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Volumn 1054, Issue , 2005, Pages 124-135

Objectives and mechanism of iron chelation therapy

Author keywords

Deferiprone; Deferoxamine; ICL670; Iron chelation; NTBI; Thalassemia

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DEFERRIFERRITHIOCIN; IRON CHELATING AGENT;

EID: 29744458330     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1345.015     Document Type: Conference Paper
Times cited : (70)

References (38)
  • 1
    • 0036800592 scopus 로고    scopus 로고
    • A genetic view of iron homeostasis
    • ANDREWS, N.C. 2002. A genetic view of iron homeostasis. Semin. Hematol. 39: 227-234.
    • (2002) Semin. Hematol. , vol.39 , pp. 227-234
    • Andrews, N.C.1
  • 2
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • GANZ, T. 2003. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102: 783-788.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 4
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity
    • HERSHKO, C., G. GRAHAM, G.W. BATES & E.A. RACHMILEWITZ. 1978. Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br. J. Haematol. 40: 255-263.
    • (1978) Br. J. Haematol. , vol.40 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.W.3    Rachmilewitz, E.A.4
  • 6
    • 0029978555 scopus 로고    scopus 로고
    • Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy
    • PORTER, J.B., R.D. ABEYSINGHE, L. MARSHALL, et al. 1996. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood 88: 705-713.
    • (1996) Blood , vol.88 , pp. 705-713
    • Porter, J.B.1    Abeysinghe, R.D.2    Marshall, L.3
  • 7
    • 0022111669 scopus 로고
    • Heart cells in culture: A model of myocardial iron overload and chelation
    • LINK, G., A. PINSON & C. HERSHKO. 1985. Heart cells in culture: a model of myocardial iron overload and chelation. J. Lab. Clin. Med. 106: 147-153.
    • (1985) J. Lab. Clin. Med. , vol.106 , pp. 147-153
    • Link, G.1    Pinson, A.2    Hershko, C.3
  • 8
    • 0024532167 scopus 로고
    • Effect of iron loading on transmembrane potential, contraction and automaticity of rat ventricular muscle cells in culture
    • LINK, G., P. ATHIAS, A. GRYNBERG, et al. 1989. Effect of iron loading on transmembrane potential, contraction and automaticity of rat ventricular muscle cells in culture. J. Lab. Clin. Med. 113: 103-111.
    • (1989) J. Lab. Clin. Med. , vol.113 , pp. 103-111
    • Link, G.1    Athias, P.2    Grynberg, A.3
  • 9
    • 0029937713 scopus 로고    scopus 로고
    • Dynamics of the cytosolic chelatable iron pool of K562 cells
    • BREUER, W., S. EPSZTEJN & Z.I. CABANTCHIK. 1997. Dynamics of the cytosolic chelatable iron pool of K562 cells. FEBS Lett. 382: 304-308.
    • (1997) FEBS Lett. , vol.382 , pp. 304-308
    • Breuer, W.1    Epsztejn, S.2    Cabantchik, Z.I.3
  • 12
    • 0025754836 scopus 로고
    • Expression of the genes for the ferritin H and L subunits in rat liver and heart. Evidence for tissue-specific regulations at pre- and post-translational levels
    • CAIRO, G., E. RAPPOCCIOLO, L. TACCHINI & L. SCHIAFFONATI. 1991. Expression of the genes for the ferritin H and L subunits in rat liver and heart. Evidence for tissue-specific regulations at pre- and post-translational levels. Biochem. J. 275: 813-816.
    • (1991) Biochem. J. , vol.275 , pp. 813-816
    • Cairo, G.1    Rappocciolo, E.2    Tacchini, L.3    Schiaffonati, L.4
  • 13
    • 0032078224 scopus 로고    scopus 로고
    • Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells
    • LINK, G., A. SAADA, A. PINSON, et al. 1998. Mitochondrial respiratory enzymes are a major target of iron toxicity in rat heart cells. J. Lab. Clin. Med. 131: 466-474.
    • (1998) J. Lab. Clin. Med. , vol.131 , pp. 466-474
    • Link, G.1    Saada, A.2    Pinson, A.3
  • 14
    • 0028294163 scopus 로고
    • The ability of orally effective iron chelators dimethyl- and diethyl-hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells
    • LINK, G., A. PINSON & C. HERSHKO. 1994. The ability of orally effective iron chelators dimethyl- and diethyl-hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells. Blood 83: 2692-2697.
    • (1994) Blood , vol.83 , pp. 2692-2697
    • Link, G.1    Pinson, A.2    Hershko, C.3
  • 15
    • 0023751318 scopus 로고
    • Effects of acute iron loading on contractility and spontaneous beating rate of cultured rat myocardial cells
