Transcriptional regulation of the CART promoter in CATH.a cells

Molecular Brain Research

Volumn 126, Issue 1, 2004, Pages 22-29

  Dominguez, Geraldina ^a   Kuhar, Michael J ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

cAMP; Cart promoter regulation; CATH.a; Cellular and molecular biology; CRE; CREB; CRF; Promoter

Indexed keywords

BIOLOGICAL FACTOR; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; MESSENGER RNA; MUTANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; GENE CONSTRUCT; GENE CONTROL; GENE MUTATION; GENE SEQUENCE; LOCUS CERULEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA TRANSLATION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CELL LINE; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FORSKOLIN; GENE EXPRESSION REGULATION; LOCUS COERULEUS; MICE; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; NEUROTRANSMITTER AGENTS; PROMOTER REGIONS (GENETICS); PYRIMIDINES; PYRROLES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 2942659307     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.02.027     Document Type: Article

References (42)

1. Ahn S., Olive M., Aggarwal S., Krylov D., Ginty D.D., Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell. Biol. 18:1998;967-977
2. Balkan B., Koylu E.O., Kuhar M.J., Pogun S. The effect of adrenalectomy on cocaine and amphetamine-regulated transcript (CART) expression in the hypothalamic nuclei of the rat. Brain Res. 917:2001;15-20
3. Balkan B., Koylu E., Pogun S., Kuhar M.J. Effects of adrenalectomy on CART expression in the rat arcuate nucleus. Synapse. 50:2003;14-19
4. Barrett P., Morris M.A., Moar K.M., Mercer J.G., Davidson J.A., Findlay P.A., Adam C.L., Morgan P.J. The differential regulation of CART gene expression in a pituitary cell line and primary cell cultures of ovine pars tuberalis cells. J. Neuroendocrinol. 13:2001;347-352
5. Barrett P., Davidson J., Morgan P. CART gene promoter transcription is regulated by a cyclic adenosine monophosphate response element. Obes. Res. 10:2002;1291-1298
6. Berke J.D., Hyman S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron. 25:2000;515-532
7. Blendy J.A., Maldonado R. Genetic analysis of drug addiction: the role of cAMP response element binding protein. J. Mol. Med. 76:1998;104-110
8. Boundy V.A., Chen J., Nestler E.J. Regulation of cAMP-dependent protein kinase subunit expression in CATH.a and SH-SY5Y cells. J. Pharmacol. Exp. Ther. 286:1998;1058-1065
9. Cibelli G., Corsi P., Diana G., Vitiello F., Thiel G. Corticotropin-releasing factor triggers neurite outgrowth of a catecholaminergic immortalized neuron via cAMP and MAP kinase signalling pathways. Eur. J. Neurosci. 13:2001;1339-1348
10. Coven E., Ni Y., Widnell K.L., Chen J., Walker W.H., Habener J.F., Nestler E.J. Cell type-specific regulation of CREB gene expression: mutational analysis of CREB promoter activity. J. Neurochem. 71:1998;1865-1874
11. del Giudice E.M., Santoro N., Cirillo G., D'Urso L., Di Toro R., Perrone L. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes. 50:2001;2157-2160
12. Dey A., Xhu X., Carroll R., Turck C.W., Stein J., Steiner D.F. Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertasesm, PC2 and PC1/3. J. Biol. Chem. 278:2003;15007-15014
13. Dominguez G., Lakatos A., Kuhar M.J. Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells. J. Neurochem. 80:2002;885-893
14. Douglass J., McKinzie A.A., Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci. 15:1995;2471-2481
15. Fagergren P., Hurd Y.L. Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine. NeuroReport. 10:1999;3449-3452
16. Good D.J. How tight are your genes? Transcriptional and posttranscriptional regulation of the leptin receptor, NPY, and POMC genes. Horm. Behav. 37:2000;284-298
17. Jaworski J.N., Kozel M.A., Philpot K.B., Kuhar M.J. Intra-accumbal injection of CART peptide reduces cocaine-induced locomotor activity. J. Pharmacol. Exp. Ther. 2003;1038-1044
