Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit

Journal of Neuroendocrinology

Volumn 15, Issue 3, 2003, Pages 219-226

  Larsen, Philip Just ^a   Seier, V ^b   Fink Jensen, A ^b   Holst, J J ^b   Warberg, J ^b   Vrang, N ^a  

^a Rheoscience ^*  (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Fluorogold; Food intake; Hypothalamic releasing factor; Retrograde tracing

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CORTICOTROPIN RELEASING FACTOR; FLUOROGOLD; HYPOTHALAMUS RELEASING FACTOR; NITROPRUSSIDE SODIUM; PROOPIOMELANOCORTIN; PROTIRELIN; SOMATOSTATIN; TRACER;

ADENOHYPOPHYSIS; ANESTHESIA INDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; BLOOD SAMPLING; CELL COMPOSITION; CELL LABELING; COCHLEAR NUCLEUS; CONTROLLED STUDY; CYTOARCHITECTURE; EXPOSURE; FEEDING BEHAVIOR; HEMODYNAMIC PARAMETERS; HYPOTENSION; HYPOTHALAMUS FUNCTION; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOTHALAMUS NUCLEUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; INFUNDIBULUM; MEDIAN EMINENCE; NEUROSECRETORY CELL; NONHUMAN; PEPTIDE ANALYSIS; PORTAL VEIN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; REVIEW; STRESS; SUPRAOPTIC NUCLEUS; THALAMUS DORSOMEDIAL NUCLEUS; THALAMUS MIDLINE NUCLEUS; THALAMUS VENTRAL NUCLEUS; TISSUE FIXATION;

ANIMALS; COMMON VARIABLE IMMUNODEFICIENCY; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEURONS; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR; STRESS;

EID: 0037373452     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2003.00960.x     Document Type: Review

References (31)

1. Thim L, Kristensen P, Nielsen PF, Wulff BS, Clausen JT. Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat. Proc Natl Acad Sci USA 1999; 96: 2722-2727.
2. Koylu EO, Couceyro PR, Lambert PD, Ling NC, DeSouza EB, Kuhar MJ. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 1997; 9: 823-833.
3. Koylu EO, Couceyro PR, Lambert PD, Kuhar MJ. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J Comp Neurol 1998; 391: 115-132.
4. Vrang N, Larsen PJ, Clausen JT, Kristensen P. Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons. J Neurosci 1999; 19: 1-18.
5. Kristensen P, Judge M, Thim L, Ribel U, Christjansen K, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S. The hypothalamic peptide CART is regulated by leptin and counteracts NPY induced feeding. Nature (London) 1998; 393: 72-76.
6. Aja S, Schwartz GJ, Kuhar MJ, Moran TH. Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure. Am J Physiol 2001; 280: R1613-R1619.
7. Lambert PD, Couceyro PR, McGirr KM, Dall SE, Yoland V, Kuhar MJ. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 1998; 29: 293-298.
8. Vrang N, Tang-Christensen M, Larsen PJ, Kristensen P. Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour. Brain Res 1999; 818: 499-509.
9. Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, Zollner AN, Morgan DG, Morgan I, Ghatei MA, Small CJ, Bloom SR. Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology 2001; 142: 3457-3463.
10. Vrang N, Larsen PJ, Kristensen P, Tang-Christensen M. Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 2000; 141: 794-801.
11. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-252.
12. Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Bourguignon JP. Cocaine and amphetamine-regulated-transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro. J Neuroendocrinol 2000; 12: 383-385.
13. Shindler KS, Roth KA. Double immunofluorescent staining using two unconjugated primary antisera raised in the same species. J Histochem Cytochem 1996; 44: 1331-1335.
14. Munch IC, Moller M, Larsen PJ, Vrang N. Light-induced c-Fos expression in suprachiasmatic nuclei neurons targeting the paraventricular nucleus of the hamster hypothalamus: phase dependence and immunochemical identification. J Comp Neurol 2002; 442: 48-62.
15. Larsen PJ, Bersani M, Holst JJ, Moller M, Mikkelsen JD. Distribution and characterization of different molecular products of pro-somatostatin in the hypothalamus and posterior pituitary lobe of the Mongolian gerbil (Meriones unguiculatus). J Neurosci 1992; 12: 946-961.
16. Porter JC, Smith KR. Collection of hypophysial stalk blood in rats. Endocrinology 1967; 81: 1182-1185.
17. Merchenthaler I. Enkephalin-immunoreactive neurons in the parvicellular subdivisions of the paraventricular nucleus project to the external zone of the median eminence. J Comp Neurol 1992; 326: 112-120.
18. Larsen PJ, Moller M, Mikkelsen JD. Efferent projections from the periventricular and medial parvicellular subnuclei of the hypothalamic paraventricular nucleus to circumventricular organs of the rat: a Phaseolus vulgaris-leucoagglutinin (PHA-L) tracing study. J Comp Neurol 1991; 306: 462-479.
19. Plotsky PM. Opioid inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation of rats. Regul Pept 1986; 16: 235-242.
20. Broberger C. Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y. Brain Res 1999; 848: 101-113.
21. Plotsky PM, Bruhn TO, Vale W. Hypophysiotropic regulation of adrenocorticotropin secretion in response to insulin-induced hypoglycemia. Endocrinology 1985; 117: 323-329.
22. Tannahill LA, Sheward WJ, Robinson ICA, Fink G. Corticotrophin-releasing factor, vasopressin and oxytocin release into hypophysial portal in the rat: effects of electrical stimulation of the hypothalamus, amygdala and hippocampus. J Endocrinol 1990; 129: 99-107.
23. Engler D, Pham T, Fullerton MJ, Ooi G, Funder JW, Clarke IJ. Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia. Neuroendocrinology 1989; 49: 367-381.
24. Page RB. The pituitary portal system. In: Ganten D, Pfaff D, eds. Morphology of the Hypothalamus and Its Connections. Berlin: Springer-Verlag, 1981: 1-48.
25. Barrett P, Morris MA, Moar KM, Mercer JG, Davidson JA, Findlay PA, Adam CL, Morgan PJ. The differential regulation of cart gene expression in a pituitary cell line and primary cell cultures of ovine pars tuberalis cells. J Neuroendocrinol 2001; 13: 347-352.
26. Stanley SA, Small CJ, Murphy KG, Rayes E, Abbott CR, Seal LJ, Morgan DG, Sunter D, Dakin CL, Kim MS, Hunter R, Kuhar M, Ghatei MA, Bloom SR. Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain Res 2001; 893: 186-194.
27. Verbalis JG, McCann MJ, McHale MC, Stricker EM. Oxytocin secretion in response to cholecystokinin and food: Differentiation of nausea from satiety. Science 1986; 232: 1417-1419.
28. Fekete C, Mihaly E, Luo LG, Kelly J, Clausen JT, Mao Q, Rand WM, Moss LG, Kuhar M, Emerson CH, Jackson IM, Lechan RM. Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting. J Neurosci 2000; 20: 9224-9234.
29. Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 1998; 402: 442-459.
30. Simerly RB. Anatomical subtrates of hypothalamic intergration. In: Paxinos G, eds. The Rat Nervous System. San Diego: Academic Press, 1995: 353-376.
31. Swanson LW. The hypothalamus. In: Björklund A, Hökfelt T, Swanson LW, eds. Handbook of Chemical Neuroanatomy. Amsterdam: Elsevier, 1987: 1-124.