AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene

Molecular Immunology

Volumn 45, Issue 7, 2008, Pages 2062-2068

  Gopal, Anjali R ^a   Fugmann, Sebastian D ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

DT40; Gene conversion; Immunoglobulin; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN LIGHT CHAIN;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CHICKEN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE CONVERSION; GENE EXPRESSION; GENE LOCUS; IMMUNOGLOBULIN GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ALLELES; ANIMALS; CARRIER PROTEINS; CELL LINE; CHICKENS; CYTIDINE DEAMINASE; DNA MUTATIONAL ANALYSIS; IMMUNOGLOBULIN LIGHT CHAINS; POLYMORPHISM, GENETIC; PRE-B CELL RECEPTORS; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EID: 38949140224     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.10.017     Document Type: Article

References (30)

1. Arakawa H., Hauschild J., and Buerstedde J.M. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295 (2002) 1301-1306
2. Arakawa H., Saribasak H., and Buerstedde J.M. Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol. 2 (2004) E179
3. Betz A.G., Milstein C., Gonzalez-Fernandez A., Pannell R., Larson T., and Neuberger M.S. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 77 (1994) 239-248
4. Buerstedde J.M., Reynaud C.A., Humphries E.H., Olson W., Ewert D.L., and Weill J.C. Light chain gene conversion continues at high rate in an ALV-induced cell line. EMBO J. 9 (1990) 921-927
5. Burgess-Beusse B., Farrell C., Gaszner M., Litt M., Mutskov V., Recillas-Targa F., Simpson M., West A., and Felsenfeld G. The insulation of genes from external enhancers and silencing chromatin. Proc. Natl. Acad. Sci. U.S.A. 99 Suppl. 4 (2002) 16433-16437
6. Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., and Alt F.W. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422 (2003) 726-730
7. Conlon T.M., and Meyer K.B. The chicken Ig light chain 3′-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A. Eur. J. Immunol. 36 (2006) 139-148
8. Fukita Y., Jacobs H., and Rajewsky K. Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity 9 (1998) 105-114
9. Harris R.S., Sale J.E., Petersen-Mahrt S.K., and Neuberger M.S. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr. Biol. 12 (2002) 435-438
10. Longerich S., Basu U., Alt F., and Storb U. AID in somatic hypermutation and class switch recombination. Curr. Opin. Immunol. 18 (2006) 164-174
11. Maizels N. Immunoglobulin gene diversification. Annu. Rev. Genet. 39 (2005) 23-46
12. Martomo S.A., and Gearhart P.J. Somatic hypermutation: subverted DNA repair. Curr. Opin. Immunol. 18 (2006) 243-248
13. Michael N., Shen H.M., Longerich S., Kim N., Longacre A., and Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 19 (2003) 235-242
14. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., and Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
15. Muschen M., Re D., Jungnickel B., Diehl V., Rajewsky K., and Kuppers R. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J. Exp. Med. 192 (2000) 1833-1840
16. Odegard V.H., and Schatz D.G. Targeting of somatic hypermutation. Nat. Rev. Immunol. 6 (2006) 573-583
17. Pasqualucci L., Migliazza A., Fracchiolla N., William C., Neri A., Baldini L., Chaganti R.S., Klein U., Kuppers R., Rajewsky K., and Dalla-Favera R. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11816-11821
18. Pasqualucci L., Neumeister P., Goossens T., Nanjangud G., Chaganti R.S., Kuppers R., and Dalla-Favera R. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412 (2001) 341-346
19. Pham P., Bransteitter R., Petruska J., and Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424 (2003) 103-107
20. Prioleau M.N., Nony P., Simpson M., and Felsenfeld G. An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J. 18 (1999) 4035-4048
21. Rada C., and Milstein C. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J. 20 (2001) 4570-4576
22. Ramiro A.R., Stavropoulos P., Jankovic M., and Nussenzweig M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4 (2003) 452-456
23. Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., Catalan N., Forveille M., Dufourcq-Labelouse R., Gennery A., Tezcan I., Ersoy F., Kayserili H., Ugazio A.G., Brousse N., Muramatsu M., Notarangelo L.D., Kinoshita K., Honjo T., Fischer A., and Durandy A. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102 (2000) 565-575
24. Rosnet O., Blanco-Betancourt C., Grivel K., Richter K., and Schiff C. Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. J. Biol. Chem. 279 (2004) 10228-10236
25. Schoetz U., Cervelli M., Wang Y.D., Fiedler P., and Buerstedde J.M. E2A expression stimulates Ig hypermutation. J. Immunol. 177 (2006) 395-400
26. Seaman M.N. Recycle your receptors with retromer. Trends Cell. Biol. 15 (2005) 68-75
27. Shen H.M., Peters A., Baron B., Zhu X., and Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280 (1998) 1750-1752
28. Sohail A., Klapacz J., Samaranayake M., Ullah A., and Bhagwat A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31 (2003) 2990-2994
29. Tumas-Brundage K., and Manser T. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185 (1997) 239-250
30. Yang S.Y., Fugmann S.D., and Schatz D.G. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J. Exp. Med. 203 (2006) 2919-2928