Chronic ethanol intake promotes double gluthatione S-transferase/transforming growth factor-α-positive hepatocellular lesions in male Wistar rats

Cancer Science

Volumn 99, Issue 2, 2008, Pages 221-228

  Pires, Paulo Wagner ^a,b   Furtado, Kelly Silva ^b   Justullin Jr , Luis Antonio ^a,b   Rodrigues, Maria Aparecida Marchesan ^b   Felisbino, Sergio Luis ^b   Barbisan, Luis Fernando ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYCLINE; DIETHYLNITROSAMINE; DRINKING WATER; GELATINASE A; GELATINASE B; GLUTATHIONE TRANSFERASE; MALTODEXTRIN; N (2 FLUORENYL)ACETAMIDE; TAP WATER; TRANSFORMING GROWTH FACTOR ALPHA;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; WISTAR RAT; ZYMOGRAPHY;

ANIMALS; APOPTOSIS; ETHANOL; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PRECANCEROUS CONDITIONS; RATS; RATS, WISTAR; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 38949198670     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2007.00677.x     Document Type: Article

References (48)

1. Pöschl G, Seitz HK. Alcohol and cancer. Alcohol Alcohol 2004; 39: 155-65.
2. Bofetta P, Hashibe M. Alcohol and cancer. Lancet Oncol 2006; 7: 149-56.
3. Brown LM. Epidemiology of alcohol-associated cancers. Alcohol 2005; 35: 161-8.
4. Voight MD. Alcohol in hepatocellular cancer. Clin Liver Dis 2005; 9: 151-69.
5. Vidal F, Toda R, Gutiérrez C et al. Influence of chronic alcohol abuse and liver disease on hepatic aldehyde dehydrogenase activity. Alcohol 1998; 15: 3-8.
6. Lieber CS, Abittan CS. Pharmacology and metabolism of alcohol, including its metabolics effects and interactions with other drugs. Clin Dermatol 1999; 17: 365-79.
7. Bunout D. Nutritional and metabolic effects of alcoholism: Their relationship with alcoholic liver disease. Nutrition 1999; 15: 583-9.
8. Niemellä O. Distribution of ethanol-induced protein adducts in vivo: Relationship to tissue injury. Free Rad Biol Med 2001; 31: 1533-8.
9. Brooks TJ, Theruvathu JA. DNA adducts from acetaldehyde: Implications for alcohol-related carcinogenesis. Alcohol 2005; 35: 187-93.
10. Verna L, Whysner J, Williams GM. N-Nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-Adduct formation, mutagenicity and tumor initiation. Pharmacol Ther 1996; 71: 57-81.
11. Friedman SL. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implication. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 98-105.
12. Purohit V, Brenner DA. Mechanisms of alcohol-induced hepatic fibrosis: A summary of the Ron Thurman symposium. Hepatology 2006; 43: 872-8.
13. Arthur MJP. Fibrogenesis: Metalloproteinases and their inhibitors in liver fibrosis. Am J Physiol Gastrointest Liver Phisiol 2000; 279: 245-9.
14. Tatsuta M, Iishi H, Baba M et al. Enhancement by ethyl alcohol experimental hepatocarcinogenesis induced by N-nitrosomorpholine. Int J Cancer 1997; 71: 1045-8.
15. Karim MR, Wanibuchi H, Wei M, Morimura K, Salim E, Fukushima S. Enhancing risk of ethanol on MeIQx-induced rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress. Cancer Lett 2003; 192: 37-47.
16. Kushida M, Wanibuchi H, Morimura K et al. Dose-dependence of promotion of 2-amino-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: Evidence for a threshold. Cancer Sci 2005; 96: 747-57.
17. Stickel F, Schuppan D, Hahn EG, Seitz HK. Cocarcinogenic effects of alcohol in hepatocarcinogenesis. Gut 2002; 51: 132-9.
18. Croager EJ, Smith PGJ, Yeoh GCT. Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver. Carcinogenesis 2002; 23: 1685-93.
19. Wanibuchi H, Wei M, Karim R et al. Existence of no hepatocarcinogenic effect levels of 2-amino-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol. Toxicol Pathol 2006; 34: 232-6.
20. Yanagi S, Yamashita M, Hiasa Y, Kamiya T. Effect of ethanol on hepatocarcinogenesis initiated in rats with 3′-methyl-4-dimethylaminoazobenzene in the absence of liver injuries. Int J Cancer 1989; 44: 681-4.
21. Cho KJ, Jang JJ. Effects of carbon tetrachloride, ethanol, and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats. Cancer Lett 1993; 70: 33-9.
22. Holmberg B, Ekstrom T. The effects of long-term oral administration of ethanol on Sprague-Dawley rats - a condensed report. Toxicology 1995; 96: 133-45.
23. Solt D, Farber E. New principles for the analysis of chemical carcinogenesis. Nature 1976; 263: 701-3.
