메뉴 건너뛰기




Volumn 45, Issue 1, 2008, Pages 9-18

Three generations of ongoing controversies concerning the use of short acting beta-agonist therapy in asthma: A review

Author keywords

Adrenergic; Adrenergic beta agonists; Albuterol enantiomers; Asthma; Beta; Genotype; Receptors

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; FENOTEROL; IPRATROPIUM BROMIDE; ISOPRENALINE; LEVALBUTEROL; PREDNISONE; SALBUTAMOL; SHORT ACTING DRUG;

EID: 38949182970     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.1080/02770900701495512     Document Type: Review
Times cited : (4)

References (79)
  • 1
    • 0014408297 scopus 로고
    • Observations on recent increase in mortality from asthma
    • Speizer FE, Doll R, Heaf P. Observations on recent increase in mortality from asthma. BMJ 1968; 1:335-339.
    • (1968) BMJ , vol.1 , pp. 335-339
    • Speizer, F.E.1    Doll, R.2    Heaf, P.3
  • 2
    • 0029924030 scopus 로고    scopus 로고
    • Partial versus full beta-receptor agonism. A clinical study of inhaled albuterol and fenoterol
    • Bremner P, Siebers R, Crane J, Beasley R, Burgess C. Partial versus full beta-receptor agonism. A clinical study of inhaled albuterol and fenoterol. Chest 1996; 109:957-962.
    • (1996) Chest , vol.109 , pp. 957-962
    • Bremner, P.1    Siebers, R.2    Crane, J.3    Beasley, R.4    Burgess, C.5
  • 3
    • 0015348479 scopus 로고
    • Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma
    • Stolley PD. Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma. Am Rev Respir Dis. 1972; 105:883-890.
    • (1972) Am Rev Respir Dis , vol.105 , pp. 883-890
    • Stolley, P.D.1
  • 4
    • 0018246383 scopus 로고
    • Association between asthma mortality and isoproterenol aerosols: A review
    • Stolley PD, Schinnar R. Association between asthma mortality and isoproterenol aerosols: a review. Prev Med. 1978; 7:519-538.
    • (1978) Prev Med , vol.7 , pp. 519-538
    • Stolley, P.D.1    Schinnar, R.2
  • 5
    • 29544434127 scopus 로고    scopus 로고
    • A historical perspective of the New Zealand asthma mortality epidemics
    • Beasley R. A historical perspective of the New Zealand asthma mortality epidemics. J Allergy Clin Immunol. 2006; 117:225-228.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 225-228
    • Beasley, R.1
  • 7
    • 0029023461 scopus 로고
    • Changing patterns in asthma morbidity and mortality
    • Sears MR. Changing patterns in asthma morbidity and mortality. J Investig Allergol Clin Immunol. 1995; 5:66-72.
    • (1995) J Investig Allergol Clin Immunol , vol.5 , pp. 66-72
    • Sears, M.R.1
  • 9
    • 0029834111 scopus 로고    scopus 로고
    • Confounding by indication and channeling over time: The risks of beta 2-agonists
    • Blais L, Ernst P, Suissa S. Confounding by indication and channeling over time: the risks of beta 2-agonists. Am J Epidemiol. 1996; 144:1161-1169.
    • (1996) Am J Epidemiol , vol.144 , pp. 1161-1169
    • Blais, L.1    Ernst, P.2    Suissa, S.3
  • 10
    • 0034601431 scopus 로고    scopus 로고
    • Low dose inhaled corticosteroids and the prevention of death from asthma
    • Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B. Low dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med. 2000; 343:332-336.
    • (2000) N Engl J Med , vol.343 , pp. 332-336
    • Suissa, S.1    Ernst, P.2    Benayoun, S.3    Baltzan, M.4    Cai, B.5
  • 11
    • 38949206099 scopus 로고    scopus 로고
    • Barnes PJ. Rebuttal by Dr. Barnes. Am J Respir Crit Care Med. 2006; 174(9):974.
    • Barnes PJ. Rebuttal by Dr. Barnes. Am J Respir Crit Care Med. 2006; 174(9):974.
