Genetic regulation of hypothalamic cocaine and amphetamine-regulated transcript (CART) in BxD inbred mice

Brain Research

Volumn 1194, Issue , 2008, Pages 1-7

  Boone, Ericka M ^a,c   Hawks, Brian W ^b,c   Li, Wei ^c   Garlow, Steven J ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Rehab Center ^*  (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BxD; Cocaine and amphetamine regulated transcript; Hypothalamus; Quantitative trait locus; Recombinant inbred mice; RT PCR

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; RNA; MESSENGER RNA; NERVE PROTEIN;

ANIMAL TISSUE; ARTICLE; CHROMOSOME 11; CHROMOSOME 4; CHROMOSOME NOR; GENETIC CORRELATION; GENETIC REGULATION; GENETIC VARIABILITY; HYPOTHALAMUS; INBREEDING; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; ANIMAL; C57BL MOUSE; CHROMOSOME MAP; CROSS BREEDING; DBA MOUSE; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GENETICS; METABOLISM; TRANSGENIC MOUSE;

MUS;

ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; GENE EXPRESSION REGULATION; HYPOTHALAMUS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; QUANTITATIVE TRAIT LOCI; RECOMBINATION, GENETIC; REGRESSION ANALYSIS; RNA, MESSENGER;

EID: 39149099438     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.11.074     Document Type: Article

References (57)

