RRR-α-tocopherol regulation of gene transcription in response to the cell oxidant status

Zeitschrift fur Ernahrungswissenschaft

Volumn 37, Issue SUPPL. 1, 1998, Pages 21-28

  Azzi, A ^a   Boscoboinik, D ^a   Fazzio, A ^a   Marilley, D ^a   Maroni, P ^a   Ozer N K ^a   Spycher, S ^a   Tasinato, A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antioxidants; AP 1 transcription factor; Arteriosclerosis; Protein kinase C; RRR tocopherol; Smooth muscle cell proliferation

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; PROTEIN KINASE C; TRANSCRIPTION FACTOR AP 1;

ANTIOXIDANT ACTIVITY; ARTERIOSCLEROSIS; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; OXIDATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIOXIDANTS; AORTA; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA; GENE EXPRESSION REGULATION; MUSCLE, SMOOTH, VASCULAR; PROTEIN KINASE C; RATS; RECOMBINANT PROTEINS; STEREOISOMERISM; TETRADECANOYLPHORBOL ACETATE; THYMIDINE; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION; VITAMIN E;

EID: 0031925048     PISSN: 0044264X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. Alexander DR, Graves JD. Lucas SC, Cantrcll DA, Crumpton MJ (1990) A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation. Biochem J 268:303-8
2. Azzi A, Boscoboinik D, Châtelain E, Özer NK, Stauble B (1993) d-alphatocopherol control of cell proliferation. Mol Aspects Med 14:265-71
3. Azzi A, Boscoboinik D, Marilley D, Özer NK, Stauble B, Tasinato A (1995) Vitamin E, a sensor and an information transducer of the cell oxidation state. Am J Clin Nutr. in press
4. Boscoboinik D, Szewczyk A, Azzi A (1991) Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Arch Biochem Biophys 286:264-9
5. Boscoboinik D, Szewczyk A, Hensey C, Azzi A (1991) Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. J Biol Chem 266:6188-94
6. Boscoboinik DO, Châtelain E, Bartoli GM, Stauble B, Azzi A (1994) Inhibition of protein kinase C activity and vascular smooth muscle cell growth by d-alphatocopherol. Biochim Biophys Acta 1224:418-26
7. Carew TE, Schwenke DC, Steinberg D (1987) Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sei USA. 84:7725-9
8. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polyrnerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-89
9. Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E (1993) Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 57:787S-97S
10. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Wille WC (1993) Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328:1450-6
11. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s (1993) Nature 362:801-9
12. Ross R, Glomset JA (1973) Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science 180:1332-9
13. Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis. N Engl J Med 295:369-77
14. Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis N Engl J Med 295:420-5
15. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC (1993) Vitamin E consumption and the risk of coronary disease in women N Engl J Med 328:1444 9.
16. Stauble B, Boscoboinik D, Tasinato A, Azzi A (1994) Modulation of activator protein-1 (AP-I) transcription factor and protein kinase C by hydrogen peroxide and D-x-tocopherol in vascular smooth muscle cells. Eur J Biochem 226:393-402
17. Tasinato A, Boscoboinik D, Barioli GM, Azzi A (1995) d-a-Tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition and is independent of its antioxidant properties. Proc Natl Acad Sei USA. 92: 12190-12194