Protein kinase C involvement in deoxycholate-induced apoptosis in human gastric cells

Digestive Diseases and Sciences

Volumn 51, Issue 5, 2006, Pages 834-843

  Redlak, Maria J ^a   Power, Jacinda J ^a   Miller, Thomas A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caspases; Cell signaling; Gastric epithelial injury

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BILE ACID; CASPASE 3; CASPASE 6; CASPASE 9; CASPASE INHIBITOR; DEOXYCHOLIC ACID; DNA; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; STOMACH MUCOSA; STOMACH PROTECTION; WESTERN BLOTTING;

APOPTOSIS; CASPASES; CELL LINE; CELLS, CULTURED; DEOXYCHOLIC ACID; EPITHELIAL CELLS; GASTRIC MUCOSA; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN ISOFORMS; PROTEIN KINASE C;

EID: 33745850114     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9346-3     Document Type: Article

References (21)

1. DuPlessis DJ: Pathogenesis of gastric ulceration. Lancet 1:974-978, 1965
2. Ritchie WP: Alkaline reflux gastritis. Ann Surg 203:537-544, 1986
3. Miller TA, Victor BE: Gastritis and gastric ulcer. In Surgical Treatment of Digestive Disease, 2nd ed. Moody FG, Carey LC, Jones RS, Kelly JA, Nahrwold DL, Skinner DB (eds). Chicago, Year Book Medical, 1989, pp. 174-196
4. Kokoska ER, Smith GS, Wolff AB, Deshpande Y, Rieckenberg CL, Banan A, Miller TA: Role of calcium in adaptive cytoprotection and cell injury induced by deoxycholate in human gastric cells. Am J Physiol 275:G322-G330, 1998
5. Kokoska ER, Smith GS, Rieckenberg CL, Deshpande Y, Banan A, Miller TA: Adaptive cytoprotection against deoxycholate-induced injury in human gastric cells in vitro. Dig Dis Sci 4:806-815, 1998
6. Redlak MJ, Dennis MS, Miller TA: Apoptosis is a major mechanism of deoxycholate-induced gastric mucosal cell death. Am J Physiol Gastrointest Liver Physiol 285:G870-G879, 2003
7. Deacon EM, Pongracz J, Griffiths G, Lord JM: Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. J Clin Pathol 50:124-131, 1997
8. Looby E, Long A, Kelleher D, Volkov Y: Bile acid deoxycholate induces differential subcellular localization of the PKC isoenzymes β1, ε and δ in colonic epithelial cells in a sodium butyrate insensitive manner. Int J Cancer 114:887-895, 2005
9. Pongracz J, Clark P, Neoptolemos JP, Lord JM: Expression of protein kinase C isoenzymes in coloreetal cancer tissue and their differential activation by different bile acids. Int J Cancer 61:35-39, 1995
10. Jones BA, Rao YP, Stravitz RT, Gores GJ: Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C. Am J Physiol Gastrointest Liver Physiol 5:G1109-G1115, 1997
11. Facchinetti A, Tessarollo L, Mazzocchi M, Kingston R, Collavo D, Biasi G: An improved method for the detection of DNA fragmentation. J Immunol Meth 136:151-156, 1991
12. Tseng CP, Verma AK: Functional expression and characterization of the mouse epitope tag-protein kinase C isoforms, alpha, beta I, beta II, gamma, delta and epsilon. Gene 169:287-288, 1996
13. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
14. Newton AC: Protein kinase C: structure, function, and regulation. J Biol Chem 48:28495-28498, 1995
15. Darbon JM, Issandou M, Delassus F, Bayard F: Phorbol esters induce both intracellular translocation and down-regulation of protein kinase C inMCF-7 cells. Biochem Biophys Res Commun 137:1159-1166, 1986
16. Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC: A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul 1:693-706, 1990
17. Domellof L, Reddy BS, Weisburger JH: Microflora and deconjugation of bile salts in alkaline reflux after partial gastrectomy. Am J Surg 140:291-295,1980
18. Zhu GH, Wong BC, Slosberg ED, Jiang SH, Kung HF, Soh JW, Weinstein IB: Over-expression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology 118:507-514, 2000
19. Jiang XH, Lam SK, Lin MCM, Eggo MC, Ching CK, Yuen ST, Lai KC, Soh JW, Weinstein IB, Lam SK: Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway. Oncogene 21:6113-6122, 2002
20. Akita Y: Protein kinase C-ε (PKC-ε): its unique structure and function. J Biochem 132:847-852, 2002
21. Prekeris R, Hernandez RM, Mayhew MW, White MK, Terrian DM: Molecular analysis of the interactions between protein kinase C-ε and filamentous actin. J Biol Chem 41:26790-26798, 1998