1. Allan M.F., Eisen E.J., and Pomp D. Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice. Genetics 170 (2005) 1863-1877
2. Balkan B., Gozen O., Yararbas G., Koylu E.O., Akinturk S., Kuhar M.J., and Pogun S. CART expression in limbic regions of rat brain following forced swim stress: sex differences. Neuropeptides 40 (2006) 185-193
3. Belknap J.K., Phillips T.J., and O'Toole L.A. Quantitative trait loci associated with brain weight in BxD/Ty recombinant inbred mouse strains. Brain Res Bulletin 29 (1992) 337-344
4. Bevova M.R., Aulchenko Y.S., Aksu S., Renne U., and Brockman G.A. Chromosome-wise dissection of the genome of the extremely big mouse line DU61. Genetics 172 (2006) 401-410
5. Blake J.A., Richardson J.E., Bult C.J., Kadin J.A., Eppig J.T., Group, and a.t.m.o.t.M.G.D. The Mouse Genome Database. Nuc. Acid Res. 31 (2003) 193-195
6. Buck K.J., and Hood H.M. Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mamm Genome 9 (1998) 975-978
7. Buck K.J., Metten P., Belknap J.K., and Crabbe J.C. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J. Neurosci 17 (1997) 3946-3955
8. Churchill G.A., and Doerge R.W. Empirical threshold values for quantitative trait mapping. Genetics 138 (1994) 963-971
9. Couceyro P.R., Evans C., McKinzie A., Mitchell D., Dube M., Hagshenas L., White F.J., Douglass J., Richards W.G., and Bannon A.W. Cocaine and amphetamine-regulated transcript (CART) peptides modulate the locomotor and motivational properties of psychostimulants. J. Pharmacol. Exp. Ther. 315 (2005) 1091-1000
10. Couceyro P.R., Koylu E.O., and Kuhar M.J. Further studies on the anatomical distribution of CART by in situ hybridization. J. Chem Neuroanat. 12 (1997) 229-241
11. Dallvechia-Adams S., Kuhar M.J., and Smith Y. Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: co-localization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons. J. Comp. Neurol. 448 (2002) 360-372
12. Darvasi A., and Soller M. A simple method to calculate resolving power and confidence interval of QTL map location. Behav Genetics 27 (1997) 125-132
13. Dominguez G., Vicentic A., Del Giudice E.M., Jaworski J., Hunter R.G., and Kuhar M.J. CART peptides: modulators of mesolimbic dopamine, feeding and stress. Ann. N..Y Acad. Sci. 1025 (2004) 363-369
14. Dominguez G., and Kuhar M.J. Transcriptional regulation of the CART promoter in CATH.a cells. Brain Res Mol Brain Res 126 (2004) 22-29
15. Dominguez G., Lakatos A., and Kuhar M.J. Characterization of the CART peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH2 cells. J. Neurochem 80 (2002) 885-893
16. Douglass J., McKinzie A.A., and Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 15 (1995) 2471-2481
17. Erwin, V.G., Markel P.D., Johnson T.E., Gehle V.M., and Jones B.C. Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects. J. Pharm. Exp. Therapeutics. 280 (1997) 911-918
18. Garlow S.J., Boone E., Kinkead B., and Nemeroff C.B. Genetic analysis of the hypothalamic neurotensin system. Neuropsychopharmacology 31 (2006) 535-543
19. Garlow S.J., Boone E., Li W., Owens M.J., and Nemeroff C.B. Genetic analysis of the hypothalamic corticotropin releasing factor (CRF) system. Endocrinology 146 (2005) 2362-2368
20. Gora-Masalak G., McClearn G.E., Crabbe J.C., Phillips T.J., Belknap J.K., and Plomin R. Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharm 104 (1991) 413-424
21. Haley C.S., and Knott S.A. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69 (1992) 315-324
22. Hubert G.W., and Kuhar M.J. Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens. Neuropeptides 40 (2006) 409-415
23. Hunter R.G., Vicentic A., Rogge G., and Kuhar M.J. The effects of cocaine on CART expression in the rat nucleus accumbens: a possible role for corticosterone. Eur. J. Pharmacol. 517 (2005) 45-50
24. Jaworski J.N., Kimmel H.L., Mitrano D.A., Tallarida R.J., and Kuhar M.J. Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis. Neuropeptides 41 (2007) 65-72
25. Jaworski J.N., Kozel M.A., Philpot K.B., and Kuhar M.J. Intra-accumbal injection of CART (cocaine and amphetamine-regulated transcript) peptide reduces cocaine-induced locomotor activity. J. Pharmacol. Exper. Ther. 307 (2003) 1038-1044
26. Jones B.C., Reed C.L., Hitzemann R., Wiesinger J.A., McCarthy K.A., Buwen J.P., and Beard J.L. Quantitative genetic analysis of ventral midbrain and liver iron in BxD recombinant inbred mice. Nutr. Neurosci 6 (2003) 369-377
27. Jones B.C., Tarantino L.M., Rodriguez L.A., Reed C.L., McClearn G.E., Plomin R., and Erwin V.G. Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry. Pharmacogenetics 9 (1999) 607-617
28. Kimmel H.L., Gong W., Vechia S.D., Hunter R.G., and Kuhar M.J. Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. J. Pharm. Exp Ther. 294 (2000) 784-792
