaves CJ Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene 2002, 21:4778-4787.
70. Niwa H, Burdon T, Chambers I, et al. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 1998, 12:2048-2060.
71. Guo Y, Hangoc G, Bian H, et al. SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells. Stem Cells 2005, 23:1324-1332.
72. Guo Y, Graham-Evans B, Broxmeyer HE Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells. Stem Cells 2005, (in press).
73. Christopherson KW, Broxmeyer HE Hematopoietic stem and progenitor cell homing, engraftment, and mobilization in the context of the CXCL12/SDF-1 - CXCR4 Axis. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 65-86. American Association of Blood Banks Press, Bethesda, Md. H.E. Broxmeyer (Ed.).
74. Lapidot T, Dar A, Kollet O How do stem cells find their way home?. Blood 2005, 106:1901-1910.
75. + progenitor cells. J Immunol 2002, 169:7000-7008.
76. Christopherson KW, Hangoc G, Mantel C, et al. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004, 305:1000-1003.
77. + cell engraftment of NOD/SCID mice. Blood 2005, 106(Pt 1):487a. (Abstract 1708).
78. Bodine DM Animal models for the engraftment and differentiation of human hematopoietic stem and progenitor cells. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 47-64. American Association of Blood Banks Press, Bethesda, Md. H.E. Broxmeyer (Ed.).
79. Broxmeyer HE, Cooper S High efficiency recovery of immature hematopoietic progenitor cells with extensive proliferative capacity from human cord blood cryopreserved for ten years. Clin Exp Immunol 1997, 107:45-53.
80. Broxmeyer HE, Srour EF, Hangoc G, et al. High efficiency recovery of hematopoietic progenitor cells with extensive proliferative and ex-vivo expansion activity and of hematopoietic stem cells with NOD/SCID mouse repopulation ability from human cord blood stored frozen for 15 years. Proc Natl Acad Sci USA 2002, 100:645-650.
81. Wood EJ, Liu J, Pollok K, et al. A theoretically optimized method for cord blood stem cell cryopreservation. J Hematother Stem Cell Res 2003, 12:341-350.
82. Ballen K, Broxmeyer HE, McCulloch J, et al. Current status of cord blood banking and transplantation in the United States and Europe. Biol Blood Marrow Transplant 2001, 7:635-645.
83. Ballen KK New trends in umbilical cord blood transplantation. Blood 2005, 105:3786-3792.
84. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program 2005, The National Academies Press, Washington, D.C. E.A. Meyer, K. Hanna, K. Gebbre (Eds.).
85. Smith FO Immune reconstitution following umbilical cord blood transplantation. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 151-162. AABB Press, Bethesda, Md. H.E. Broxmeyer (Ed.).
86. Gluckman JC, Canque B Dendritic cell and lymphoid progenitors in cord blood. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 163-185. AABB Press, Bethesda, Md. H.E. Broxmeyer (Ed.).
87. Navarrete CV, Gomez J, Borras FE Cord blood dendritic cells. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 187-198. AABB, Bethesda, Md. H.E. Broxmeyer (Ed.).
88. Kim Y-J, Broxmeyer HE Cytotoxic T lymphocytes in the context of cord blood transplantation. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 199-217. AABB, Bethesda, Md. H.E. Broxmeyer (Ed.).
89. Phillips RL, Ernst RE, Brunk B, et al. The genetic program of hematopoietic stem cells. Science 2000, 288:1635-1640.
90. Ramalho-Santos M, Yoon S, Matsuzaki Y, et al. "Stemness": Transcriptional profiling of embryonic and adult stem cells. Science 2002, 298:597-600.
91. Ivanova NB, Dimos JT, Schaniel C, et al. A stem cell molecular signature. Science 2002, 298:601-604.
92. + cells treated with VP-16 etoposide. Exp Hematol 2003, 31:251-260.
93. Tao W, Broxmeyer HE Toward a molecular understanding of hematopoietic stem and progenitor cells. Cord Blood: Biology, Immunology, and Clinical Transplantation 2004, 87-123. AABB Press, Bethesda, Md. H.E. Broxmeyer (Ed.).
94. + myeloid cells. Stem Cells 2004, 22:1003-1014.
95. Crisa L, Cirulli V, Smith K, et al. Human cord blood progenitors sustain thymic T-cell development and a novel form of angiogenesis. Blood 1999, 94:3928-3940.
96. Peichev M, Naiyer A, Pereira D, et al. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 2000, 95:952-958.
97. Kang HJ, Kim SC, Kim YJ, et al. Short-term phytohaemagglutinin-activated mononuclear cells induce endothelial progenitor cells from cord blood CD34+ cells. Br J Haematol 2001, 113:962-969.
98. Pesce M, Orlandi A, Iachininoto MG, et al. Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues. Circ Res 2003, 93:e51-e62.
