Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: Evidence for a threshold

Cancer Science

Volumn 96, Issue 11, 2005, Pages 747-757

  Kushida, Masahiko ^a   Wanibuchi, Hideki ^a   Morimura, Keiichirou ^a   Kinoshita, Anna ^a   Kang, Jin Seok ^a   Puatanachokckai, Rawiwan ^a   Wei, Min ^a   Funae, Yoshihiko ^a   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 8 HYDROXYDEOXYGUANOSINE; ALCOHOL; CYCLIN D1; CYTOCHROME P450 2E1; GLUTATHIONE TRANSFERASE; MESSENGER RNA; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INCIDENCE; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TUMOR PROMOTION; WESTERN BLOTTING;

ADENOMA; ADMINISTRATION, ORAL; ANIMALS; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CYTOCHROME P-450 CYP2E1; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ETHANOL; LIVER NEOPLASMS; MALE; QUINOXALINES; RATS; RATS, INBRED F344; RNA, MESSENGER;

EID: 29644440327     PISSN: 13479032     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2005.00110.x     Document Type: Article

References (45)

1. Poschl G, Seitz HK. Alcohol and cancer. Alcohol Alcohol 2004; 39: 155-65.
2. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology 2004; 127: S87-96.
3. Anonymous. Do not change the numbers - clarify the message. The government review of the Sensible Drinking message: a Medical Council on Alcoholism view. Alcohol Alcohol 1995; 30: 571-5.
4. Byers T, Nestle M, McTiernan A et al. American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 2002; 52: 92-119.
5. Holmberg B, Ekstrom T. The effects of long-term oral administration of ethanol on Sprague-Dawley rats - a condensed report. Toxicology 1995; 96: 133-45.
6. Tsutsumi M, Matsuda Y, Takada A. Role of ethanol-inducible cytochrome P-450 2E1 in the development of hepatocellular carcinoma by the chemical carcinogen, N-nitrosodimethylamine. Hepatology 1993; 18: 1483-9.
7. Mandl J, Banhegyi G, Garzo T et al. Ethanol treatment inhibits the development of diethylnitrosamine-induced tumors in rats. J Exp Pathol 1989; 4: 227-35.
8. Habs M, Schmahl D. Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats. Hepatogastroenterology 1981; 28: 242-4.
9. Porta EA, Markell N, Dorado RD. Chronic alcoholism enhances hepatocarcinogenicity of diethylnitrosamine in rats fed a marginally methyl-deficient diet. Hepatology 1985; 5: 1120-5.
10. Takada A, Nei J, Takase S, Matsuda Y. Effects of ethanol on experimental hepatocarcinogenesis. Hepatology 1986; 6: 65-72.
11. Tanaka T, Nishikawa A, Iwata H et al. Enhancing effect of ethanol on aflatoxin B1-induced hepatocarcinogenesis in male ACI/N rats. Jpn J Cancer Res 1989; 80: 526-30.
12. Mufti SI, Sipes IG. A reduction in mixed function oxidases and in tumor promoting effects of ethanol in a NDEA-initiated hepatocarcinogenesis model. Adv Exp Med Biol 1991; 283: 347-52.
13. Karim MR, Wanibuchi H, Wei M et al. Enhancing risk of ethanol on MeIQx-induced rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress. Cancer Lett 2003; 192: 37-47.
14. Fukushima S, Wanibuchi H, Morimura K et al. Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett 2003; 191: 35-40.
15. Sugimura T. Studies on environmental chemical carcinogenesis in Japan. Science 1986; 233: 312-8.
16. Kushida H, Wakabayashi K, Sato H et al. Dose-response study of MeIQx carcinogenicity in F344 male rats. Cancer Lett 1994; 83: 31-5.
17. Kitano M, Ichihara T, Matsuda T et al. Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat. Carcinogenesis 1998; 19: 1475-80.
18. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
19. Matsuda T, Imaoka S, Funae Y, Otori K, Fukushima S. Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or beta-naphthoflavone. Cancer Lett 1995; 97: 137-43.
