Differential utilization of nuclear factor-κB signaling pathways for gingival epithelial cell responses to oral commensal and pathogenic bacteria

Oral Microbiology and Immunology

Volumn 23, Issue 2, 2008, Pages 119-126

  Chung, W O ^a   Dale, B A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Commensals; Gingival epithelium; Innate immunity; Nuclear factor B; Pathogens

Indexed keywords

CXCL14 CHEMOKINE; CYTOKINE; DEFENSIN 2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDE DERIVATIVE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EPITHELIUM CELL; FUSOBACTERIUM NUCLEATUM; GENETIC TRANSFECTION; GINGIVA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; INNATE IMMUNITY; KERATINOCYTE; MICROARRAY ANALYSIS; MOUTH FLORA; MOUTH MUCOSA; NEWBORN; NONHUMAN; PORPHYROMONAS GINGIVALIS; PROTEIN FAMILY; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

BETA-DEFENSINS; CELLS, CULTURED; GINGIVA; HUMANS; I-KAPPA B KINASE; IMMUNITY, MUCOSAL; INFLAMMATION; KERATINOCYTES; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 3;

EID: 39049103391     PISSN: 09020055     EISSN: 1399302X     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2007.00398.x     Document Type: Article

References (42)

1. Chung WO, Dale BA. Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species. Infect Immun 2004 : 72 : 352 358.
2. Chung WO, Hansen SR, Rao D, Dale BA. Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J Immunol 2004 : 173 : 5165 5170.
3. Clifton DR, Rydkina E, Freeman RS, Sahni SK. NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha. Infect Immun 2005 : 73 : 155 165.
4. Dale BA. Periodontal epithelium: a newly recognized role in health and disease. Periodontol 2000 2002 : 30 : 70 78.
5. Dale BA, Fredericks LP. Antimicrobial peptides in the oral environment: expression and function in health and disease. Curr Issues Mol Biol 2005 : 7 : 119 133.
6. Dale BA, Kimball JR, Krisanaprakornkit S et al. Localized antimicrobial peptide expression in human gingiva. J Periodontal Res 2001 : 36 : 285 294.
7. Diamond G, Kaiser V, Rhodes J, Russell JP, Bevins CL. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect Immun 2000 : 68 : 113 119.
8. Diamond G, Russell JP, Bevins CL. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci USA 1996 : 93 : 5156 5160.
9. Dinulos JG, Mentele L, Fredericks LP, Dale BA, Darmstadt GL. Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diagn Lab Immunol 2003 : 10 : 161 166.
10. Eaves-Pyles T, Murthy K, Liaudet L et al. Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol 2001 : 166 : 1248 1260.
11. Feucht EC, DeSanti CL, Weinberg A. Selective induction of human beta-defensin mRNAs by Actinobacillus actinomycetemcomitans in primary and immortalized oral epithelial cells. Oral Microbiol Immunol 2003 : 18 : 359 363.
12. Fischer H, Yamamoto M, Akira S, Beutler B, Svanborg C. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur J Immunol 2006 : 36 : 267 277.
13. Ganz T. Defensins: antimicrobial peptides of vertebrates. C R Biol 2004 : 327 : 539 549.
14. Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 2001 : 167 : 1882 1885.
15. Hancock RE, Scott MG. The role of antimicrobial peptides in animal defenses. Proc Natl Acad Sci USA 2000 : 97 : 8856 8861.
16. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001 : 276 : 5707 5713.
17. Harder J, Meyer-Hoffert U, Teran LM et al. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000 : 22 : 714 721.
18. Hayashi F, Smith KD, Ozinsky A et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001 : 410 : 1099 1103.
19. Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 2001 : 410 : 710 714.
20. Krisanaprakornkit S, Jotikasthira D, Dale BA. Intracellular calcium in signaling human beta-defensin-2 expression in oral epithelial cells. J Dent Res 2003 : 82 : 877 882.
21. Krisanaprakornkit S, Kimball JR, Dale BA. Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family. J Immunol 2002 : 168 : 316 324.
22. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000 : 68 : 2907 2915.
23. Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA. Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 1998 : 66 : 4222 4228.
24. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 2005 : 434 : 1138 1143.
25. Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr Opin Immunol 2002 : 14 : 96 102.
26. Li ZW, Chu W, Hu Y et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999 : 189 : 1839 1845.
27. Luftig M, Yasui T, Soni V et al. Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci USA 2004 : 101 : 141 146.
28. Macpherson AJ, Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 2004 : 303 : 1662 1665.
29. Massa PE, Li X, Hanidu A et al. Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes. J Biol Chem 2005 : 280 : 14057 14069.
30. Mathews M, Jia HP, Guthmiller JM et al. Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999 : 67 : 2740 2745.
31. Mynott TL, Crossett B, Prathalingam SR. Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells. Infect Immun 2002 : 70 : 86 95.
32. O'Neil DA, Porter EM, Elewaut D et al. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999 : 163 : 6718 6724.
33. Pomerantz JL, Baltimore D. Two pathways for NFkB. Mol Cell 2002 : 10 : 693 701.
34. Premratanachai P, Joly S, Johnson GK, McCray PB Jr., Jia HP, Guthmiller JM. Expression and regulation of novel human beta-defensins in gingival keratinocytes. Oral Microbiol Immunol 2004 : 19 : 111 117.
35. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004 : 118 : 229 241.
36. Roberts FA, Darveau RP. Beneficial bacteria of the periodontium. Periodontol 2000 2002 : 30 : 40 50.
37. Sansonetti P. Host-pathogen interactions: the seduction of molecular cross talk. Gut 2002 : 50 (Suppl. 3 III2 III8.
38. Schroder NW, Opitz B, Lamping N et al. Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids. J Immunol 2000 : 165 : 2683 2693.
39. Schutte BC, Mitros JP, Bartlett JA et al. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 2002 : 99 : 2129 2133.
40. Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol 2005 : 6 : 551 557.
41. Sizemore N, Lerner N, Dombrowski N, Sakurai H, Stark GR. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem 2002 : 277 : 3863 3869.
42. Wehkamp J, Harder J, Wehkamp K et al. NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun 2004 : 72 : 5750 5758.