  • 12
    • 0032888402 scopus 로고    scopus 로고
    • Beta-agonists: What is the evidence that their use increases the risk of asthma morbidity and mortality?
    • Beasley R, Pearce N, Crane J, Burgess C. Beta-agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality? J Allergy Clin Immunol. 1999; 104(2 Pt 2):S18-S30.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.2 PART 2
    • Beasley, R.1    Pearce, N.2    Crane, J.3    Burgess, C.4
  • 13
    • 0028169718 scopus 로고
    • The beta 2-agonist controversy. Observations, explanations and relationship to asthma epidemiology
    • Sears MR, Taylor DR. The beta 2-agonist controversy. Observations, explanations and relationship to asthma epidemiology. Drug Saf. 1994; 11:259-283.
    • (1994) Drug Saf , vol.11 , pp. 259-283
    • Sears, M.R.1    Taylor, D.R.2
  • 14
    • 0028363250 scopus 로고
    • Regular versus as-needed inhaled salbutamol in asthma control
    • Chapman KR, Kesten S, Szalai JP. Regular versus as-needed inhaled salbutamol in asthma control. Lancet 1994; 343:1379-1382.
    • (1994) Lancet , vol.343 , pp. 1379-1382
    • Chapman, K.R.1    Kesten, S.2    Szalai, J.P.3
  • 16
    • 2442552858 scopus 로고    scopus 로고
    • Meta-analysis: Respiratory tolerance to regular beta2-agonist use in patients with asthma
    • Salpeter SR, Ormiston TM, Salpeter EE. Meta-analysis: respiratory tolerance to regular beta2-agonist use in patients with asthma. Ann Intern Med. 2004; 140:802-813.
    • (2004) Ann Intern Med , vol.140 , pp. 802-813
    • Salpeter, S.R.1    Ormiston, T.M.2    Salpeter, E.E.3
  • 17
    • 0041885456 scopus 로고    scopus 로고
    • Adverse effects of beta-agonists: Are they clinically relevant?
    • Abramson MJ, Walters J, Walters EH. Adverse effects of beta-agonists: are they clinically relevant? Am J Respir Med. 2003; 2:287-297.
    • (2003) Am J Respir Med , vol.2 , pp. 287-297
    • Abramson, M.J.1    Walters, J.2    Walters, E.H.3
  • 18
    • 0027466297 scopus 로고
    • Stereoselective sulphate conjugation of salbutamol in humans: Comparison of hepatic, intestinal and platelet activity
    • Walle UK, Pesola GR, Walle T. Stereoselective sulphate conjugation of salbutamol in humans: comparison of hepatic, intestinal and platelet activity. Br J Clin Pharmacol. 1993; 35:413-418.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 413-418
    • Walle, U.K.1    Pesola, G.R.2    Walle, T.3
  • 19
    • 0029874113 scopus 로고    scopus 로고
    • Stereoselective sulphate conjugation of salbutamol by human lung and bronchial epithelial cells
    • Eaton EA, Walle UK, Wilson HM, Aberg G, Walle T. Stereoselective sulphate conjugation of salbutamol by human lung and bronchial epithelial cells. Br J Clin Pharmacol. 1996; 41:201-206.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 201-206
    • Eaton, E.A.1    Walle, U.K.2    Wilson, H.M.3    Aberg, G.4    Walle, T.5
  • 20
  • 21
    • 0038543534 scopus 로고    scopus 로고
    • Single-isomer levalbuterol: A review of the acute data
    • Nowak R. Single-isomer levalbuterol: a review of the acute data. Curr Allergy Asthma Rep. 2003; 3:172-178.
