Effects of (R)- and (S)-isomers of β-adrenergic agonists on eosinophil response to interleukin-5

Clinical and Experimental Allergy

Volumn 35, Issue 10, 2005, Pages 1341-1346

  Volcheck, G W ^a   Kelkar, P ^a   Bartemes, K R ^b   Gleich, G J ^a,b,c   Kita, H ^a,b,d  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d MAYO CLINIC ROCHESTER   (United States)

Author keywords

2 agonist; Albuterol; Asthma; Eosinophils; IL 5; Inflammation; Isomer; Superoxide

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYTOCHROME C; INTERLEUKIN 5; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; SALBUTAMOL; SUPEROXIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CELL ACTIVATION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; EOSINOPHIL; HUMAN; HUMAN CELL; INFLAMMATORY CELL; ISOMER; PRIORITY JOURNAL; CELL CULTURE; METABOLISM; STEREOISOMERISM;

1-METHYL-3-ISOBUTYLXANTHINE; ADRENERGIC BETA-AGONISTS; ALBUTEROL; CELLS, CULTURED; EOSINOPHILS; HUMANS; INTERLEUKIN-5; PHOSPHODIESTERASE INHIBITORS; STEREOISOMERISM; SUPEROXIDES;

EID: 33644839976     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02347.x     Document Type: Article

References (32)

1. Frigas E Loegering DA Gleich GJ. Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium. Lab Invest 1980 42: 35 43.
2. Frigas E Loegering DA Solley GO Farrow GM Gleich GJ. Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma. Mayo Clin Proc 1981 56: 345 53.
3. Gleich GJ. Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000 105: 651 63.
4. Robinson DS Hamid Q Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992 326: 298 304.
5. Ohnishi T Kita H Weiler D et al. IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. Am Rev Respir Dis 1993 147: 901 7.
6. Leckie M J ten Brinke A Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 2000 356: 2144 8.
7. Flood-Page PT Menzies-Gow AN Kay AB Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003 167: 199 204.
8. Spitzer WO Suissa S Ernst P et al. The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med 1992 326: 501 6.
9. Sears MR Taylor DR Print CG et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990 336: 1391 6.
10. van Schayck CP Dompeling E van Herwaarden CL et al. Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study. BMJ 1991 303: 1426 31.
11. Cockcroft DW McFarland CP Britto SA Swystun VA Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993 342: 833 7.
12. O'Connor BJ Aikman SL Barnes PJ. Tolerance to the nonbronchodilating effects of inhaled beta 2-agonists in asthma. N Engl J Med 1992 327: 1204 8.
13. Bhagat R Swystun VA Cockcroft DW. Salbutamol-induced increased airway responsiveness to allergen and reduced protection versus methacholine: dose response. J Allergy Clin Immunol 1996 97: 47 52.
14. Slattery D Wong SW Colin AA. Levalbuterol hydrochloride. Pediatr Pulmonol 2002 33: 151 7.
15. Baramki D Koester J Anderson AJ Borish L. Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer. J Allergy Clin Immunol 2002 109: 449 54.
16. Leff AR Herrnreiter A Naclerio RM Baroody FM Handley DA Munoz NM. Effect of enantiomeric forms of albuterol on stimulated secretion of granular protein from human eosinophils. Pulm Pharmacol Ther 1997 10: 97 104.
17. Hansel TT De Vries IJ Iff T et al. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J Immunol Methods 1991 145: 105 10.
18. Busse W Randlev B Sedgwick J. The effect of azelastine on neutrophil and eosinophil generation of superoxide. J Allergy Clin Immunol 1989 83: 400 5.
19. Kita H Abu-Ghazaleh RI Gleich GJ Abraham RT. Regulation of Ig-induced eosinophil degranulation by adenosine 3′,5′-cyclic monophosphate. J Immunol 1991 146: 2712 8.
20. Beavo JA Rogers NL Crofford OB Hardman JG Sutherland EW Newman EV. Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity. Mol Pharmacol 1970 6: 597 603.
21. Gronneberg R Zetterstrom O. Inhibitory effects of formoterol and terbutaline on the development of late phase skin reactions. Clin Exp Allergy 1992 22: 257 63.
22. Kato M Morikawa A Kimura H Shimizu T Nakano M Kuroume T. Effects of antiasthma drugs on superoxide anion generation from human polymorphonuclear leukocytes or hypoxanthine-xanthine oxidase system. Int Arch Allergy Appl Immunol 1991 96: 128 33.
23. Mirza ZN Tokuyama K Arakawa H Kato M Mochizuki H Morikawa A. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy 1998 28: 644 52.
24. Penn RB Frielle T McCullough JR Aberg A Benovic JL. Comparison of R-, S-, and RS-albuterol interaction with human β1- and β2-adrenergic receptors. Clin Rev Allergy Immunol 1996 14: 37 45.
25. Daaka Y Luttrell LM Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997 390: 88 91.
26. Mitra S Ugur M Ugur O Goodman HM McCullough JR Yamaguchi H. (S)-albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle. Mol Pharmacol 1998 53: 347 54.
27. 2+ and guanine nucleotides. J Immunol 1991 147: 1905 11.
28. Adachi T Alam R. The mechanism of IL-5 signal transduction. Am J Physiol 1998 275: C623 33.
29. Nelson HS Bensch G Pleskow WW et al. Improved bronchodilation with levalbuterol compared with racemic albuterol in patients with asthma. J Allergy Clin Immunol 1998 102: 943 52.
30. Truitt T Witko J Halpern M. Levalbuterol compared to racemic albuterol: efficacy and outcomes in patients hospitalized with COPD and asthma. Chest 2003 123: 128 35.
31. Schreck DM Brotea C Shah SP. Comparison of racemic albuterol and levalbuterol in the treatment of acute asthma [abstract]. Ann Emerg Med 2001 38: S10.
32. Schmekel B Rydberg I Norlander B Sjosward KN Ahlner J Andersson RG. Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers. Eur Respir J 1999 13: 1230 5.