Expression and regulation of novel human β-defensins in gingival keratinocytes

Oral Microbiology and Immunology

Volumn 19, Issue 2, 2004, Pages 111-117

  Premratanachai, P ^a,b   Joly, S ^a   Johnson, G K ^a,b   McCray Jr , P B ^a   Jia, H P ^a   Guthmiller, Janet M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

defensins; Antimicrobial peptides; Gene expression; Gingival keratinocytes; Innate immunity

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA DEFENSIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN DEFB 104; PROTEIN DEFB 107; PROTEIN DEFB 108; PROTEIN DEFB 109; PROTEIN DEFB 111; PROTEIN DEFB 112; PROTEIN DEFB 114; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA; CANDIDA ALBICANS; CONTROLLED STUDY; DOWN REGULATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE INDUCTION; GINGIVA; HUMAN; HUMAN TISSUE; KERATINOCYTE; MOUTH INFECTION; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CANDIDA; CANDIDA ALBICANS; CYTOKINES; DOWN-REGULATION; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GINGIVA; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; KERATINOCYTES; LIPOPOLYSACCHARIDES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1442338497     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0902-0055.2002.00127.x     Document Type: Article

References (55)

1. Bals R, Wang X, Wu Z, et al. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998: 102: 874-880.
2. Bensch KW, Raida M, Magert HJ, Schulz-Knappe P, Forssmann WG. hBD-1: a novel β-defensin from human plasma. FEBS Lett 1995: 368: 331-335.
3. Bissell J, Joly S, Johnson GK, et al. Expression of β-defensins in gingival health and in periodontal disease. J Oral Pathol Med. In press.
4. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987: 162: 156-159.
5. Cruz MT, Duarte CB, Goncalo M, Carvalho AP, Lopes MC. Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells. Am J Physiol 1999: 277: C1050-C1057.
6. Dale BA, Krisanaprakornkit S. Defensin antimicrobial peptides in the oral cavity. J Oral Pathol Med 2001: 30: 321-327.
7. Dale BA, Kimball JR, Krisanaprakornkit S, et al. Localized antimicrobial peptide expression in human gingiva. J Periodontal Res 2001: 36: 285-294.
8. Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 1991: 88: 3952-3956.
9. Dunsche A, Acil Y, Siebert R, Harder J, Schroder JM, Jepsen S. Expression profile of human defensins and antimicrobial proteins in oral tissues. J Oral Pathol Med 2001: 30: 154-158.
10. Dunsche A, Acil Y, Dommisch H, Siebert R, Schroder JM, Jepsen S. The novel human β-defensin-3 is widely expressed in oral tissues. Eur J Oral Sci 2002: 110: 121-124.
11. Ganster RW, Taylor BS, Shao L, Geller DA. Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-κB. Proc Natl Acad Sci USA 2001: 98: 8638-8643.
12. Ganz T, Lehrer RI. Defensins. Pharmacol Ther 1995: 66: 191-205.
13. Ganz T, Weiss J. Antimicrobial peptides of phagocytes and epithelia. Semin Hematol 1997: 34: 343-354.
14. Garcia JR, Jaumann F, Schulz S, et al. Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res 2001: 306: 257-264.
15. Garcia JR, Krause A, Schulz S, et al. Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 2001: 15: 1819-1821.
16. Germann T, Rude E, Schmitt E. The influence of IL 12 on the development of Th1 and Th2 cells and its adjuvant effect for humoral immune responses. Res Immunol 1995: 146: 481-486.
17. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997: 88: 553-560.
18. Guthmiller JM, Vargas KG, Srikantha R, et al. Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother 2001: 45: 3216-3219.
19. Harder J, Siebert R, Zhang Y, et al. Mapping of the gene encoding human β-defensin-2 (DEFB2) to chromosome region 8p22-p23.1. Genomics 1997: 46: 472-475.
20. Harder J, Meyer-Hoffert U, Teran LM, et al. Mucoid Pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6, induce human β-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000: 22: 714-721.
21. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001: 276: 5707-5713.
22. Hiratsuka T, Nakazato M, Date Y, et al. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 1998: 249: 943-947.
23. Islam D, Bandholtz L, Nilsson J, et al. Down-regulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 2001: 7: 180-185.
24. Jia HP, Schutte BC, Schudy A, et al. Discovery of new human β-defensins using a genomics-based approach. Gene 2001: 263: 211-218.