    • (2003) Curr Allergy Asthma Rep , vol.3 , pp. 172-178
    • Nowak, R.1
  • 22
    • 1542616267 scopus 로고    scopus 로고
    • (S)-Albuterol activates proconstrictory and pro-inflammatory pathways in human bronchial smooth muscle cells
    • Agrawal DK, Ariyarathna K, Kelbe PW. (S)-Albuterol activates proconstrictory and pro-inflammatory pathways in human bronchial smooth muscle cells. J Allergy Clin Immunol. 2004; 113:503-510.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 503-510
    • Agrawal, D.K.1    Ariyarathna, K.2    Kelbe, P.W.3
  • 24
    • 33644839976 scopus 로고    scopus 로고
    • Effects of (R)- and (S)-isomers of beta-adrenergic agonists on eosinophil response to interleukin-5
    • Volcheck GW, Kelkar P, Bartemes KR, Gleich GJ, Kita H. Effects of (R)- and (S)-isomers of beta-adrenergic agonists on eosinophil response to interleukin-5. Clin Exp Allergy 2005; 35:1341-1346.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1341-1346
    • Volcheck, G.W.1    Kelkar, P.2    Bartemes, K.R.3    Gleich, G.J.4    Kita, H.5
  • 25
    • 0032886566 scopus 로고    scopus 로고
    • Contrasting properties of albuterol stereoisomers
    • Page CP, Morley J. Contrasting properties of albuterol stereoisomers. J Allergy Clin Immunol. 1999; 104(2 Pt 2):S31-S41.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.2 PART 2
    • Page, C.P.1    Morley, J.2
  • 26
    • 0346041503 scopus 로고    scopus 로고
    • Distinguishing severe asthma phenotypes. Role of age at onset and eosinophilic inflammation
    • Miranda C, Busacker A, Balzar S, Trudeau J, Wenzel SE. Distinguishing severe asthma phenotypes. Role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol. 2004; 113(1):101-108.
    • (2004) J Allergy Clin Immunol , vol.113 , Issue.1 , pp. 101-108
    • Miranda, C.1    Busacker, A.2    Balzar, S.3    Trudeau, J.4    Wenzel, S.E.5
  • 27
    • 0036907527 scopus 로고    scopus 로고
    • Effects of beta2-agonists on resident and infiltrating inflammatory cells
    • Johnson M. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002; 110:S282-S290.
    • (2002) J Allergy Clin Immunol , vol.110
    • Johnson, M.1
  • 28
    • 0031966248 scopus 로고    scopus 로고
    • (S)-albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle
    • Mitra S, Ugur M, Ugur O. (S)-albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle. Mol Pharmacol. 1998; 53:347-354.
    • (1998) Mol Pharmacol , vol.53 , pp. 347-354
    • Mitra, S.1    Ugur, M.2    Ugur, O.3
  • 29
    • 21344455315 scopus 로고    scopus 로고
    • Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle
    • Ameredes BT, Calhoun WJ. Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle. J Allergy Clin Immunol. 2005; 116:65-72.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 65-72
    • Ameredes, B.T.1    Calhoun, W.J.2
  • 31
    • 38949166564 scopus 로고    scopus 로고
    • S)-Albuterol binds to intracellular organelles and proteins in human airway smooth muscle cells. Am J Respir Crit Care Med
    • abstract
    • Agrawal DK, Kelbe PW. (S)-Albuterol binds to intracellular organelles and proteins in human airway smooth muscle cells. Am J Respir Crit Care Med. 2004; 169:A310.[abstract]
    • (2004) , vol.169
    • Agrawal, D.K.1    Kelbe, P.W.2
  • 33
    • 29944439722 scopus 로고    scopus 로고
    • (R)-albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS
    • Chorley BN, Li Y, Fang S, Park JA, Adler KB. (R)-albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS. Am J Respir Cell Mol Biol. 2006; 34:119-127.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 119-127
    • Chorley, B.N.1    Li, Y.2    Fang, S.3    Park, J.A.4    Adler, K.B.5
  • 34
    • 0035345140 scopus 로고    scopus 로고
    • A retrospective study of risk factors for repeated admissions for asthma in a rural/suburban university hospital
    • Kuo A, Craig TJ. A retrospective study of risk factors for repeated admissions for asthma in a rural/suburban university hospital. J Am Osteopath Assoc. 2001; 101(5 Suppl):S14-S17.
    • (2001) J Am Osteopath Assoc , vol.101 , Issue.5 SUPPL.
    • Kuo, A.1    Craig, T.J.2
  • 36
    • 0141497509 scopus 로고    scopus 로고
    • How do corticosteroids work in asthma?
    • Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med. 2003; 139(5 Pt 1):359-370.