18. Jaworski J.N., Vicentic A., Hunter R.G., Kimmel H.L., Kuhar M.J. CART peptides are modulators of mesolimbic dopamine and psychostimulants. Life Sci. 73:2003;741-747
19. Kimmel H.L., Gong W., Vechia S.D., Hunter R.G., Kuhar M.J. Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. J. Pharmacol. Exp. Ther. 294:2000;784-792
20. Kimmel H.L., Thim L., Kuhar M.J. Activity of various CART peptides in changing locomotor activity in the rat. Neuropeptides. 36:2002;9-12
21. Koylu E.O., Couceyro P.R., Lambert P.D., Kuhar M.J. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp. Neurol. 391:1998;115-132
22. Koylu E.O., Smith Y., Couceyro P.R., Kuhar M.J. CART peptides colocalize with tyrosine hydroxylase neurons in rat locus coeruleus. Synapse. 31:1999;309-311
23. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., Clausen J.T., Jensen P.B., Madsen O.D., Vrang N., Larsen P.J., Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 393:1998;72-76
24. Kuhar M.J., Yoho L.L. CART peptide analysis by Western blotting. Synapse. 33:1999;163-171
25. Kuhar M.J., Adams L.D., Hunter R.G., Vechia S.D., Smith Y. CART peptides. Regul. Pept. 89:2000;1-6
26. Kuhar M.J., Adams S., Dominguez G., Jaworski J., Balkan B. CART peptides. Neuropeptides. 36:2002;1-8
27. Lakatos A., Dominguez G., Kuhar M.J. CART promoter CRE site binds phosphorylated CREB. Mol. Brain Res. 104:2002;81-85
28. Lambert P.D., Couceyro P.R., McGirr K.M., Dall Vechia S.E., Smith Y., Kuhar M.J. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse. 29:1998;293-298
29. Nestler E.J. Molecular basis of long-term plasticity underlying addiction. Nat. Rev., Neurosci. 2:2001;119-128
30. Page M.E., Abercrombie E.D. Discrete local application of corticotropin-releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus. Synapse. 33:1999;304-313
31. Savontaus E., Conwell I.M., Wardlaw S.L. Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Res. 958:2002;130-138
32. Smith Y., Kieval J., Couceyro P.R., Kuhar M.J. CART peptide- immunoreactive neurones in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents. J. Comp. Neurol. 407:1999;491-511
33. Suri C., Fung B.P., Tischler A.S., Chikaraishi D.M. Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. J. Neurosci. 13:1993;1280-1291
34. Tashjian A.H. Jr., Yasumura Y., Levine L., Sato G.H., Parker M.L. Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology. 82:1968;342-352
35. Thiel G., Cibelli G. Corticotropin-releasing factor and vasoactive intestinal polypeptide activate gene transcription through the cAMP signaling pathway in a catecholaminergic immortalized neuron. Neurochem. Int. 34:1999;183-191
36. Vrang N., Kristensen P., Tang-Christensen M., Larsen P.J. Effects of leptin on arcuate pro-opiomelanocortin and cocaine-amphetamine-regulated transcript expression are independent of circulating levels of corticosterone. J. Neuroendocrinol. 14:2002;880-886
37. Vrang N., Larsen P.J., Kristensen P. Cocaine-amphetamine regulated transcript (CART) expression is not regulated by amphetamine. NeuroReport. 13:2002;1215-1218
38. Vrang N., Larsen P.J., Tang-Christensen M., Larsen L.K., Kristensen P. Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids. Brain Res. 965:2003;45-50
39. Widnell K.L., Russell D.S., Nestler E.J. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proc. Natl. Acad. Sci. U. S. A. 91:1994;10947-10951
40. Widnell K.L., Chen J.S., Iredale P.A., Walker W.H., Duman R.S., Habener J.F., Nestler E.J. Transcriptional regulation of CREB (cyclic AMP response element-binding protein) expression in CATH.a cells. J. Neurochem. 66:1996;1770-1773
41. Xu W., Cooper G.M. Identification of a candidate c-mos repressor that restricts transcription of germ cell-specific genes. Mol. Cell. Biol. 15:1995;5369-5375
42. Yamada K., Yuan X., Otabe S., Koyanagi A., Koyama W., Makita Z. Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity. Int. J. Obes. Relat. Metab. Disord. 26:2002;132-136