25. Johnson GK, Organ CC. Prostaglandin E2 and interleukin-1 concentrations in nicotine-exposed oral keratinocyte cultures. J Periodontal Res 1997: 32: 447-454.
26. Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA. Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 1998: 66: 4222-4228.
27. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human β-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000: 68: 2907-2915.
28. Krisanaprakornkit S, Kimball JR, Dale BA. Regulation of human β-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-κB transcription factor family. J Immunol 2002: 168: 316-324.
29. Lehrer RI, Ganz T. Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides. Ann N Y Acad Sci 1996: 797: 228-239.
30. Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997: 94: 14614-14619.
31. Liu L, Wang L, Jia HP, et al. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation. Gene 1998: 222: 237-244.
32. Lockhart SR, Joly S, Vargas K, Swails-Wenger J, Enger L, Soll DR. Natural defenses against Candida colonization breakdown in the oral cavities of the elderly. J Dent Res 1999: 78: 857-868.
33. Mathews M, Jia HP, Guthmiller JM, et al. Production of β-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 1999: 67: 2740-2745.
34. McCray PB Jr, Bentley L. Human airway epithelia express a β-defensin. Am J Respir Cell Mol Biol 1997: 16: 343-349.
35. Ohmori Y, Schreiber RD, Hamilton TA. Synergy between interferon-gamma and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J Biol Chem 1997: 272: 14899-14907.
36. O'Neil DA, Porter EM, Elewaut D, et al. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999: 163: 6718-6724.
37. Ouellette AJ. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol 1999: 277: G257-G261.
38. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor α. Infect Immun 1996: 64: 1565-1568.
39. Sahasrabudhe KS, Kimball JR, Morton TH, Weinberg A, Dale BA. Expression of the antimicrobial peptide, human β-defensin 1, in duct cells of minor salivary glands and detection in saliva. J Dent Res 2000: 79: 1669-1674.
40. Schonwetter BS, Stolzenberg ED, Zasloff MA. Epithelial antibiotics induced at sites of inflammation. Science 1995: 267: 1645-1648.
41. Schutte BC, McCray PB, Jr. [β]-defensins in lung host defense. Annu Rev Physiol 2002: 64: 709-748.
42. Schutte BC, Mitros JP, Bartlett JA, et al. Discovery of five conserved β-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 2002: 99: 2129-2133.
43. Scott MG, Buurman WA, Hancock RE, Gold MR. Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to lipopolysaccharide binding protein. J Immunol 2000: 164: 549-553.
44. Selsted ME, Tang YQ, Morris WL, et al. Purification, primary structures, and antibacterial activities of β-defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem 1993: 268: 6641-6648.
45. Semple CA, Rolfe M, Dorin JR. Duplication and selection in the evolution of primate β-defensin genes. Genome Biol 2003: 4 (5):R31.1-11.
46. Singh PK, Jia HP, Wiles K, et al. Production of β-defensins by human airway epithelia. Proc Natl Acad Sci USA 1998: 95: 14961-14966.
47. Singh PK, Tack BF, McCray PB Jr, Welsh MJ. Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol 2000: 279: L799-L805.
48. Smith KA. Interleukin-2: inception, impact, and implications. Science 1988: 240: 1169-1769.
49. Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M. Epithelial antibiotic induced in states of disease Proc Natl Acad Sci USA 1997: 94: 8686-8690.
50. Tani K, Murphy WJ, Chertov O, et al. Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens. Int Immunol 2000: 12: 691-700.
51. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Jr, Ganz T. Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998: 101: 1633-1642.
52. Yang D, Chertov O, Bykovskaia SN, et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999: 286: 525-528.
53. Zhao C, Wang I, Lehrer RI. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996: 396: 319-322.
54. Zhao C, Nguyen T, Liu L, Shamova O, Brogden K, Lehrer RI. Differential expression of caprine β-defensins in digestive and respiratory tissues. Infect Immun 1999: 67: 6221-6224.
55. Zimmermann GR, Legault P, Selsted ME, Pardi A. Solution structure of bovine neutrophil β-defensin-12: the peptide fold of the β-defensins is identical to that of the classical defensins. Biochemistry 1995: 34: 13663-13671.