    • (2003) Ann Intern Med , vol.139 , Issue.5 PART 1 , pp. 359-370
    • Barnes, P.J.1    Adcock, I.M.2
  • 38
    • 85058722001 scopus 로고    scopus 로고
    • Eudismic Ratio and Enantiomeric Purity of the Albuterol Distomer
    • Jalba MS. Eudismic Ratio and Enantiomeric Purity of the Albuterol Distomer. J Allergy Clin Immunol. 2004; 114:990-991.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 990-991
    • Jalba, M.S.1
  • 39
    • 0036206870 scopus 로고    scopus 로고
    • Stereoselective pharmacokinetics and pharmacodynamics of anti-asthma agents
    • Vakily M, Mehvar R, Brocks D. Stereoselective pharmacokinetics and pharmacodynamics of anti-asthma agents. Ann Pharmacother. 2002; 36:693-701.
    • (2002) Ann Pharmacother , vol.36 , pp. 693-701
    • Vakily, M.1    Mehvar, R.2    Brocks, D.3
  • 40
    • 0030090125 scopus 로고    scopus 로고
    • Differential responses of asthmatic airways to enantiomers of albuterol. Implications for clinical treatment of asthma
    • Spring;
    • Perrin-Fayolle M, Blum PS, Morley J, Grosclaude M, Chambe MT. Differential responses of asthmatic airways to enantiomers of albuterol. Implications for clinical treatment of asthma. Clin Rev Allergy Immunol. 1996 Spring; 14:139-147.
    • (1996) Clin Rev Allergy Immunol , vol.14 , pp. 139-147
    • Perrin-Fayolle, M.1    Blum, P.S.2    Morley, J.3    Grosclaude, M.4    Chambe, M.T.5
  • 41
    • 0030822364 scopus 로고    scopus 로고
    • Effect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine
    • Cockcroft DW, Swystun VA. Effect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine. Thorax 1997; 52:845-848.
    • (1997) Thorax , vol.52 , pp. 845-848
    • Cockcroft, D.W.1    Swystun, V.A.2
  • 42
    • 0032417246 scopus 로고    scopus 로고
    • Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma
    • Nelson HS, Bensch G, Pleskow WW. Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma. J Allergy Clin Immunol. 1998; 102(6 Pt 1):943-952.
    • (1998) J Allergy Clin Immunol , vol.102 , Issue.6 PART 1 , pp. 943-952
    • Nelson, H.S.1    Bensch, G.2    Pleskow, W.W.3
  • 43
    • 0033056771 scopus 로고    scopus 로고
    • The safety and efficacy of nebulized levalbuterol compared with racemic albuterol and placebo in the treatment of asthma in pediatric patients
    • Gawchik SM, Saccar CL, Noonan M, Reasner DS, DeGraw SS. The safety and efficacy of nebulized levalbuterol compared with racemic albuterol and placebo in the treatment of asthma in pediatric patients. J Allergy Clin Immunol. 1999; 103(4):615-621.
    • (1999) J Allergy Clin Immunol , vol.103 , Issue.4 , pp. 615-621
    • Gawchik, S.M.1    Saccar, C.L.2    Noonan, M.3    Reasner, D.S.4    DeGraw, S.S.5
  • 44
    • 0032783997 scopus 로고    scopus 로고
    • Tolerance to the bronchoprotective effect of beta2-agonists: Comparison of the enantiomers of salbutamol with racemic salbutamol and placebo
    • Cockcroft DW, Davis BE, Swystun VA, Marciniuk DD. Tolerance to the bronchoprotective effect of beta2-agonists: comparison of the enantiomers of salbutamol with racemic salbutamol and placebo. J Allergy Clin Immunol. 1999; 103:1049-1053.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 1049-1053
    • Cockcroft, D.W.1    Davis, B.E.2    Swystun, V.A.3    Marciniuk, D.D.4
  • 45
    • 0032840560 scopus 로고    scopus 로고
    • Bronchoprotective and bronchodilator effects of single doses of (S)-salbutamol, (R)-salbutamol and racemic salbutamol in patients with bronchial asthma
    • Ramsay CM, Cowan J, Flannery E, McLachlan C, Taylor DR. Bronchoprotective and bronchodilator effects of single doses of (S)-salbutamol, (R)-salbutamol and racemic salbutamol in patients with bronchial asthma. Eur J Clin Pharmacol. 1999; 55:353-359.