99. Eggermann J, Kliche S, Jarmy G, et al. Endothelial progenitor cell culture and differentiation in vitro: a methodological comparison using human umbilical cord blood. Cardiovasc Res 2003, 58:478-486.
100. Fan C-L, Li Y, Gao P-J, et al. Differentiation of endothelial progenitor cells from human umbilical cord blood CD34+ cells in vitro. Acta Pharmacol Sin 2003, 24:212-218.
101. Murga M, Yao L, Tosato G Derivation of endothelial cells from CD34-umbilical cord blood. Stem Cells 2004, 22:385-395.
102. Hildbrand P, Cirulli V, Prinsen RC, et al. The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors. Blood 2004, 107:2010-2019.
103. Ingram D, Mead L, Tanaka H, et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004, 104:2752-2760.
104. Aoki M, Yasutake M, Murohara T Derivation of functional endothelial progenitor cells from human umbilical card blood mononuclear cells isolated by a novel cell filtration device. Stem Cells 2004, 22:994-1002.
105. Bompais H, Chagraoui J, Canron X, et al. Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells. Blood 2004, 107:25777-25784.
106. Parker GC, Anastassova-Kristeva M, Broxmeyer HE, et al. Stem cells: Shibboleths of development. Stem Cell Dev 2004, 13:579-584.
107. Parker GC, Anastassova-Kristeva M, Eisenberg LM, et al. Stem cells: Shibboleths of development. Part II: Toward a functional definition. Stem Cell Dev 2005, 14:463-469.
108. Javazon EH, Beggs KJ, Flake AW Mesenchymal stem cells: Paradoxes of passaging. Exp Hematol 2004, 32:414-425.
109. Erices A, Conget P, Minguell JJ Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000, 109:235-242.
110. Goodwin HS, Bicknese AR, Chien SN, et al. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat and neural markers. Biol Blood Marrow Transplant 2001, 7:581-588.
111. Bieback K, Kern S, Kluter H, et al. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cell 2004, 22:625-634.
112. Yang S-E, Ha C-W, Jung MH, et al. Mesenchymal stem/progenitor cells developed in cultures from UC blood. Cytotherapy 2004, 6:476-486.
113. Lee OK, Kuo TK, Chen W-M, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004, 103:1669-1675.
114. Rosada C, Justesen J, Melsvik D, et al. The human umbilical cord blood: A potential source for osteoblast progenitor cells. Calcif Tissue Int 2003, 72:135-142.
115. Bonanno G, Perillo A, Rutella S, et al. Clinical isolation and functional characterization of cord blood CD133+ hematopoietic progenitor cells. Transfusion 2004, 44:1087-1097.
116. Gutierrez-Rodriguez M, Reyes-Maldonado E, Mayani H Characterization of the adherent cells developed in Dextertype long-term cultures from human umbilical cord blood. Stem Cell 2000, 18:45-52.
117. Mareschi K, Biasin E, Piacibello W, et al. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haema-tologica 2001, 86:1099-1100.
118. Wexler S, Donaldson C, Denning-Kendall P, et al. Adult bone marrow is a rich source of human mesenchymal "stem" cells but umbilical cord and mobilized adult blood are not. Br J Haematol 2003, 121:368-374.
119. Lee MW, Choi J, Yang MS, et al. Mesenchymal stem cells from cryopreserved human umbilical cord blood. Biochem Biophys Res Commun 2004, 320:273-278.
120. Reyes M, Lund T, Lenvik T, et al. Purification and ex-vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001, 98:2615-2625.
121. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002, 418:41-49.
122. Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002, 109:1291-1302.
123. Jiang Y, Vaessen B, Lenvik T, et al. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 2002, 30:896-904.
124. Reyes M, Dudek A, Jahagirdar B, et al. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002, 109:337-346.
125. Adassi A, Verfaille CM Multipotent adult progenitor cells. Handbook of Stem Cells, Vol 2: Adult and Fetal Cells 2004, 293-297. Elsevier Academic Press, Amsterdam. R. Lanza, H. Blau, D. Melton (Eds.).
126. Kogler G, Sensken S, Airey J, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004, 200:123-135.
127. Wagers A, Weissman I Plasticity of adult stem cells. Cell 2004, 116:639-648.
128. Verfaillie C "Adult" stem cells: Tissue specific or not?. Handbook of Stem Cells, Vol 2: Adult and Fetal Cells 2004, 13-20. Elsevier Academic Press, Amsterdam. R. Lanza, H. Blau, D. Melton (Eds.).
129. Goodell MA Potential nonhematopoietic uses for stem cells in cord blood. Cord Blood, Establishing a National Hematopoietic Stem Cell Bank Program 2005, 208-220. Institute of Medicine of the National Academies, Washington, D.C. E.A. Meyer, K. Hanna, K. Gebbre (Eds.).