3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 3, 2000, Pages 581-590

  Meltzer, Peter C ^a   Blundell, Paul ^a   Huang, Hong ^a   Liu, Shanghao ^a   Yong, Yaw F ^a   Madras, Bertha K ^b  

^a ORGANIX INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; BICYCLO[3.2.1]OCTANE DERIVATIVE; CITALOPRAM; COCAINE; DOPAMINE TRANSPORTER; FLUOXETINE; SEROTONIN TRANSPORTER; TRITIUM;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRAIN; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; MONKEY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTANCE ABUSE;

ANIMALS; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CARRIER PROTEINS; CITALOPRAM; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; FEMALE; MACACA FASCICULARIS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

MAMMALIA;

EID: 0034001322     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00322-3     Document Type: Article

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