    • (1999) Eur J Clin Pharmacol , vol.55 , pp. 353-359
    • Ramsay, C.M.1    Cowan, J.2    Flannery, E.3    McLachlan, C.4    Taylor, D.R.5
  • 46
    • 0033944910 scopus 로고    scopus 로고
    • Dose-response evaluation of levalbuterol versus racemic albuterol in patients with asthma
    • Handley DA, Tinkelman D, Noonan M, Rollins TE, Snider ME, Caron J. Dose-response evaluation of levalbuterol versus racemic albuterol in patients with asthma. J Asthma 2000; 37:319-327.
    • (2000) J Asthma , vol.37 , pp. 319-327
    • Handley, D.A.1    Tinkelman, D.2    Noonan, M.3    Rollins, T.E.4    Snider, M.E.5    Caron, J.6
  • 48
    • 0035217690 scopus 로고    scopus 로고
    • Levalbuterol Pediatric Study Group. Low-dose levalbuterol in children with asthma: Safety and efficacy in comparison with placebo and racemic albuterol
    • Milgrom H, Skoner DP, Bensch G, Kim KT, Claus R, Baumgartner RA; Levalbuterol Pediatric Study Group. Low-dose levalbuterol in children with asthma: safety and efficacy in comparison with placebo and racemic albuterol. J Allergy Clin Immunol. 2001; 108:938-945.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 938-945
    • Milgrom, H.1    Skoner, D.P.2    Bensch, G.3    Kim, K.T.4    Claus, R.5    Baumgartner, R.A.6
  • 49
    • 0344825868 scopus 로고    scopus 로고
    • Comparison of racemic albuterol and levalbuterol for treatment of acute asthma
    • Carl JC, Myers TR, Kirchner HL, Kercsmar CM. Comparison of racemic albuterol and levalbuterol for treatment of acute asthma. J Pediatr. 2003; 143:731-736.
    • (2003) J Pediatr , vol.143 , pp. 731-736
    • Carl, J.C.1    Myers, T.R.2    Kirchner, H.L.3    Kercsmar, C.M.4
  • 51
    • 11144272224 scopus 로고    scopus 로고
    • Single-isomer R-salbutamol is not superior to racemate regarding protection for bronchial hyperresponsiveness
    • Sjosward KN, Hmani M, Davidsson A, Soderkvist P, Schmekel B. Single-isomer R-salbutamol is not superior to racemate regarding protection for bronchial hyperresponsiveness. Respir Med. 2004; 98:990-999.
    • (2004) Respir Med , vol.98 , pp. 990-999
    • Sjosward, K.N.1    Hmani, M.2    Davidsson, A.3    Soderkvist, P.4    Schmekel, B.5
  • 52
    • 23044505257 scopus 로고    scopus 로고
    • Levalbuterol versus racemic albuterol in the treatment of acute exacerbation of asthma in children
    • Hardasmalani MD, DeBari V, Bithoney WG, Gold N. Levalbuterol versus racemic albuterol in the treatment of acute exacerbation of asthma in children. Pediatr Emerg Care 2005; 21:415-419.
    • (2005) Pediatr Emerg Care , vol.21 , pp. 415-419
    • Hardasmalani, M.D.1    DeBari, V.2    Bithoney, W.G.3    Gold, N.4
  • 53
    • 21444447142 scopus 로고    scopus 로고
    • Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma
    • Qureshi F, Zaritsky A, Welch C, Meadows T, Burke BL. Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma. Ann Emerg Med. 2005; 46:29-36.
    • (2005) Ann Emerg Med , vol.46 , pp. 29-36
    • Qureshi, F.1    Zaritsky, A.2    Welch, C.3    Meadows, T.4    Burke, B.L.5
  • 54
    • 20444393111 scopus 로고    scopus 로고
    • Comparison of levalbuterol and racemic albuterol combined with ipratropium bromide in acute pediatric asthma: A randomized controlled trial
    • Ralston ME, Euwema MS, Knecht KR, Ziolkowski TJ, Coakley TA, Cline SM. Comparison of levalbuterol and racemic albuterol combined with ipratropium bromide in acute pediatric asthma: a randomized controlled trial. J Emerg Med. 2005; 29:29-35.
