Prevention of Deoxycholate-Induced Gastric Apoptosis by Aspirin: Roles of NF-κB and PKC Signaling

Journal of Surgical Research

Volumn 145, Issue 1, 2008, Pages 66-73

  Redlak, Maria J ^a   Power, Jacinda J ^a   Miller, Thomas A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bile acid; human gastric cancer epithelial cell line; injury and protection

Indexed keywords

ACETYLSALICYLIC ACID; BILE ACID; DEOXYCHOLIC ACID; GENOMIC DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTACYSTIN; PROTEASOME INHIBITOR; PROTEIN KINASE C;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STOMACH CANCER; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; CASPASES; CELL LINE, TUMOR; CHOLAGOGUES AND CHOLERETICS; COLLAGEN TYPE XI; CYSTEINE PROTEINASE INHIBITORS; DEOXYCHOLIC ACID; HUMANS; NF-KAPPA B; PROTEIN KINASE C; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 38949121954     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.04.039     Document Type: Article

References (42)

1. Dempsey D.T., Mercer D.W., et al. Adaptive cytoprotection of gastric surface epithelial cells against injury by physiologic concentrations of bile acids. Surgery 108 (1990) 348
2. Du Plessis D.J. Pathogenesis of gastric ulceration. Lancet 1 (1965) 974
3. Goldner F.H., and Boyce J.W. Relationship of bile in the stomach to gastritis. Gastrointest Endosc 22 (1976) 197
4. Ritchie W.P. Alkaline reflux gastritis. Ann Surg 203 (1986) 537
5. Kokoska E.R., Smith G.S., Rieckenberg C.L., et al. Adaptive cytoprotection against deoxycholate-induced injury in human gastric cells in vitro. Is there a role for endogenous prostaglandins?. Dig Dis Sci 43 (1998) 806
6. Kokoska E.R., Smith G.S., Wolff A.B., et al. Role of calcium in adaptive cytoprotection and cell injury induced by deoxycholate in human gastric cells. Am J Physiol Gastrointest Liver Physiol 275 (1998) G322
7. Domellof L., Reddy B.S., and Weisburger J.H. Microflora and deconjugation of bile salts in alkaline reflux after partial gastrectomy. Am J Surg 140 (1980) 291
8. Redlak M.J., Dennis M.S., and Miller T.A. Apoptosis is a major mechanism of deoxycholate-induced gastric mucosal cell death. Am J Physiol Gastrointest Liver Physiol 285 (2003) G870
9. Redlak M.J., Power J.J., and Miller T.A. Protein kinase C involvement in deoxycholate-induced apoptosis in human gastric cells. Dig Dis Sci 51 (2006) 834
10. Hawkey C.J. Non-steroidal anti-inflammatory drug gastropathy. Gastroenterology 119 (2000) 521
11. Rich M., and Scheiman J.M. Non-steroidal anti-inflammatory drug gastropathy at the new millennium: Mechanisms and prevention. Semin Arth Rheum 30 (2000) 167
12. Power J.J., Dennis M.S., Redlak M.J., et al. Aspirin-induced mucosal cell death in human gastric cells: Evidence supporting an apoptotic mechanism. Dig Dis Sci 49 (2004) 1518
13. Redlak M.J., Power J.J., and Miller T.A. Aspirin-induced apoptosis in human gastric cancer epithelial cells: Relationship with protein kinase C signaling. Dig Dis Sci 52 (2007) 810
14. Redlak M.J., Power J.J., and Miller T.A. Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol 289 (2005) G731
15. Ali S., and Mann D.A. Signal transduction via the NF-κB pathway: A targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct 22 (2004) 67
16. Caamano J., and Hunter C.A. NF-κB family of transcription factors: Central regulators of innate and adaptive immune functions. Clin Microbiol Rev 15 (2002) 414
17. Schoemaker M.H., Ros J.E., Homan M., et al. Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-κB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis. J Hepatol 36 (2002) 7420