29. Kirstein S.L., Davidson K.L., Ehringer M.A., Sikela J.M., Erwin V.G., and Tabakoff B. Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BxD recombinant inbred mice. J. Pharmacol Exp. Ther 302 (2002) 1238-1245
30. Koylu E.O., Couceyro P.R., Lambert P.D., and Kuhar M.J. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp. Neurol 391 (1998) 115-132
31. Koylu E.O., Couceyro P.R., Lambert P.D., Ling N.C., DeSouza E.B., and Kuhar M.J. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J. Neuroendocrinol. 9 (1997) 823-833
32. Kuhar M.J., Jaworski J.N., Hubert G.W., Philpot K.B., and Dominguez G. Cocaine and amphetamine regulated transcript peptides play a role in drug abuse and are potential therapeutic targets. AAPS J. 7 (2005) E259-E265
33. Lakatos A., Dominguez G., and Kuhar M.J. CART promoter CRE site binds phosphorylated CREB. Brain Res. Mol. Brain Res. 104 (2002) 81-85
34. Lander E.S., and Kruglyak L. Genetic dissection of complex traits - guidelines for interpreting and reporting linkage results. Nat. Genet 11 (1995) 241-247
35. Lander E.S., and Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121 (1989) 185-199
36. Larsen P.J., Seier V., Fink-Jensen A., Holst J., Warberg J., and Vrang N. Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit. J. Neuroendocrinol. 15 (2003) 219-226
37. Manly K., Cudmore J.R.H., and Meer J.M. Map Manager QTX, cross-platform software for genetic mapping. Mammal Gen. 12 (2001) 930-932
38. Mattson B.J., and Morrell J.I. Preference for cocaine versus pup-associated cues differentially activates neurons expressing either Fos or CART in lactating, maternal rodents. Neuroscience 135 (2005) 315-328
39. Moody D.E., Pomp D., Nielsen M.K., and Van Vleck L.D. Identification of quantitative trait loci influencing traits related to energy balance in selection and Inbred lines of mice. Genetics 152 (1999) 699-711
40. Neumann P.E. Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice. Behavior Genetics 22 (1992) 665-676
41. Plum L., Kluge R., Giesen K., Altmuller J., Ortlepp J.R., and Joost H.G. Type-2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of susceptibility locus on chromosome 4 and its relationship with obesity. Diabetes 49 (2000) 1590-1596
42. Rocha J.L., Eisen E.J., Van Vleck L.D., and Pomp D. A large-sample QTL study in mice: II Body composition. Mamm Genome 15 (2004) 100-113
43. Sanzchèz E., Fekete C., Lechan R.M., and Joseph-Bravo P. Cocaine- and amphetamine-regulated transcript (CART) expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulation. Brain Res. 9 (2007) 120-128
44. SAS Institute Inc., 2002. JMP Statistics and Graphics Guide, Version 5.
45. Shieh K.R. Effects of cocaine and amphetamine-regulated transcript peptide on turnover of central dopaminergic neurons. Neuropharmacology 44 (2003) 940-948
46. Stanley S.A., Small C.J., Murphy K.G., Rayes E., Abbott C.R., and Seal L.J. Actions of cocaine and amphetamine-regulated transcript peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain Res. 893 (2001) 186-194
47. TheComplexTraitConsortium. The nature and identification of quantitative trait loci: a community's view. Nat Reviews Genetics 4 (2003) 911-916
48. Ueda H., Ikegami H., Kawaguchi Y., Fulisawa T., Yamato E., Shibata M., and Ogihara T. Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes 48 (1999) 1168-1174
49. Van Vugt D.A., Lujan M.E., Froats M., Krzemien A., Couceyro P.R., and Reid R.L. Effect of fasting on cocaine-amphetamine-regulated transcript, neuropeptide Y, and leptin receptor expression in the non-human primate hypothalamus. Neuroendocrinology 84 (2006) 83-93
50. Vicentic A., Hunter R.G., and Kuhar M.J. Effect of corticosterone on CART peptide levels in rat blood. Peptides 26 (2005) 531-535
51. Vrang N., Tang-Christiansen M., Larsen L.K., and Kristensen P. Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour. Brain Res. 818 (1999) 499-509
52. Williams R.W., Gu J., and Lu L. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol. 2 (2001) 1-18.
53. Yang S.C., Pan J.T., and Li H.Y. CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study. Eur. J. Pharmacol. 494 (2004) 179-182
54. Yoshikawa T., Watanabe A., Ishitsuka Y., Nakaya A., and Nakatani N. Identification of multiple genetic loci linked to the propensity for 'behavioral despair' in mice. Genome Res. 12 (2002) 357-366
55. Zeng Z.B. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci. PNAS 90 (1993) 10972-10976
56. Zeng Z.B. Precision mapping of quantitative trait loci. Genetics 136 (1994) 1457-1468
57. Zhang S., and Gershenfeld H.K. Genetic contributions to body weight in mice: relationship of exploratory behavior to weight. Obes Res. 11 (2003) 828-838