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54 there is also a legitimate concern that films of citrate-stabilized nanoparticles are inherently unstable and readily aggregate upon placement on a substrate or during assembly into multilayers.
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54 there is also a legitimate concern that films of citrate-stabilized nanoparticles are inherently unstable and readily aggregate upon placement on a substrate or during assembly into multilayers.
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38949207862
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Rotello and coworkers have done excellent work exploring protein interactions with MPCs of this nature in solution36,58 but did not expand their work to a film geometry
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36,58 but did not expand their work to a film geometry.
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59
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These compositions are reported as averages because the polydispersity inherent in MPC samples introduces some degree of variability in core size and, as a consequence, the exact extent of exchange.
-
These compositions are reported as averages because the polydispersity inherent in MPC samples introduces some degree of variability in core size and, as a consequence, the exact extent of exchange.
-
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64
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38949109929
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SAMs composed of shorter chain-length thiolates tend to be inherently disordered regardless of deposition time, whereas films created from longer chain thiols require longer periods of time to become structurally ordered and stable.65
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65
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66
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79
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38949184167
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Films of this nature have freely diffusing and uncoordinated metal ion linkers throughout their structure.66,67 If metal cations are able to migrate to the interface, it is likely that they would disrupt the electrostatic immobilization of the protein, thereby causing lower protein coverage and serving as a significant factor in the poorly defined protein voltammetry Figure 3
-
66,67 If metal cations are able to migrate to the interface, it is likely that they would disrupt the electrostatic immobilization of the protein, thereby causing lower protein coverage and serving as a significant factor in the poorly defined protein voltammetry (Figure 3).
-
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80
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0037133902
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Hicks, J. F.; Young, S.; Murray, R. W. Langmuir 2002, 18, 2288-2294.
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81
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38949169508
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60 and are consistent with the TEM analysis of our materials (Supporting Information).
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60 and are consistent with the TEM analysis of our materials (Supporting Information).
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82
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38949206505
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Exchange reaction parameters (reaction time and MUA concentration) were carefully manipulated to create MPCs with similar average MUA content as verified by the NMR analysis of iodine decomposed samples. However, chain-length effects on the propensity of MUA in solution to exchange/displace surface thiolates cannot be completely dismissed since the C12/MUA system consistently showed low MUA content regardless of the exchange reaction parameters.
-
Exchange reaction parameters (reaction time and MUA concentration) were carefully manipulated to create MPCs with similar average MUA content as verified by the NMR analysis of iodine decomposed samples. However, chain-length effects on the propensity of MUA in solution to exchange/displace surface thiolates cannot be completely dismissed since the C12/MUA system consistently showed low MUA content regardless of the exchange reaction parameters.
-
-
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83
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38949213980
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One possible explanation for this occurrence may be that, with the MUA ligands significantly longer than the hexanethiolates in a mixed peripheral layer, there may be some bending of the chains that exposes the hydrophobic methylene units and subsequently accelerates denaturation of the protein
-
One possible explanation for this occurrence may be that, with the MUA ligands significantly longer than the hexanethiolates in a mixed peripheral layer, there may be some bending of the chains that exposes the hydrophobic methylene units and subsequently accelerates denaturation of the protein.
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84
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38949120838
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Statistical hypothesis testing of the difference in mean samples was performed as a one tail, standardized Student's t test, assuming nonhomogeneous variance and a conservative estimate of the degrees of freedom.
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Statistical hypothesis testing of the difference in mean samples was performed as a one tail, standardized Student's t test, assuming nonhomogeneous variance and a conservative estimate of the degrees of freedom.
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85
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