    • (2005) J Emerg Med , vol.29 , pp. 29-35
    • Ralston, M.E.1    Euwema, M.S.2    Knecht, K.R.3    Ziolkowski, T.J.4    Coakley, T.A.5    Cline, S.M.6
  • 55
    • 27744454999 scopus 로고    scopus 로고
    • Comparison of racemic albuterol and levalbuterol in the treatment of acute asthma in the ED
    • Schreck DM, Babin S. Comparison of racemic albuterol and levalbuterol in the treatment of acute asthma in the ED. Am J Emerg Med. 2005; 23:842-847.
    • (2005) Am J Emerg Med , vol.23 , pp. 842-847
    • Schreck, D.M.1    Babin, S.2
  • 57
    • 33745694161 scopus 로고    scopus 로고
    • XOPENEX Acute Severe Asthma Study Group. A comparison of levalbuterol with racemic albuterol in the treatment of acute severe asthma exacerbations in adults
    • Nowak R, Emerman C, Hanrahan JP, Parsey MV, Hanania NA, Claus R, Schaefer K, Baumgartner RA; XOPENEX Acute Severe Asthma Study Group. A comparison of levalbuterol with racemic albuterol in the treatment of acute severe asthma exacerbations in adults. Am J Emerg Med. 2006; 24:259-267.
    • (2006) Am J Emerg Med , vol.24 , pp. 259-267
    • Nowak, R.1    Emerman, C.2    Hanrahan, J.P.3    Parsey, M.V.4    Hanania, N.A.5    Claus, R.6    Schaefer, K.7    Baumgartner, R.A.8
  • 58
    • 33745728010 scopus 로고    scopus 로고
    • Xopenex Pediatric Asthma Group. Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: A double-blind, randomized, placebo- and active-controlled trial
    • Berger WE, Milgrom H, Skoner DP, Tripp K, Parsey MV, Baumgartner RA; Xopenex Pediatric Asthma Group. Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trial. Curr Med Res Opin. 2006; 22:1217-26.
    • (2006) Curr Med Res Opin , vol.22 , pp. 1217-1226
    • Berger, W.E.1    Milgrom, H.2    Skoner, D.P.3    Tripp, K.4    Parsey, M.V.5    Baumgartner, R.A.6
  • 59
    • 33847263458 scopus 로고    scopus 로고
    • Comparison of bronchodilator responses of levosalbutamol and salbutamol given via a pressurized metered dose inhaler: A randomized, double blind, single-dose, crossover study
    • Epub Feb 1
    • Jantikar A, Brashier B, Maganji M, Raghupathy A, Mahadik P, Gokhale P, Gogtay J, Salvi S. Comparison of bronchodilator responses of levosalbutamol and salbutamol given via a pressurized metered dose inhaler: a randomized, double blind, single-dose, crossover study. Respir Med. 2007; 101:845-9. Epub 2007 Feb 1.
    • (2007) Respir Med. 2007 , vol.101 , pp. 845-849
    • Jantikar, A.1    Brashier, B.2    Maganji, M.3    Raghupathy, A.4    Mahadik, P.5    Gokhale, P.6    Gogtay, J.7    Salvi, S.8
  • 60
    • 33750576685 scopus 로고    scopus 로고
    • (R)-albuterol for asthma: Pro[a.k.a (S)-albuterol for asthma: Con]
    • Ameredes BT, Calhoun WJ. (R)-albuterol for asthma: Pro[a.k.a (S)-albuterol for asthma: Con] Am J Respir Crit Care Med. 2006; 174:965-969.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 965-969
    • Ameredes, B.T.1    Calhoun, W.J.2
  • 61
    • 33947325045 scopus 로고    scopus 로고
    • Treatment with (R)-albuterol has no advantage over racemic albuterol
    • Barnes, PJ. Treatment with (R)-albuterol has no advantage over racemic albuterol. Am J Respir Crit Care Med. 2006; 174(9):969-972.