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
21. Kushida M, Sukata T, Uwagawa S et al. Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: Possible mechanisms. Toxicol Appl Pharmacol 2005.
22. Kinoshita A, Wanibuchi H, Imaoka S et al. Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21 (WAF1/Cip1), cyclin D1 and Ogg1. Carcinogenesis 2002; 23: 341-9.
23. Kang JS, Wanibuchi H, Morimura K et al. Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats. Toxicol Sci 2005; 85: 720-6.
24. Shibayama Y, Nishijima A, Asaka S, Nakata K. Influence of chronic alcohol consumption on the development of altered hepatocellular foci in rats. Exp Toxicol Pathol 1993; 45: 15-9.
25. Kato R, Yamazoe Y. Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates. Jpn J Cancer Res 1987; 78: 297-311.
26. Yanagawa Y, Sawada M, Deguchi T, Gonzalez FJ, Kamataki T. Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline. Cancer Res 1994; 54: 3422-7.
27. Gouillon ZQ, Miyamoto K, Donohue TM et al. Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway. Front Biosci 1999; 4: A16-25.
28. Chung J, Liu C, Smith DE et al. Restoration of retinoic acid concentration suppresses ethanol-enhanced c-Jun expression and hepatocyte proliferation in rat liver. Carcinogenesis 2001; 22: 1213-9.
29. Chung J, Chavez PR, Russell RM, Wang XD. Retinoic acid inhibits hepatic Jun N-terminal kinase-dependent signaling pathway in ethanol-fed rats. Oncogene 2002; 21: 1539-47.
30. Baroni GS, Marucci L, Benedetti A et al. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol 1994; 20: 508-13.
31. Farber E. Hepatocyte proliferation in stepwise development of experimental liver cell cancer. Dig Dis Sci 1991; 36: 973-8.
32. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-19.
33. Korsmeyer SJ. BCL-2 gene family and the regulation of programmed cell death. Cancer Res 1999; 59: 1693s-1700s.
34. Lian F, Chung J, Russell RM, Wang XD. Alcohol-reduced plasma IGF-I levels and hepatic IGF-I expression can be partially restored by retinoic acid supplementation in rats. J Nutr 2004; 134: 2953-6.
35. Park SH, Heo JS, Kang CW. Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats. Clin Exp Pharmacol Physiol 2004; 31: 22-8.
36. Grasl-Kraupp B, Bursch W, Ruttkay-Nedecky B et al. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc Natl Acad Sci USA 1994; 91: 9995-9.
37. Wang GS, Olsson JM, Eriksson LC, Stal P. Diet restriction increases ubiquinone contents and inhibits progression of hepatocellular carcinoma in the rat. Scand J Gastroenterol 2000; 35: 83-9.
38. Hodgson DM, Chiappelli F, Morrow NS, Taylor AN. Chronic dietary restriction influences tumor metastasis in the rat: parametric considerations. Nutr Cancer 1997; 28: 189-98.
39. Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 1997; 77: 517-44.
40. Novak RF, Woodcroft KJ. The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression. Arch Pharm Res 2000; 23: 267-82.
41. Roberts BJ, Song BJ, Soh Y, Park SS, Shoaf SE. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem 1995; 270: 29632-5.
42. Bardag-Gorce F, Li J, French BA, French SW. Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341. Free Radic Biol Med 2002; 32: 17-21.
43. Bardag-Gorce F, Yuan QX, Li J et al. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 2000; 279: 23-9.
44. Howard LA, Micu AL, Sellers EM, Tyndale RF. Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. J Pharmacol Exp Ther 2001; 299: 542-50.
45. Stickel F, Schuppan D, Hahn EG, Seitz HK. Cocarcinogenic effects of alcohol in hepatocarcinogenesis. Gut 2002; 51: 132-9.