24. Semple-Roberts E, Hayes MA, Armstrong D, Becker RA, Racz WJ, Farber E. Alternative methods of selecting hepatocellular nodules resistant to 2-acetylaminefluorene. Int J Cancer 1987; 40: 643-5.
25. Tatematsu M, Nagamine Y, Farber E. Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver. Cancer Res 1983; 43: 5049-58.
26. Wood GA, Sarma DSR, Archer MC. Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats. Carcinogenesis 1999; 20: 1169-75.
27. Bannasch P, Zerban H. Predictive value of hepatic preneoplastic lesions as indicators of carcinogenic response. In: Vainio H, Magee PN, McGregor DB, McMichal AJ, eds. Mechanism of Carcinogenesis in Risk Identification. Lyon: IARC. Sci Publications, no. 116 1992; 389-427.
28. Pinheiro F, Faria RR, de Camargo JL, Spinardi-Barbisan AL, da Eira EF, Barbisan LF. Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat. Food Chem Toxicol 2003; 41: 1543-50.
29. Schulte-Hermann R, Kraupp-Grasl B, Bursch W, Gerbracht U, Timmermann-Trosiener I. Effects of non-genotoxic hepatocarcinogens phenobarbital and nafenopin on phenotype and growth of different populations of altered foci in rat liver. Toxicol Pathol 1989; 17: 642-9.
30. Levin S, Bucci TJ, Cohen SM et al. The nomenclature of cell death: recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists. Toxicol Pathol 1999; 27: 484-90.
31. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
32. Bitsch A, Hadjiolov N, Klöhn P-C, Bergmann O, Zwwirner-Baier I, Neumann H-G. Dose-response of early effects related to tumor promotion of 2-acetylaminofluorene. Toxicol Sci 2000; 55: 44-51.
33. Imai T, Masui T, Ichinose M et al. Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization. Carcinogenesis 1997; 18: 545-51.
34. De Miglio MR, Simile MM, Muroni MR et al. Phenotypic reversion of rat neoplastic liver nodules is under genetic control. Int J Cancer 2003; 105: 70-5.
35. Kaufmann WK, Zhang Y, Kaufmann DG. Association between expression of transforming growth factor-alpha and progression of hepatocellular foci to neoplasms. Carcinogenesis 1992; 13: 1481-3.
36. Tamano S, Merlino GT, Ward JM. Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital. Carcinogenesis 1994; 15: 1791-8.
37. Burr AW, Toole K, Mathew J, Hines JE, Chapman C, Burt AD. Transforming growth factor-α expression is altered during experimental hepatocarcinogenesis. J Pathol 1996; 179: 276-82.
38. Kitano M, Wada J, Ariki Y et al. Possible tumour development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis. Cancer Sci 2006; 97: 478-83.
39. Sandgren EP, Luetteke NC, Qiu TH, Palmiter RD, Brinster RL, Lee DC. Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol Cell Biol 1993; 13: 320-30.
40. Thorgeirsson SS, Santoni-Rugiu E. Transgenic mouse models in carcinogenesis: Interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis. Br J Clin Pharmacol 1996; 42: 43-52.
41. Kato J, Sato Y, Inui N et al. Ethanol induces transforming-growth factor-α expression in hepatocytes, leading to a stimulation of collagen synthesis by hepatic stellate cells. Alcohol Clin Exp Res 2003; 27: 58S-63S.
42. Zerban H, Radig S, Kopp-Schneider A, Bannasch P. Cell proliferation and cell death (apoptosis) in hepatic preneoplasia and neoplasia are closely related to phenotypic cellular diversity and instability. Carcinogenesis 1994; 15: 2467-73.
43. Grasl-Kraupp B, Ruttkay-Nedecky B, Müllauer H, Taper H, Huber W, Bursch W. Schulte-Hermann R Inherent increase of apoptosis in liver tumors: Implications for carcinogenesis and tumor regression. Hepatology 1997; 25: 906-12.
44. Tanaka T, Hirota Y, Kuriyama M, Nishiguchi S, Otani S. Time course of change in glutathione s-transferase positive foci and ornithine decarboxylase activity after cessation of long-term alcohol administration in rats. Asian Pac J Cancer Prev 2001; 2: 131-4.
45. Mazzantini RP, de Conti A, Moreno FS. Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways. J Cell Biochem 2007.
46. Foda HD, Zucker S. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov Today 2001; 6: 478-82.
47. Aye MM, Cuiling MA, Lin H, Bower KA, Wiggins RC, Luo J. Ethanol-induced in vitro invasion of breast cancer cells. the contribution of MMP-2 by fibroblasts. Int J Cancer 2004; 112: 738-46.
48. Ke Z, Lin H, Fan Z et al. MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int J Cancer 2006; 119: 8-16.