Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: An isobolographic analysis

Neuropeptides

Volumn 41, Issue 2, 2007, Pages 65-72

  Jaworski, Jason N ^a   Kimmel, Heather L ^a   Mitrano, Darlene A ^a   Tallarida, Ronald J ^b   Kuhar, Michael J ^a  

^a EMORY UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CART; Cocaine; Cocaine CART interaction; Dopamine; Medications development; Peptides; Psychostimulant; Ventral tegmental area

Indexed keywords

AMPHETAMINE; COCAINE; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; DOPAMINE; PSYCHOSTIMULANT AGENT;

ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ANIMALS; COCAINE; DOPAMINE UPTAKE INHIBITORS; DRUG INTERACTIONS; MALE; MICROINJECTIONS; MODELS, BIOLOGICAL; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; VENTRAL TEGMENTAL AREA;

RATTUS;

EID: 33847272036     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2006.12.003     Document Type: Article

References (29)

1. Albertson D.N., Pruetz B., Schmidt C.J., Kuhn D.M., Kapatos G., and Bannon M.J. Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J. Neurochem. 88 (2004) 1211-1219
2. Barrett P., Davidson J., and Morgan P. CART gene promoter transcription is regulated by a cyclic adenosine monophosphate response element. Obes. Res. 10 (2002) 1291-1298
3. Binder E., Kinkead B., and Nemeroff C. Neuropeptides. In: Breier A., Tran P., Herrea J., Tollefson G., and Bymaster F. (Eds). Current Issues in the Psychopharmacology of Schizophrenia (2001), Lippincott Williams & Wilkins, Philadelphia, PA 349-371
4. Brenz Verca M.S., Widmer D.A., Wagner G.C., and Dreyer J. Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function. Mol. Cell Neurosci. 17 (2001) 303-316
5. Carlezon Jr. W.A., Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., and Nestler E.J. Regulation of cocaine reward by CREB. Science 282 (1998) 2272-2275
6. Dallvechia-Adams S., Kuhar M.J., and Smith Y. Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons. J. Comp. Neurol. 448 (2002) 360-372
7. Dominguez G., Lakatos A., and Kuhar M.J. Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells. J. Neurochem. 80 (2002) 885-893
8. Douglass J., McKinzie A.A., and Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci. 15 (1995) 2471-2481
9. Fagergren P., and Hurd Y.L. Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine. Neuroreport 10 (1999) 3449-3452
10. Grabovsky Y., and Tallarida R.J. Isobolographic analysis for combinations of a full and partial agonist: curved isoboles. J. Pharmacol. Exp. Ther. 310 (2004) 981-986
11. Holtzman S.G. Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. Psychopharmacology (Berlin) 155 (2001) 180-186
12. Hunter, R., Kuhar, M., 2003. Dopaminergic regulation of CART mRNA in the nucleus accumbens. Society for Neuroscience Abstracts, 889, 21.
13. Jaworski J.N., Kozel M.A., Philpot K.B., and Kuhar M.J. Intra-accumbal injection of CART (cocaine-amphetamine regulated transcript) peptide reduces cocaine-induced locomotor activity. J Pharmacol Exp Ther 307 (2003) 1038-1044
14. Jaworski J.N., Vicentic A., Hunter R.G., Kimmel H.L., and Kuhar M.J. CART peptides are modulators of mesolimbic dopamine and psychostimulants. Life Sci 27 (2003) 741-747
15. June H.L., and Lewis M.J. Interactions of Ro15-4513, Ro15-1788 (flumazenil) and ethanol on measures of exploration and locomotion in rats. Psychopharmacology (Berlin) 116 (1994) 309-316
16. Kim J.H., Creekmore E., and Vezina P. Microinjection of CART peptide 55-102 into the nucleus accumbens blocks amphetamine-induced locomotion. Neuropeptides 37 (2003) 369-373
17. Kimmel H.L., Gong W., Vechia S.D., Hunter R.G., and Kuhar M.J. Intra-ventral tegmental area injection of rat cocaine and amphetamine- regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. J. Pharmacol. Exp. Ther. 294 (2000) 784-792
18. Koylu E.O., Couceyro P.R., Lambert P.D., and Kuhar M.J. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp. Neurol. 391 (1998) 115-132
19. Kuhar M.J., Adams S., Dominguez G., Jaworski J., and Balkan B. CART peptides. Neuropeptides 36 (2002) 1-8
20. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. fourth ed. (1986), Academic Press, New York
21. Pliakas A.M., Carlson R.R., Neve R.L., Konradi C., Nestler E.J., and Carlezon Jr. W.A. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J. Neurosci. 21 (2001) 7397-7403
22. Shieh K. Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of central dopaminergic neurons. Neuropharmacology 44 (2003) 940-948
23. Smith Y., Koylu E.O., Couceyro P., and Kuhar M.J. Ultrastructural localization of CART (cocaine- and amphetamine- regulated transcript) peptides in the nucleus accumbens of monkeys. Synapse 27 (1997) 90-94
24. Tallarida R.J. Drug Synergism and Dose-Effect Data Analysis (2000), Chapman-Hall/CRC, Boca Raton
25. Tallarida R.J. Drug synergism: its detection and applications. J. Pharmacol. Exp. Ther. 298 (2001) 865-872
26. Tallarida R.J., Kimmel H.L., and Holtzman S.G. Theory and statistics of detecting synergism between two active drugs: cocaine and buprenorphine. Psychopharmacology (Berlin) 133 (1997) 378-382
27. Tang W.X., Fasulo W.H., Mash D.C., and Hemby S.E. Molecular profiling of midbrain dopamine regions in cocaine overdose victims. J. Neurochem. 85 (2003) 911-924
28. Wang P.J., Stromberg M., Replenski S., Snyder-Mackler A., and Mackler S.A. The relationship between cocaine-induced increases in NAC1 and behavioral sensitization. Pharmacol. Biochem. Behav. 75 (2003) 49-54
29. Yang S.-C., Pan J.-T., and Li H.-Y. CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study. Eur. J. Pharmacol. 494 (2004) 179-182