18. Verma I.M. Nuclear factor (NF)-κB proteins: Therapeutic targets. Ann Rheum Dis 63 (2004) ii57
19. Hatano E., Bennet B.L., Manning A.M., et al. NF-κB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-L- and Fas-mediated apoptosis. Gastroenterology 120 (2001) 1251
20. Kawai H., Yamada Y., Tatsuka M., et al. Down-regulation of NF-κB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes. Cancer Res 59 (1999) 6038
21. Lin B., Williams-Skipp C., Tao Y., et al. NF-κB functions as both a pro-apoptotic and anti-apoptotic regulatory factor within a single cell type. Cell Death Differ 6 (1999) 570
22. Boada J., Cuesta E., Roig T., et al. Enhanced antioxidant defenses and resistance to TNF-L in a glycolysis-depleted lung epithelial cell line. Free Radic Biol Med 33 (2002) 1409
23. Daily D., Vlamis-Gardicas A., Offen D., et al. Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by activating NF-κB via Ref-1. J Biol Chem 276 (2001) 1335
24. Lallemand F., Mazars A., Prunier C., et al. Smad7 inhibits the survival nuclear factor kappa B and potentiates apoptosis in epithelial cells. Oncogene 20 (2001) 879
25. Baichwal V.R., and Baeuerle P.A. Activate NF-κB or die?. Curr Biol 7 (1997) R94
26. Yamamoto Y., and Gaynor R.B. Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer. J Clin Invest 107 (2001) 135
27. Grilli M., Pizzi M., Memo M., et al. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κ B activation. Science 274 (1996) 1383
28. Yamamoto Y., Yin M.J., Lin K.M., et al. Sulindac inhibits activation of the NF-κB pathway. J Biol Chem 274 (1999) 27307
29. Yin M.J., Yamamoto Y., and Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396 (1998) 77
30. Bradford H.W. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248
31. Baldwin Jr. A.S. The NF-κB and IκB proteins: New discoveries and insights. Annu Rev Immunol 14 (1996) 649
32. Schmid R.M., and Adler G. NF-κB/Rel/IkB: Implications in gastrointestinal diseases. Gastroenterology 118 (2000) 1208
33. Abraham E. NF-κB activation. Crit Care Med 28 (2000) N100
34. Helmer K.S., Chang L., Cui Y., et al. Induction of NF-κB, IκB-L, and iNOS in rat gastric mucosa during endotoxemia. J Surg Res 104 (2002) 46
35. Pritts T.A., Moon R., Wang Q., et al. Activation of NF-κB varies in different regions of the gastrointestinal tract during endotoxemia. Shock 14 (2000) 118
36. DiDonato J.A., Hayakawa M., Rothwarf D.M., et al. A cytokine-responsive IκB kinase that activates the transcription factor NF-kappaB. Nature 388 (1997) 548
37. Mercurio F., Zhu H., Murray B.W., et al. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 278 (1997) 860
38. Woronicz J.D., Gao X., Cao Z., et al. IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-alpha and NIK. Science 278 (1997) 866
39. Zandi E., Rothwarf D.M., Delhase M., et al. The IκB kinase complex (IKK) contains two kinase subunits, IKK alpha and IKK beta, necessary for IκB phosphorylation and NF-κB activation. Cell 91 (1997) 243
40. Alcaraz M.J., Vicente A.M., Araico A., et al. Role of nuclear factor-κB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells. Br J Pharmacol 142 (2004) 1191
41. Prekeris R., Hernandez R.M., Mayhew M.W., et al. Molecular analysis of the interactions between protein kinase C(ε) and filamentous actin. J Biol Chem 41 (1998) 26790
42. Banan A., Fields J.Z., Farhadi A., et al. The β1 isoform of protein kinase C mediates the protective effects of epidermal growth factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis in human colonic cells. J Pharmacol Exp Ther 301 (2002) 852