    • (2006) Am J Respir Crit Care Med , vol.174 , Issue.9 , pp. 969-972
    • Barnes, P.J.1
  • 62
    • 33747044684 scopus 로고    scopus 로고
    • Milgrom H. Levosalbutamol in the treatment of asthma. Expert Opin Pharmacother. 2006; 7:1659-1668.
    • Milgrom H. Levosalbutamol in the treatment of asthma. Expert Opin Pharmacother. 2006; 7:1659-1668.
  • 64
    • 85047694597 scopus 로고    scopus 로고
    • Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox
    • McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. J Clin Invest. 2003; 112:619-626.
    • (2003) J Clin Invest , vol.112 , pp. 619-626
    • McGraw, D.W.1    Almoosa, K.F.2    Paul, R.J.3    Kobilka, B.K.4    Liggett, S.B.5
  • 65
    • 29544449036 scopus 로고    scopus 로고
    • Molecular Mechanisms of β2-adrenergic receptor function, response and regulation
    • Johnson M. Molecular Mechanisms of β2-adrenergic receptor function, response and regulation. J Allergy Clin Immunol. 2006; 117:18-24.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 18-24
    • Johnson, M.1
  • 67
    • 6944232728 scopus 로고    scopus 로고
    • Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet 2004; 364:1505-1512.
    • Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF Jr, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet 2004; 364:1505-1512.
  • 68
    • 15944375533 scopus 로고    scopus 로고
    • Genetics and the variability of treatment response in asthma
    • Israel E. Genetics and the variability of treatment response in asthma. J Allergy Clin Immunol. 2005; 115(4 Suppl):S532-S538.
    • (2005) J Allergy Clin Immunol , vol.115 , Issue.4 SUPPL.
    • Israel, E.1
  • 69
    • 33644787781 scopus 로고    scopus 로고
    • Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene
    • Cho SH, Oh SY, Bahn JW, Choi JY, Chang YS, Kim YK, Min KU, Kim YY. Association between bronchodilating response to short-acting beta-agonist and non-synonymous single-nucleotide polymorphisms of beta-adrenoceptor gene. Clin Exp Allergy 2005; 35:1162-1167.
    • (2005) Clin Exp Allergy , vol.35 , pp. 1162-1167
    • Cho, S.H.1    Oh, S.Y.2    Bahn, J.W.3    Choi, J.Y.4    Chang, Y.S.5    Kim, Y.K.6    Min, K.U.7    Kim, Y.Y.8
  • 73
    • 85047694895 scopus 로고    scopus 로고
    • Beta-agonists and asthma: Too much of a good thing?
    • Shore SA, Drazen JM. Beta-agonists and asthma: too much of a good thing? J Clin Invest. 2003; 112:495-497.
    • (2003) J Clin Invest , vol.112 , pp. 495-497
    • Shore, S.A.1    Drazen, J.M.2
  • 74
    • 0034093205 scopus 로고    scopus 로고
    • Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor
    • Tepe NM, Liggett SB. Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor. J Recept Signal Transduct Res. 2000; 20:75-85.
    • (2000) J Recept Signal Transduct Res , vol.20 , pp. 75-85
    • Tepe, N.M.1    Liggett, S.B.2
  • 76
    • 18144430985 scopus 로고    scopus 로고
    • Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes
    • Contopoulos-Ioannidis DG, Manoli EN, Ioannidis JP. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol. 2005; 115:963-972.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 963-972
    • Contopoulos-Ioannidis, D.G.1    Manoli, E.N.2    Ioannidis, J.P.3
  • 77
    • 33846925885 scopus 로고    scopus 로고
    • Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity
    • Swift SM, Schwarb MR, Mihlbachler KA, Liggett SB. Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. Am J Respir Cell Mol Biol. 2007; 36:236-243.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 236-243
    • Swift, S.M.1    Schwarb, M.R.2    Mihlbachler, K.A.3    Liggett, S.B.4
  • 78
    • 38949193730 scopus 로고    scopus 로고
    • Lowe KC. Xopenex: The beginning of a new trend in pharmaceutics or all hype ? PharmaNote 2005; 20(8):1-8.
    • Lowe KC. Xopenex: The beginning of a new trend in pharmaceutics or all hype ? PharmaNote 2005; 20(8):1-8.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.