    • MOREB, J., C. HERSHKO & Y. HASIN. 1988. Effects of acute iron loading on contractility and spontaneous beating rate of cultured rat myocardial cells. Basic Res. Cardiol. 83: 360-368.
    • (1988) Basic Res. Cardiol. , vol.83 , pp. 360-368
    • Moreb, J.1    Hershko, C.2    Hasin, Y.3
  • 16
    • 3042746877 scopus 로고    scopus 로고
    • Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
    • DAVIS, B.A., C. O'SULLIVAN, P.H. JARRITT, et al. 2004. Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major. Blood 104: 263-269.
    • (2004) Blood , vol.104 , pp. 263-269
    • Davis, B.A.1    O'Sullivan, C.2    Jarritt, P.H.3
  • 17
    • 0034651775 scopus 로고    scopus 로고
    • Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia
    • DAVIS, B.A. & J.B. PORTER. 2000. Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia. Blood 95: 1229-1236.
    • (2000) Blood , vol.95 , pp. 1229-1236
    • Davis, B.A.1    Porter, J.B.2
  • 18
    • 0038133426 scopus 로고    scopus 로고
    • Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation Eur
    • MISKIN, H., I. YANIV, M. BERANT, et al. 2003. Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation Eur. J. Haematol. 70: 398-403.
    • (2003) J. Haematol. , vol.70 , pp. 398-403
    • Miskin, H.1    Yaniv, I.2    Berant, M.3
  • 19
    • 0034631379 scopus 로고    scopus 로고
    • Survival in beta-thalassaemia major in the UK: Data from the UK Thalassaemia Register
    • MODELL, B., M. KHAN & M. DARLISON. 2000. Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 355: 2051-2052.
    • (2000) Lancet , vol.355 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 20
    • 3042758517 scopus 로고    scopus 로고
    • Complications of β-thalassemia major in North America
    • CUNNINGHAM, M.J., E.A. MACKLIN & E.J. NEUFELD. 2004. Complications of β-thalassemia major in North America. Blood 104: 34-39.
    • (2004) Blood , vol.104 , pp. 34-39
    • Cunningham, M.J.1    Macklin, E.A.2    Neufeld, E.J.3
  • 22
    • 0032887235 scopus 로고    scopus 로고
    • Deferiprone. A review of its clinical potential in iron overload in β-thalassaemia major and other transfusion-dependent diseases
    • BARMAN BALFOUR, J.A. & R.H. FOSTER. 1999. Deferiprone. A review of its clinical potential in iron overload in β-thalassaemia major and other transfusion-dependent diseases. Drugs 58: 553-578.
    • (1999) Drugs , vol.58 , pp. 553-578
    • Barman Balfour, J.A.1    Foster, R.H.2
  • 23
    • 0037630378 scopus 로고    scopus 로고
    • Role of deferiprone in chelation therapy for transfusional iron overload
    • HOFFBRAND, A.V., A. COHEN & C. HERSHKO. 2003. Role of deferiprone in chelation therapy for transfusional iron overload. Blood 102: 17-24.
    • (2003) Blood , vol.102 , pp. 17-24
    • Hoffbrand, A.V.1    Cohen, A.2    Hershko, C.3
  • 24
    • 18444390877 scopus 로고    scopus 로고
    • Deferiprone versus deferoxamine in patients with thalassemia major: A randomized clinical trial
    • MAGGIO, A., G. D'AMICO, A. MORABITO, et al. 2002. Deferiprone versus deferoxamine in patients with thalassemia major: a randomized clinical trial. Blood Cells Mol. Dis. 28: 196-208.
    • (2002) Blood Cells Mol. Dis. , vol.28 , pp. 196-208
    • Maggio, A.1    D'Amico, G.2    Morabito, A.3
  • 25
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
    • PIGA, A., C. GAGLIOTI, E. FOGLIACCO, et al. 2003. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica 88: 489-496.
    • (2003) Haematologica , vol.88 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3
  • 26
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia
    • ANDERSON, L.J., B. WONKE, E. PRESCOTT, et al. 2002. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia. Lancet 360: 516-520.
    • (2002) Lancet , vol.360 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3
  • 27
    • 0027433891 scopus 로고
    • Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3- hydroxypyrid-4-one, CP94, relates to different metabolism of the iron chelating site
    • PORTER, J.B., R.D. ABEYSINGHE, K.P. HOYES, et al. 1993. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyrid-4-one, CP94, relates to different metabolism of the iron chelating site. Br. J. Haematol. 85: 159-168.
    • (1993) Br. J. Haematol. , vol.85 , pp. 159-168
