The synthesis of bivalent 2β-carbomethoxy-3β-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1832-1841

  Meltzer, Peter C ^a   Kryatova, Olga ^a   Pham Huu, Duy Phong ^a   Donovan, Patrick ^a   Janowsky, Aaron ^b  

^a ORGANIX INC   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Bivalent ligands; Cocaine medications; Monoamine transporter ligands

Indexed keywords

(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)METHYL HEPTANOATE; 2BETA CARBOMETHOXY 3BETA (3,4 DICHLOROPHENYL) 8 HETEROBICYCLO[3.2.1]OCTANE; 3BETA (3,4 DICHLOROPHENYL) 2BETA (3 CARBOXYPROPIONYLOXYMETHYL) 8 OXABICYCLO[3.2.1]OCTANE; 3BETA (3,4 DICHLOROPHENYL) 2BETA (3 CARBOXYPROPIONYLOXYMETHYL) 8 THIABICYCLO[3.2.1]OCTANE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 8 AZATROPANE; 8 BROMOTROPANE; 8 HETEROTROPANE; 8 OXATROPANE; 8 THIATROPANE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2B YL)]METHYL ADIPATE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL DECANEDIOATE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL DODECANEDIOATE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL OCTANEDIOATE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL SUCCINATE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)METHYL (3BETA (3,4 DICHLOROPHENYL) 8 OXABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL SUCCINATE; [(3BETA (3,4 DICHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTAN 2BETA YL)METHYL (3BETA (3,4 DICHLOROPHENYL) 8 THIABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL SUCCINATE; [(3BETA (3,4 DICHLOROPHENYL) 8 OXABICYCLO[3.2.1]OCTAN 2BETA YL)METHYL (3BETA (3,4 DICHLOROPHENYL) 8 THIABICYCLO[3.2.1]OCTAN 2BETA YL)]METHYL SUCCINATE; [(3BETA (3,4 DICHLOROPHENYL) 8 THIABICYCLO[3.2.1]OCTAN 2BETA YL)METHYL (3BETA (3,4 DICHLOROPHENYL) 8 THIABICYCLO[3.2.1]OCTAN-2B-YL)]METHYL SUCCINATE; AMINE; CITALOPRAM; DOPAMINE TRANSPORTER; ETHER; SEROTONIN TRANSPORTER; SULFIDE; TROPANE DERIVATIVE; UNCLASSIFIED DRUG; SEROTONIN UPTAKE INHIBITOR;

ARTICLE; DRUG BINDING SITE; DRUG POTENCY; DRUG SYNTHESIS; IC 50; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; METABOLISM; MOLECULAR PROBE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING SITES; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DRUG DESIGN; HUMANS; MOLECULAR PROBES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 38949169202     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.009     Document Type: Article

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