    • Porter, J.B.1    Abeysinghe, R.D.2    Hoyes, K.P.3
  • 28
    • 0027486590 scopus 로고
    • Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools
    • HOYES, K.P. & J.B. PORTER. 1993. Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools. Br. J. Haematol. 85: 393-400.
    • (1993) Br. J. Haematol. , vol.85 , pp. 393-400
    • Hoyes, K.P.1    Porter, J.B.2
  • 29
    • 0025817843 scopus 로고
    • Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: Studies in rat heart cells in culture
    • HERSHKO, C., G. LINK, A. PINSON, et al. 1991. Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture. Blood 77: 2049-2053.
    • (1991) Blood , vol.77 , pp. 2049-2053
    • Hershko, C.1    Link, G.2    Pinson, A.3
  • 30
    • 0028962119 scopus 로고
    • Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload
    • AL-REFAIE, F.N., L.N. SHEPPARD, P. NORTEY, et al. 1995. Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload Br. J. Haematol. 89: 403-407.
    • (1995) Br. J. Haematol. , vol.89 , pp. 403-407
    • Al-Refaie, F.N.1    Sheppard, L.N.2    Nortey, P.3
  • 31
    • 0032055861 scopus 로고    scopus 로고
    • Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload disease
    • RICHARDSON, D.R. & P. PONKA. 1998. Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. J. Lab. Clin. Med. 131: 306-314.
    • (1998) J. Lab. Clin. Med. , vol.131 , pp. 306-314
    • Richardson, D.R.1    Ponka, P.2
  • 32
    • 0037906104 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron-overload due to beta-thalassemia
    • GALANELLO, R., A. PIGA, D. ALBERTI, et al. 2003. Safety, tolerability and pharmacokinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron-overload due to beta-thalassemia. J. Clin. Pharmacol. 43: 565-572.
    • (2003) J. Clin. Pharmacol. , vol.43 , pp. 565-572
    • Galanello, R.1    Piga, A.2    Alberti, D.3
  • 33
    • 0042309610 scopus 로고    scopus 로고
    • Structure-activity relationships among desazadesferrithiocin analogues
    • BERGERON, R.J., J. WIEGAND, J.S. MCMANIS, et al. 2002. Structure-activity relationships among desazadesferrithiocin analogues. Adv. Exp. Med. Biol. 509: 167-184.
    • (2002) Adv. Exp. Med. Biol. , vol.509 , pp. 167-184
    • Bergeron, R.J.1    Wiegand, J.2    Mcmanis, J.S.3
  • 34
    • 0035254193 scopus 로고    scopus 로고
    • Deferoxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy
    • BREUER, W., M.J. EMPERS, P. POOTRAKUL, et al. 2001. Deferoxamine- chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy. Blood 97: 792-798.
    • (2001) Blood , vol.97 , pp. 792-798
    • Breuer, W.1    Empers, M.J.2    Pootrakul, P.3
  • 35
    • 0031784438 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine
    • WONKE, B., C. WRIGHT & A.V. HOFFBRAND. 1998. Combined therapy with deferiprone and desferrioxamine. Br. J. Haematol. 103: 361-364.
    • (1998) Br. J. Haematol. , vol.103 , pp. 361-364
    • Wonke, B.1    Wright, C.2    Hoffbrand, A.V.3
  • 36
    • 0003291393 scopus 로고    scopus 로고
    • Oral iron chelation: A potential role for HBED in combination therapy. American Society of Hematology, 41st Annual Meeting. December 1999
    • Abstr. 3293
    • GRADY, R.W. & P.J. GIARDINA. 1999. Oral iron chelation: a potential role for HBED in combination therapy. American Society of Hematology, 41st Annual Meeting. December 1999. Blood 94(Suppl. 1): Abstr. 3293.
    • (1999) Blood , vol.94 , Issue.SUPPL. 1
    • Grady, R.W.1    Giardina, P.J.2
  • 37
    • 0036068230 scopus 로고    scopus 로고
    • The safety and effectiveness of deferiprone in a large-scale 3-year study in Italian patients
    • CECI, A., P. BAIARDI, M. FELISI, et al. 2002. The safety and effectiveness of deferiprone in a large-scale 3-year study in Italian patients. Br. J. Haematol. 118: 330-336.
    • (2002) Br. J. Haematol. , vol.118 , pp. 330-336
    • Ceci, A.1    Baiardi, P.2    Felisi, M.3
  • 38
    • 0031985039 scopus 로고    scopus 로고
    • Long-term trial of deferiprone in transfusion-dependent iron overloaded patients
    • HOFFBRAND, A.V., F. AL-REFAIE, B. DAVIS, et al. 1998. Long-term trial of deferiprone in transfusion-dependent iron overloaded patients. Blood 91: 295-300.
    • (1998) Blood , vol.91 , pp. 295-300
    • Hoffbrand, A.V.1    Al-Refaie, F.2    Davis, B.3


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